Michigan State University
Pediatrics and Human Developmental
246 Food Safety and Toxicology Building
East Lansing, MI 48824-1302
Phone: 517-884-2053
Fax: 517-432-6340
Email:
Satoh, Andrea Y., James E. Trosko, and Susan Masten. 2007. Methylene blue dye test for rapid qualitative detection of hydroxyl radicals formed in a Fenton's reaction aqueous solution. Environmental Science and Technology. (http://pubs.acs.org/journals/esthag/) 41(8):2881-7.
Tai, Mei-Hui, Brad L. Upham, L. Karl Olson, Ming-Sound Tsao, Donald N. Reed, and James E. Trosko. 2007. Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells. International Journal of Cancer. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=29331) 120(9):1855-62.
Upham, Brad L., Miodrag Guzvic, Jacob Scott, Joseph M. Carbone, Ludek Blaha, Chad Coe, Lan lan Li, Alisa M. Rummel, and James E. Trosko. 2007. Inhibition of gap junctional intercellular communication and activation of mitogen-activated protein kinase by tumor-promoting organic peroxides and protection by resveratrol. Nutrition and Cancer. (http://www.periodicals.com/html/ihp_e.html?en 15013) 57(1):38-47.
2005
Loch-Caruso, Rita, Brad L. Upham, Craig Harris, and James E. Trosko. 2005. Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 85(1):694-702.
Luster-Teasley, Stephanie L., Patricia E. Ganey, Mary DiOrio, Joseph S. Ward, Robert E. Maleczka, James E. Trosko, and Susan Masten. 2005. Effect of byproducts from the ozonation of pyrene: Biphenyl-2,2 ',6,6 '-tetracarbaldehyde and biphenyl-2,2 ',6,6 '-tetracarboxylic acid on gap junction intercellular communication and neutrophil function. Environmental Toxicology and Chemistry. (http://etc.allenpress.com/entconline/?request =index-html) 24(3):733-740.
Trosko, James E. and Brad L. Upham. 2005. The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment. Mutagenesis. 20(2):81-92.
2004
Davila, Julio C., Gabriela G. Cezar, Mark Thiede, Stephen Strom, Toshio Miki, and James E. Trosko. 2004. Use and application of stem cells in toxicology. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 79(2):214-223.
Linning, Katrina D., Mei-Hui Tai, Burra V. Madhukar, Chia-Cheng Chang, Donald N. Reed, Sarah Ferber, James E. Trosko, and L. Karl Olson. 2004. Redox-mediated enrichment of self-renewing adult human pancreatic cells that possess endocrine differentiation potential. Pancreas. (http://www.pancreasjournal.com/pt/re/pancreas /home.htm;jsessionid=CDoa08NQBzxHARf1ksCris2A 8FoSdbidq5JQI8mpbtR8RDT9m8PQ!583875742!-94985 6031!9001!-1) 29(3):E64-E76.
Moggs, Jonathan G., Jay I. Goodman, James E. Trosko, and Ruth A. Roberts. 2004. Epigenetics and cancer: implications for drug discovery and safety assessment. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) 196(3):422-430.
Nakamura, Yasushi, James E. Trosko, Chia-Cheng Chang, and Brad L. Upham. 2004. Psyllium extracts decreased neoplastic phenotypes induced by the Ha-Ras oncogene transfected into a rat liver oval cell line. Cancer Letters. (http://www.sciencedirect.com/science/journal/ 03043835) 203(1):13-24.
Ogawa, Takahiko, Tomonori Hayashi, Seishi Kyoizumi, Yoichiro Kusunoki, Kei Nakachi, Donald G. MacPhee, James E. Trosko, Katsuko Kataoka, and Noriaki Yorioka. 2004. Anisomycin downregulates gap-junctional intercellular communication via the p38 MAP-kinase pathway. Journal of Cell Science. (http://jcs.biologists.org/contents-by-date.0. shtml) 117(10):2087-2096.
Park, Joon-Suk, Dong-Young Noh, Seok-Hyun Kim, Sung-Hoon Kim, Gu Kong, Chia-Cheng Chang, Yong-Soon Lee, James E. Trosko, and Kyung-Sun Kang. 2004. Gene expression analysis in SV40-immortalized human breast luminal epithelial cells with stem cell characteristics using a cDNA microarray. International Journal of Oncology. (http://www.spandidos-publications.com/ijo/) 24(6):1545-1558.
