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Definition(s)

The tendency in certain genetic disorders for individuals in successive generations to present at an earlier age and/or with more severe manifestations; often observed in disorders resulting from the expression of a trinucleotide repeat mutation that tends to increase in size and have a more significant effect when passed from one generation to the next

Click here for More information from GeneTestsThis link leads to a site outside Genetics Home Reference.

Definition from: GeneTestsThis link leads to a site outside Genetics Home Reference. from the University of Washington and Children's Health System, Seattle

Each generation of offspring has increased severity of a genetic disorder; e.g., a grandchild may have earlier onset and more severe symptoms than the parent, who had earlier onset than the grandparent.

Definition from: Human Genome Project InformationThis link leads to a site outside Genetics Home Reference. at the U.S. Department of Energy

Related discussion in the Handbook

 
Published: January 23, 2009