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Inversion

Definition(s)

A chromosomal rearrangement in which a segment of genetic material is broken away from the chromosome, inverted from end to end, and re-inserted into the chromosome at the same breakage site. Balanced inversions (no net loss or gain of genetic material) are usually not associated with phenotypic abnormalities, although in some cases gene disruptions at the breakpoints can cause adverse phenotypic effects, including some known genetic diseases; unbalanced inversions (loss or gain of chromosome material) nearly always yield an abnormal phenotype.: Definition from: GeneTests from the University of Washington and Children's Health System, Seattle
Chromosome segments that have been turned 180 degrees. The gene sequence for the segment is reversed with respect to the rest of the chromosome.: Definition from: Human Genome Project Information at the U.S. Department of Energy


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