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UGID:159239     UniGene Hs.181368     Homo sapiens (human)   PRPF8 Order cDNA clone, Links
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) (PRPF8)
SELECTED PROTEIN SIMILARITIES
Comparison of sequences in UniGene with selected protein reference sequences. The alignments can suggest function of a gene.
Reference ProteinSpeciesId(%)Len(aa)
NP_619600.2 pre-mRNA processing factor 8 M. musculus 100.0 2334
XP_001080695.1 PREDICTED: similar to Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8) (PRP8 homolog) (220 kDa U5 snRNP-specific protein) (p220) R. norvegicus 100.0 2334
XP_001365062.1 PREDICTED: similar to splicing factor Prp8 M. domestica 100.0 2334
NP_006436.3 U5 snRNP-specific protein H. sapiens 100.0 2334
XP_854384.1 PREDICTED: similar to Pre-mRNA processing splicing factor 8 (Splicing factor Prp8) (PRP8 homolog) (220 kDa U5 snRNP-specific protein) (p220) isoform 2 C. lupus familiaris 100.0 2334
XP_001504382.1 PREDICTED: similar to Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8) (PRP8 homolog) (220 kDa U5 snRNP-specific protein) (p220) E. caballus 100.0 2334
NP_001099108.1 PRP8 pre-mRNA processing factor 8 homolog B. taurus 100.0 2334
XP_001117328.1 PREDICTED: U5 snRNP-specific protein M. mulatta 100.0 2290
XP_523763.2 PREDICTED: U5 snRNP-specific protein, partial P. troglodytes 100.0 886
XP_001515844.1 PREDICTED: similar to PRP8 pre-mRNA processing factor 8 homolog (yeast), partial O. anatinus 100.0 1934
XP_415805.2 PREDICTED: similar to splicing factor Prp8 G. gallus 99.9 2334
NP_001080253.1 pre-mRNA processing factor 8 X. laevis 99.7 2334
NP_957270.2 pre-mRNA processing factor 8 D. rerio 99.4 2341
NP_610735.1 prp8 CG8877-PA D. melanogaster 96.2 2330
NP_498785.1 yeast PRP (splicing factor) related family member (prp-8) C. elegans 92.2 2324
NP_178124.1 SUS2 (ABNORMAL SUSPENSOR 2) A. thaliana 90.4 2368
XP_001689471.1 splicing factor, component of the U5 snRNP and of the spliceosome C. reinhardtii 88.9 2337
XP_328538.1 hypothetical protein N. crassa 81.8 2361
NP_012035.1 Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing; mutations of human Prp8 cause retinitis pigmentosa; Prp8p S. cerevisiae 71.9 2341

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Expression Profile: View expression levels using UniGene's EST ProfileViewer
[Show more entries with profiles like this]
Note: Highly represented in several libraries
GEO profiles: Gene expression profiles in the NCBI Gene Expression Omnibus database
cDNA Sources: brain; mammary gland; eye; embryonic tissue; uncharacterized tissue; intestine; placenta; skin; prostate; lung; pancreas; uterus; kidney; testis; mouth; stomach; lymph node; liver; ovary; bone; blood; cervix; larynx; mixed; adrenal gland; ganglia; trachea; spleen; pharynx; lymph; connective tissue; muscle; umbilical cord; thyroid; pituitary gland; amniotic fluid; nerve; epididymis; thymus; heart; bone marrow; esophagus; vascular; tonsil; peritoneum; bladder; salivary gland; adipose tissue
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 17
Map position: 17p13.3
UniSTS entry: Chr 17 STS-W58284
UniSTS entry: Chr Y D10S2448
UniSTS entry: Chr 17 SHGC-148294
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (13)

AF092565.1 Homo sapiens splicing factor Prp8 mRNA, complete cds PA
BX649099.1 Homo sapiens mRNA; cDNA DKFZp686L08123 (from clone DKFZp686L08123) PA
NM_006445.3 Homo sapiens PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) (PRPF8), mRNA PA
BC064370.1 Homo sapiens PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae), mRNA (cDNA clone MGC:74762 IMAGE:5587081), complete cds PA
AY486135.1 Homo sapiens apoptosis-regulated protein 1 mRNA, partial cds P
AY486134.1 Homo sapiens apoptosis-regulated protein 2 mRNA, partial cds P
CR624543.1 full-length cDNA clone CS0DK002YE23 of HeLa cells Cot 25-normalized of Homo sapiens (human) P
CR605208.1 full-length cDNA clone CS0DI086YI24 of Placenta Cot 25-normalized of Homo sapiens (human) P
AK222905.1 Homo sapiens mRNA for U5 snRNP-specific protein variant, clone: HRC03173 PA
AK058034.1 Homo sapiens cDNA FLJ25305 fis, clone SYN00254, highly similar to Homo sapiens mRNA for PRP8 protein P
AK296344.1 Homo sapiens cDNA FLJ57882 complete cds, highly similar to Pre-mRNA-processing-splicing factor 8 PA
BC034545.1 Homo sapiens PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:4473590), with apparent retained intron PA
AB007510.1 Homo sapiens mRNA for PRP8 protein, complete cds P

EST sequences (10 of 1247) [Show all sequences]

AI003867.1 Clone IMAGE:1619796 testis 3' read P
AI015319.1 Clone IMAGE:1618762 testis 3' read PA
AI033604.1 Clone IMAGE:1656213 mixed 3' read P
AI215822.1 Clone IMAGE:1884316 lung 3' read PA
AI250277.1 Clone IMAGE:2000262 lymph node 3' read PA
AI250623.1 Clone IMAGE:2004361 pancreas 3' read A
AI083646.1 Clone IMAGE:1751190 brain 3' read P
CB145323.1 Clone L16HLK3-19-F12 liver 5' read P
CB161518.1 Clone L17N670205n1-34-F07 liver 5' read P
CB162332.1 Clone L17N670205n1-42-D11 liver 5' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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