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Marker chromosome

Synonym(s)

  • supernumary chromosome

Definition(s)

A small chromosome containing a centromere occasionally seen in tissue culture, often in a mosaic state (present in some cells but not in others). A marker chromosome may be of little clinical significance or, if it contains material from one or both arms of another chromosome, may create an imbalance for whatever genes are present; assessment to establish clinical significance, particularly if found in a fetal karyotype, is often difficult.

Definition from: GeneTestsThis link leads to a site outside Genetics Home Reference. from the University of Washington and Children's Health System, Seattle

 
Published: January 23, 2009