Projects and Investigators

FY 2000 Projects

Roswell Park Cancer Institute

Objective

Evaluation of Se-methylselenocysteine for cancer prevention.

Program Description

Investigators will evaluate Se-Methylselenocysteine, a selenium containing amino acid. The substance is a good precursor of methylselenol and this monomethylated selenium is an important factor in chemoprevention. Se-Methylselenocysteine is found in many plant species, e.g. garlic, broccoli, and onions. It has been shown to inhibit the growth of chemically induced tumors in animal models at dietary concentrations as low as 2 ppm selenium. RAPID support will include:

• Mutagenicity and short-term preclinical toxicity testing,
• GMP synthesis, formulation, and packaging, and IND support.

Contact Information

Clement Ip
Roswell Park Cancer Institute
New York, NY
Tel: 716-845-8875
Fax: 716-845-8100
E-mail: Clement.Ip@RoswellPark.org