Trosko, James E., Chia-Cheng Chang, Brad L. Upham, and Mei-Hui Tai. 2004. Ignored hallmarks of carcinogenesis: Stem cells and cell-cell communication. Annals of the New York Academy of Science. (http://www.nyas.org/) 1028:192-201.
2003
Hilscherova, Klara, Alan L. Blankenship, Kurunthachalam Kannan, M. Nie, Lisa L. Williams, Katherine K. Coady, Brad L. Upham, James E. Trosko, Steven J. Bursian, and John P. Giesy. 2003. Oxidative stress in laboratory-incubated double-crested cormorant eggs collected from the Great Lakes. Archives of Environmental Contamination and Toxicology. (http://link.springer.de/link/service/journals /00244/tocs.html) 45(4):533-546.
Hilscherova, Klara, Alan L. Blankenship, M. Nie, Katherine K. Coady, Brad L. Upham, James E. Trosko, and John P. Giesy. 2003. Oxidative stress in liver and brain of the hatchling chicken (Gallus domesticus) following in ovo injection with TCDD. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. (http://www.sciencedirect.com/science/journal/ 15320456) 136(1):29-45.
Holland, Margo S., Lorrie D. Griffin, James E. Trosko, and Robert E. Holland. 2003. Ontogeny of bovine mammary gland progenitor cells. In: Proceedings of the Tuskegee University Medical Symposium, March 3-6.
Luster-Teasley, Stephanie L., J.J. Yao, H.H. Herner, James E. Trosko, and Susan Masten. 2003. Ozonation of Chrysene: Evaluation of By-product Mixtures and Identification of Toxic Constituents. Environmental Science and Technology. (http://pubs.acs.org/journals/esthag/) 36(5):869-876.
Machala, Miroslav, Ludek Blaha, Jan Vondracek, James E. Trosko, Jacob Scott, and Brad L. Upham. 2003. Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: Inhibitory potencies and screening for potential mode(s) of action. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 76(1):102-111.
Satoh, Andrea Y., James E. Trosko, and Susan Masten. 2003. Epigenetic toxicity of hydroxylated biphenyls and hydroxylated polychlorinated biphenyls on normal rat liver epithelial cells. Environmental Science and Technology. (http://pubs.acs.org/journals/esthag/) 37(12):2727-2733.
Tai, Mei-Hui, L. Karl Olson, Burra V. Madhukar, Katrina D. Linning, Loretta L. Van Camp, Ming-Sound Tsao, and James E. Trosko. 2003. Characterization of Gap Junctional Intercellular Communication in Immortalized Human Pancreatic Ductal Epithelial Cells With Stem Cell Characteristics. Pancreas. (http://www.pancreasjournal.com/pt/re/pancreas /home.htm;jsessionid=CDoa08NQBzxHARf1ksCris2A 8FoSdbidq5JQI8mpbtR8RDT9m8PQ!583875742!-94985 6031!9001!-1) 26(1):e18-e26.
Tai, Mei-Hui, Donald N. Reed, Chia-Cheng Chang, and James E. Trosko. 2003. Role of pancreatic stem cells in the emergence of pancreatic stellate cells and fibroblast-like cells in chronic pancreatitis. In: Proceedings of Pediatrics and Human Development Research Day Symposium. Michigan State University, East Lansing, MI.
Trosko, James E. 2003. Epigenetic toxicant-induced modulation of Cell-cell comunication/pesticides/risk assessment: Different mechanisms but all roads lead to Rome. In: Proceedings of the International Symposium of the American Chemical Society, March 24. New Orleans,, LA.
Trosko, James E. 2003. Human stem cells as targets for the aging and diseases of aging processes. Medical Hypotheses. (http://www.sciencedirect.com/science/journal/ 03069877) 60(3):439-447.
Trosko, James E. 2003. Isolating adult human stem cells and their use in treating various human diseases by their use in screening for potential Chemopreventive agents. In: Proceedings of the First Nagasaki Symposium of International Consortium for Medical Care of Hibasusha and Radiation Life Sciences. Feb. 21-22. Nagasaki, Japan.
Trosko, James E. 2003. Scientific Concepts of Human Nature and their Implications to Bioethics in a scientific and Technologically-Altered World. Journal of International Society of Bioethics. 68-83.
Trosko, James E. 2003. The role of stem cells and gap junctional intercellular communication in carcinogenesis. Journal of Biochemical and Molecular Toxicology. (http://www.interscience.wiley.com/jpages/1095 -6670/) 36(1):43-48.
