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Rapid Access to Preventive Intervention Development (RAPID) Program

Projects and Investigators

FY 2002 Projects

University of Arizona

Objective

Preclinical development of a topical niacin prodrug for skin cancer prevention.

Program Description

Investigators will conduct preclinical development of a topical niacin prodrug for skin cancer prevention. It has been proposed that a topical application of niacin prodrug will prevent, reverse early signs of skin cancers (actinic keratoses), or inhibit progression to cancer. This agent may exert its effects by stimulation of poly(ADP-ribose) polymerase (PARP-1) activity and leptin and their downstream signaling pathways. RAPID support will include:

  • Preclinical toxicology studies,
  • Analytical method development,
  • Absorption/distribution/metabolism/elimination studies, and
  • Animal efficacy studies.

Contact Information

Dr. Elaine L. Jacobson
University of Arizona
College of Pharmacy and Arizona Cancer Center
Tucson, AZ
Tel: 520-626-2272
Fax: 520-626-8567
E-mail: elaine.jacobson@pharmacy.arizona.edu