New Technique Removes Toxic Protein and Prevents Memory Impairment in Alzheimer's Disease ModelWednesday, Dec 5, 2007
Increasing the activity of a key protein in the bloodstream slows the buildup of a toxic substance in the brains of mice with
the gene mutation for Alzheimer's disease (AD). It also prevents some memory problems, a new study shows. If the approach
works in humans, it may eventually lead to a way of preventing or halting AD.
Evaluation of Patients Treated With Natalizumab Finds No New Cases of Progressive Multifocal LeukoencephalopathyWednesday, Mar 1, 2006
An independent clinical and laboratory study of more than 3000 people treated with the drug natalizumab (Tysabri®) for multiple
sclerosis (MS), Crohn’s disease, and rheumatoid arthritis has found no evidence of new cases of the often-fatal disorder called
progressive multifocal leukoencephalopathy (PML). The laboratory component of the study was coordinated by the National Institute
of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH), working in conjunction with the NIH
Clinical Center.
Study Links Restless Legs Syndrome to Poor Iron Uptake in the BrainMonday, Aug 11, 2003
Results of the first-ever autopsy study of brains from people with restless legs syndrome (RLS) suggest that the disorder
may result from inefficient processing of iron in certain brain cells. The findings provide a possible explanation for this
disorder and may lead to new ways of treating the disease.
Fact Sheet Pressure Combined with Heat Reduces Prion Infectivity in Processed MeatsMonday, May 5, 2003
The combination of high temperature and very high pressure in the preparation of processed meats such as hot dogs and salami
may effectively reduce the presence of infective prions while retaining the taste, texture, and look of these meats, according
to a new study.
Fact Sheet NIH Scientists Identify Gene for Fatal Childhood Disorder, Niemann-Pick Type C: Finding Points to Critical New Steps in Cholesterol
ProcessingThursday, Jul 10, 1997
Bethesda, MD -- After decades of work, scientists at the National Institutes of Health have identified a gene alteration associated
with the fatal childhood cholesterol disorder Niemann-Pick type C (NPC). Learning how the gene functions may lead to the
first effective treatment for the disease and to a fundamental new understanding of how cholesterol is processed in the body.