Trosko, James E. and Chia-Cheng Chang. 2003. Hallmarks of Radiation Carcinogenesis: Ignored Concepts. In: Radiation and Humankind. Elsevier Science, Amsterdam, Netherlands. pp.31-36.
Trosko, James E. and Chia-Cheng Chang. 2003. Isolation and characterization of normal adult human epithelial pluripotent stem cells. Oncology Research. (http://www.cognizantcommunication.com/filecab inet/Oncology/onc.htm) 13(6-10):353-357.
Trosko, James E., Chia-Cheng Chang, Mei-Hui Tai, and Brad L. Upham. 2003. The role of stem cells and cell-cell communication in cancer chemoprevention stategies. In: Proceedings of the ICMAA-VII (8th International Conference on mechanisms of anti-mutagenesis and anticarcinogenesis) Oct. 4-8. Pisa, Italy.
Upham, Brad L., Tyler R. Koski, Alisa M. Rummel, Melinda R. Wilson, Anelia Horvath, and James E. Trosko. 2003. Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis. Cancer Letters. (http://www.sciencedirect.com/science/journal/ 03043835) 191(1):27-34.
Upham, Brad L., Alisa M. Rummel, Joseph M. Carbone, James E. Trosko, Yanli Ouyang, Robert B. Crawford, and Norbert Kaminski. 2003. A Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line. International Journal of Cancer. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=29331) 104(1):12-18.
Upham, Brad L., Junji Suzuki, Gang Chen, Yurong Wang, Laura R. McCabe, Chia-Cheng Chang, Vladimir A. Krutovskikh, Hiroshi Yamasaki, and James E. Trosko. 2003. Reduced gap junctional intercellular communication and altered biological effects in mouse osteoblast and rat liver oval cell lines transfected with dominant-negative connexin 43. Molecular Carcinogenesis. (http://www.interscience.wiley.com/jpages/0899 -1987/) 37(4):192-201.
2002
Horvath, Anelia, Brad L. Upham, Varban Ganev, and James E. Trosko. 2002. Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line. Toxicon. 40:273-282.
Hu, Wenyue, Paul D. Jones, Brad L. Upham, James E. Trosko, Christopher Lau, and John P. Giesy. 2002. Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 68(2):429-436.
Luster-Teasley, Stephanie L., J.J. Yao, H.H. Herner, James E. Trosko, and Susan Masten. 2002. Ozonation of Chrysene: Evaluation of By-product Mixtures and Identification of Toxic Constituents. Environmental Science and Technology. (http://pubs.acs.org/journals/esthag/) 36(5):869-876.
Trosko, James E. 2002. Up-regulation of cell-cell communication in the prevention/chemotherapy of cancer cells. In: Chemicals in the 21st Century: Chemicals for a sustainable Development, (H.R.H. Prrincess Chulabhorn, ed.,) Trinity Publishing Co., , Thailand. Trinity Publishing Co, Bangkok, Thailand. pp.180-186.
Trosko, James E. and Chia-Cheng Chang. 2002. Epigenetic --toxicant induced modulated gap junctional intercellular communication. In: Comprehensive Toxicology: Cellular and Molecular Toxicology. Elserier Publishing, Amsterdam, Netherlands. pp.409-420.
Trosko, James E., Chia-Cheng Chang, and Brad L. Upham. 2002. Modulation of gap junctional communication by 'epigenetic toxicants': A shared mechanism in teratogenesis, carcinogenesis, atherogenesis, immunomodulation, reproductive- and neuro-toxicities. In: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives(http://www.amazon.com/exec/obidos/tg/detail/- /1566705967/qid=1125592445/sr=1-1/ref=sr_1_1/ 102-5267823-2464935?v=glance&s=books) . CRC Press Company, Boca Raton, FL. pp.445-454.
Upham, Brad L., Jim M. Davis, James E. Trosko, and Kenneth A. Schwartz. 2002. Polycyclic aromatic hydrocarbons with bay-like structures inhibited gap junctional intercellular communication in neonatal rat cardiomyocytes and caused asynchronous beating. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 00:1410.
2001
Herner, Holly A., James E. Trosko, and Susan Masten. 2001. The Epigenetic Toxicity of Pyrene and Related Ozonation Byproducts Containing an Aldehyde Functional Group. Environmental Science and Technology. (http://pubs.acs.org/journals/esthag/) 35(17):3576-3583.
Masten, Susan, Ming Tian, Brad L. Upham, and James E. Trosko. 2001. Effect of selected pesticides and their ozonation by-products on gap junctional intercellular communication using rat liver epithelial cell lines. Chemosphere. (http://www.sciencedirect.com/science/journal/ 00456535) 44(3):457-465.
