Projects and Investigators

FY 2002 Projects

University of Alabama

Objective

Preclinical development of 9-cis-UAB30, a nuclear retinoid X receptor selective agonist for breast cancer.

Program Description

Investigators will conduct preclinical development of 9-cis-UAB30, a nuclear retinoid X selective agonist receptor, for breast cancer chemoprevention. Retinoids that selectively interact with nuclear retinoid X receptors (RXRs) have been shown to be effective in the prevention of mammary cancer either alone or in combination with antiestrogens. 9-cis-UAB30 represents a new class of RXR-selective retinoids and has been shown to be nontoxic and effective in a cancer chemopreventive mammary model. RAPID support will include:

• bulk synthesis and preclinical toxicology studies.

Contact Information

Dr. Donald D. Muccio
University of Alabama
Birmingham, AL
Tel: 205-934-4747
Fax: 205-934-2543
E-mail: muccio@uab.edu