Projects and Investigators
FY 2002 Projects
University of Arizona
Objective
Preclinical development of a topical niacin prodrug for skin cancer prevention.
Program Description
Investigators will conduct preclinical development of a topical niacin prodrug for skin cancer prevention. It has been proposed that a topical application of niacin prodrug will prevent, reverse early signs of skin cancers (actinic keratoses), or inhibit progression to cancer. This agent may exert its effects by stimulation of poly(ADP-ribose) polymerase (PARP-1) activity and leptin and their downstream signaling pathways. RAPID support will include:
- Preclinical toxicology studies,
- Analytical method development,
- Absorption/distribution/metabolism/elimination studies, and
- Animal efficacy studies.
Contact Information
Dr. Elaine L. Jacobson
University of Arizona
College of Pharmacy and Arizona Cancer Center
Tucson, AZ
Tel: 520-626-2272
Fax: 520-626-8567
E-mail: elaine.jacobson@pharmacy.arizona.edu