Ruch, Randall J., James E. Trosko, and Burra V. Madhukar. 2001. Inhibition of connexion43 gap junctional intercellular communication by TPA requires ERK activation. Journal of Cellular Biochemistry. (http://www.interscience.wiley.com/jpages/0730 -2312/) 83(1):163-169.
Tian, Ming, Susan Masten, Brad L. Upham, and James E. Trosko. 2001. Effect of selected pesticides and their ozonation by-products on gap junctional intercellular communication using rat liver epithelial cell lines. Chemosphere. (http://www.sciencedirect.com/science/journal/ 00456535) 44(3):457-465.
Trosko, James E. 2001. Commentary: is the concept of "tumor promotion" a useful paradigm?. Molecular Carcinogenesis. (http://www.interscience.wiley.com/jpages/0899 -1987/) 30(3):131-137.
Trosko, James E. 2001. Dietary modulation of gap junctonal communication during the rate limiting step of the initiation/promotion/progression process of carcinogenesis. Mutation Research. (http://www.elsevier.com/wps/find/journaldescr iption.cws_home/522820/description#descriptio n) 483:S7.
Trosko, James E. 2001. Gap junctional intercellular communication: A 'Biological Rosetta Stone' concept for understanding 'Epigenetic' toxicology. In: Proceedings of the Asian Society of Toxicology.
Trosko, James E. 2001. Modulation of gap junctional communication by 'epigenetic' toxicants: A shared mechanism in teratogenesis, atherogenesis, carcinogenesis, reproductive-, immuno- and neuro-toxicities. In: Arctic Development, Pollution and Biomarkers of Human Health. Elsevier Science Publishers, Amsterdam, Netherlands.
Trosko, James E. 2001. Up-regulation of cell-cell communication in the chemoprevention/chemotherapy of cancer cells. In: Proceedings of the Fourth Princess Chulabhorn International Science Congress, Chemicals in the 21st Century.
Trosko, James E., K. Kwan, Brad L. Upham, R. Halgren, Timothy R. Zacharewski, and Chia-Cheng Chang. 2001. Stem cell biology in toxicology. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 60:150.
Upham, Brad L., Alisa M. Rummel, Joseph M. Carbone, James E. Trosko, Yanli Ouyang, and Norbert Kaminski. 2001. Cannabinoids inhibited gap junctional intercellular communication and activated extracellular receptor kinase in a rat liver epithelial cell line. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 60:750.
Upham, Brad L., James E. Trosko, I. Hirose, Ryuichi Hasegawa, J. Kanno, Tohru Inoue, and Kimie Sai. 2001. Structure-activity relationships of perfluorinated fatty acids on gap junctional intercellular communication and MAPK using in vivo and in vitro model systems. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 60:746.
2000
Sai, Kimie, J. Kanno, Ryuichi Hasegawa, James E. Trosko, and Tohru Inoue. 2000. Prevention of the down-regulation of gap junctional intercellular communication by green tea in the liver of mice fed pentachlorophenol. Carcinogenesis. (http://carcin.oupjournals.org/) 21:1671-1676.
Trosko, James E., Chia-Cheng Chang, Melinda R. Wilson, Brad L. Upham, Tomonori Hayashi, and M. Wade. 2000. Gap junctions and the regulation of cellular functions of stem cells during development and differentiation. Methods. (http://www.elsevier.com/wps/find/journaldescr iption.cws_home/622914/description#descriptio n) 20(2):245-264.
1999
Ghoshal, S., Walter J. Weber, Alisa M. Rummel, James E. Trosko, and Brad L. Upham. 1999. Epigenetic toxicity of a mixture of polycyclic aromatic hydrocarbons on gap junctional intercellular communication before and after biodegradation. Environmental Science and Technology. (http://pubs.acs.org/journals/esthag/) 33:1044-1050.
Rummel, Alisa M., James E. Trosko, Melinda R. Wilson, and Brad L. Upham. 1999. Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 49:232-240.
1998
Trosko, James E. and Randall J. Ruch. 1998. Cell-cell communication in carcinogenesis. Frontiers in Bioscience. (http://www.bioscience.org/) 3:d208-d236.
Trosko, James E., Chia-Cheng Chang, Brad L. Upham, and Melinda R. Wilson. 1998. Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication. Toxicology Letters. (http://www.sciencedirect.com/science/journal/ 03784274) 102-103:71-78.
