Direct Publications
The sample of indirect publications from the MLPCN and MLSCN centers for each of the following years can be found here.
Direct Manuscripts (From MLSCN Funded Grants) 2008 (64 total) Characterization of chemical libraries for luciferase inhibitory activity. Auld, D.S., Southall, N., Jadhav, A., Johnson R.L., Diller D., Simeonov A., Austin, C.P, & Inglese, J. Journal of Medicinal Chemistry, 2008, 10.1021/jm701302v Specific Mechanism for Nonspecific Activation in Reporter-Gene Assays. Auld, D.S., Thorne, N., Nguyen, D.T. & Inglese, J.A. Chemical Biology, 2008, 3(8), 463-470. Bagaoglu, K., Simeonov, A., Irwin, J., Nelson, M., Feng, B.Y., Thomas, C., Cancian, L., Costi, MP., Maltby, D., Jadhav, A., Inglese, A., Austin, C.P., & Shoichet. B.K. Journal of Medicinal Chemistry, 2008, in press. Bakan, A, Lazo, J., Wipf, P., Brummond K., & Bahar, I. Current Med. Chem., 2008, in press. Molecular docking of cathepsin L inhibitors in the binding site of papain. Beavers, M., Myers, M., Shaw, P., Diamond, S., & Smith, A. J. Chem. Information & Modeling, 2008, 48(7), 1464-1472. COPI complex is a regulator of lipid homeostasis. Beller, M., Sztalryd, C., Southall, N., Bell, M., Jackle, H., Auld, D.S. & Oliver, B. PLoS Biol, 2008, 6(11): e292. doi:10.1371/journal.pbio.0060292 A comparative analysis of standard microtiter plate reading versus imaging in cellular assays. Bushway, P., Mercola, M. & Price, J. Assay and Drug Development Technologies, 2008, 6(4), 557-567. deAlmeida, R.A., Burgess, D., Shema, R., Motlekar, N., Napper, A.D., Diamond, S.L. & Pavitt., G.D. Yeast, 2008, 25, 71-76. Dennis, M., Bowles, H., MacKenzie, D., Burchiel, S., Edwards, B., Sklar, L., Prossnitz, E., & Thompson, T. Cytometry, 2008, 7, 390-9 Dai, S., Chalmers, M., Bruning, J., Bramlett, K., Osborne, H., Montrose-Rafizadeh, C., Barr, R., Wang, Y., Wang, M., Burris, T., Dodge, J., & Griffin, P. Proc. Natl. Acad. Sci. USA, 2008, 105, 7171-7176. Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2007. Dolle, R.E., Bourdonnec, B., Goodman, A., Morales, G., Thomas, C. & Zhang W. Journal of Combinatorial Chemistry, 2008, 10(6), 753-802. A fluorescent plate reader assay for ceramide kinase. Don, A.S., & Rosen, H. Analytical Biochemistry, 2008, 375(2), 265-271. Gonzalez-Cabrera, P.J., Jo, E., Sanna, M.G., Brown, S., Leaf, N., Marsolais, D., Schaeffer, M.T., Chapman, J., Cameron, M., Guerrero, M., Roberts, E. & Rosen, H. Mol Pharmacol, 2008, 74(5), 1308-1318. Guha, R., & Schurer, S. Comp. Aided. Mol. Des., 2008, 22, 367-384. Hsieh, J-H., Wang, X.S., Teotico, D., Golbraikh, A. & Tropsha, A. J. Comput Aided Mol Des, 2008, DOI 10.1007/s10822-008-9199-2 Huang, R., Southall, N., Cho, M.H., Xia, M., Inglese, J., & Austin, C.P. Chem. Res. Toxicol., 2008, 21(3), 659–667. Ivnitski-Steele, I., Lawson, R.S., Lovato, D.M., Khawaja, H.M., Winter, S.S., Oprea, T.I., Sklar L.A., & Edwards, B.S. Assay and Drug Development Technologies, 2008, 6(2), 263-276. Jiang, J.K., Ghoreschi, K., Deflorian, F., Chen, Z., Perreira, M., Pesu, M., Smith, J., Nguyen, D.T., Liu, E.H., Leister, W., Costanzi, S., O'Shea, J.J., Thomas, C.J. Journal of Medicinal Chemistry, 2008, In press. A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Johnson, R., Huang, W., Jadhav, A., Austin, C.P., Inglese, J., & Martinez, E.D. Analytical Biochemistry, 2008, 375, 237-248. Tetracycline-Inducible Gene Expression in Conditionally Immortalized Mouse Podocytes. Kajiyama, H., Titus, S., Austin, C., Chiotos, K., Matsumoto, T., Sakairi, T. & Kopp, J. American Journal of Nephrology, 2008, 29, 153-163. Kim, I., Shu, C., Xu, W., Shiau, C.W., Grant, D., Vasile, S., Cosford, N., Reed, J. J. Biol Chem., 2008, In press. Lauer-Fields, J.L., Minond, D., Chase, P., Baillargeon, P., Saldanha, S., Stawikowska, R., Hodder, P., & Fields, G. Bioorg. & Med. Chem. Letters, 2008, In press. Lauer-Fields, J.L., Spicer, T.P., Chase, P.S., Cudic, M., Burstein, G.D., Nagase, H., Hodder, P. & Fields, GB. Analytical Biochemistry, 2008, 373, 43-51.