Upham, Brad L., N.D. DeoCampo, B. Wurl, and James E. Trosko. 1998. Inhibition of gap junctional intercellular communication by perfluorinated fatty acids dependent on the chain length of the fluorinated tail. International Journal of Cancer. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=29331) 78:491-495.
Upham, Brad L., L.M. Weis, and James E. Trosko. 1998. Modulated gap junctional intercellular communication as a biomarker of PAH epigenetic toxicity: structure-function relationship. Environmental Health Perspectives. 106:975-984.
Weis, L.M., Alisa M. Rummel, Susan Masten, James E. Trosko, and Brad L. Upham. 1998. Bay or bay-like regions of polycyclic aromatic hydrocarbons were potent inhibitors of gap junction intercellular communication. Environmental Health Perspectives. 106(1):17-22.
1997
Madhukar, Burra V. and James E. Trosko. 1997. The causes of cancer: Implications for prevention and treatment. Indian Journal of Pediatrics. 64:131-141.
Upham, Brad L., B. Boddy, X. Xing, James E. Trosko, and Susan Masten. 1997. Non-genotoxic effects of selected pesticides and their disinfection by-products on gap junctional intercellular communication. Ozone Science and Engineering. (http://www.crcpress.com/us/product.asp?dept_i d=1&sku=CRJ30&mscssid=) 19(4):351-369.
Upham, Brad L., K.S. Kang, H-Y Cho, and James E. Trosko. 1997. Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not in glutathione deficient cells. Carcinogenesis. (http://carcin.oupjournals.org/) 18:37-42.
1996
Hayashi, Tomonori, C.M. Hasler, S.Y. Oh, Burra V. Madhukar, Chia-Cheng Chang, and James E. Trosko. 1996. Characterization of an in vitro human kidney epithelial system to study gap junctional intercellular communication. In Vitro & Molecular Toxicology. (http://www.liebertonline.com/ivt?cookieSet=1) 9:3-17.
Kang, K.S., Melinda R. Wilson, Tomonori Hayashi, Chia-Cheng Chang, and James E. Trosko. 1996. Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs and PBBs, alone or in mixtures. Environmental Health Perspectives. 104:192-200.
Madhukar, Burra V., H. de Feijter-Rupp, and James E. Trosko. 1996. Pulse treatment with tumor promoter TPA delays the onset of desensitization response and prolongs the inhibitory effect on gap junctional intercellular communication of a rat liver epithelial cell line WB F-344. Cancer Letters. (http://www.sciencedirect.com/science/journal/ 03043835) 106:117-123.
Nomata, K., K.S. Kang, Tomonori Hayashi, Donald K. Milton, L. Lockwood, Chia-Cheng Chang, and James E. Trosko. 1996. Inhibition of gap junctional intercellular communication in heptachlor- and heptachlor epoxide-treated normal human breast epithelial cells. Cell Biology and Toxicology. 12:69-78.
Trosko, James E. 1996. Role of low-level ionizing radiation in multi-step carcinogenic process. Health Physics. (http://www.health-physics.com/) 70(6):812-822.
Trosko, James E., Chia-Cheng Chang, Burra V. Madhukar, and E. Dupont. 1996. Intercellular communication: A paradigm for the interpretation of the initiation/promotion/ progression model of carcinogenesis. In: Chemical Induction of Cancer: Modulation and Combination Effects. Birkhauser Publisher, Boston, MA. pp.3.17-3.29.
Upham, Brad L., B. Boddy, X. Xing, James E. Trosko, and Susan Masten. 1996. Non-genotoxic effects of selected pesticides and their disinfection by-products on gap junctional intercellular communication. In: Proceedings of the IOA (International Ozone Association) Pan American Conference: Applications and Optimization of Ozone for Potable Water Treatment, Sept. 8-11. Ottawa, Ontario, Canada.
Upham, Brad L., L.M. Weis, Alisa M. Rummel, Susan Masten, and James E. Trosko. 1996. The Effects of Anthracene and Methylated Anthracenes on Gap Junctional Intercellular Communication in Rat Liver Epithelial Cells. Fundamental and Applied Toxicology. (http://www.sciencedirect.com/science/journal/ 02720590) 34(2):260-264.
1995
Upham, Brad L., J.J. Yao, James E. Trosko, and Susan Masten. 1995. Determination of the efficacy of ozone treatment systems using a gap junction intercellular communication bioassay. Environmental Science and Technology. (http://pubs.acs.org/journals/esthag/) 29:2923-2928.
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