Is Cdc25 a druggable target? Lazo, J., & Wipf P. Anti-cancer Agents Med Chem., 2008, In press. Lea, W.A., Jadhav, A., Rai, G., Sayed, A., Cass, C., Inglese, J., Williams, D., Austin, C,P. & Simeonov, A. Assay and Drug Development Technologies, 2008, 6, 551-555. Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists. Lewis, M., Sheffler, D., Williams, R., Bridges, T., Kennedy, J.P., Brogan, J.T., Mulder, M.J., Williams, L., Nalywajko, N.T., Niswender, C., Weaver, C., Conn, P.J., Lindsley, C.W. Bioorg. & Med. Chem. Lett, 2008, 885-890. Potent, selective and cell penetrant inhibitors of SF-1 by functional uHTS. Madoux, F., Li, X., Chase, P., Zastrow, G., Cameron, M.D., Conkright, J.J., Griffin, P.R., Thacher, S. & Hodder, P. Molecular Pharmacology, 2008, 73(6), 1776-1784. Marchand, C., Lea, W., Jadhav, A., Dexheimer, T., Austin, C.P., Inglese, J., Pommier, Y. & Simeonov, A. Molecular Cancer Therapeutics, 2008, In press. Marinello, J., Marchand, C., Mott, B.T., Bain, A., Thomas, C.J., Pommier, Y. Biochemistry, 2008, 27(36), 9345-9354. Marsolais, D., Hahm,B., Edelmann, K.H., Walsh, K.B., Guerrero, M., Hatta, Y., Kawaoka, Y., Roberts, E., Oldstone, M.B. & Rosen, H. Mol Pharmacol., 2008, 74(3), 896-903. A robotics platform for quantitative high-throughput screening. Michael, S., Auld, D., Klumpp, C., Jadhav, A., Zheng, W., Thorne, N., Austin, C.P., Inglese, J. & Simeonov A. Assay and Drug Development Technologies, 2008, 6(5), 637-657. Evaluation of an orthogonal pooling strategy for rapid high throughput screening of proteases. Moltekar, N., Diamond, S.L., & Napper, A. Assay & Drug Dev. Tech., 2008, 6(3), 395-405. Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Myers, M.C., Shah, P.P., Diamond, S.L., Huryn, D.M., & Smith, A.B. Bioorganic and Medicinal Chemistry Letters, 2008, 18, 210-214. Nakai, R., Salisbury, C.M., Rosen, H., & Cravatt, B.F. Bioorganic & Medicinal Chemistry, 2008, doi: 10.1016/j.bmc.2008.03.018 Neumann, S., Kleinau, G., Costanzi, S., Moore, S., Jiang, J.K., Raaka , B.M., Thomas, C.J., Krause, G., & Gershengorn, M.C. Endocrinology, 2008, 149(12), 5945-5950. Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Niessen, F., Schaffner, F., Furlan-Freguia, C., Pawlinski, R., Bhattacharjee, G., Chun, J., Derian, C. K., Andrade-Gordon, P., Rosen, H., Ruf, W. Nature, 2008, 452, 654-658. Niswender, C.M., Johnson, K.A., Luo, Q., Ayala, J., Kim, C., Conn, P.J., & Weaver, D. Molec. Pharmacology, 2008, In press. Estrogen Signaling through the Transmembrane G protein-coupled Receptor GPR30. Prossnitz, E., Arterburn, J., Smith, H., Oprea, T., Sklar, L. & Hathaway H. Ann. Rev. Physiol., 2008, 70, 165-190. GPR30: a novel therapeutic target in estrogen-related disease Prossnitz, E., Arterburn, J., Oprea, T., & Sklar, L. TIPS, 2008, 29, 116-123. Modulating tone: the overture of S1P receptor immunotherapeutics. Rosen, H., Gonzalez-Cabrera, P., Marsolais, D., Cahalan, S., Don, A. S., Sanna, M. G. Immunol. Rev., 2008, 223, 221-235. Roth, J., Madoux, F., Hodder, P. & Roush, W. Bioorg. Med Chem Lett., 2008, 18(8), 2628-2632. Advances in Multiple Analyte Profiling. Salas, V., Edwards, B., & Sklar, L. Adv Clin Chem, 2008, 45, 47-74 Identification of oxadiazoles as new drug leads for control of schistosomiasis. Sayed, A.A., Simeonov, A., Thomas, C.J., Inglese, J., Austin, C.P., & Williams, D.L. Nature Medicine, 2008, 14, 407-412. Schröter, T., Minond, D., Weiser, A., Dao, C., Habel, J., Spicer, T., Chase, P., Baillargeon, P., Scampavia, L., Schürer, S., Chung, C., Mader, C., Southern, M., Tsinoremas, N., LoGrasso, P., & Hodder, P. J. Biomolecular Screening, 2008, In press. Schürer, S., Brown, S., Gonzales Cabrera, P., Schaeffer, M-T., Chapman, J., Jo, E., Chase, P., Spicer, T., Hodder, P. & Rosen, H. ACS Chem Biol,, 2008, 3(8), 486-498.
Shah, P., Myers, M., Beavers, M., Pruvis, J., Huryn, D., Smith, A., & Diamond, S. Molec. Pharmacol., 2008, In press. Potent and selective disruption of protein kinase d functionality by a benzoxoloazepinolone. Sharlow, E.R., Giridhar, K., Lavelle, C., Chen, J., Leimgruber, S., Barrett, R., Bravo-Altamirano, K., Wipf, P., Lazo, J., & Wang, Q. J. Biol Chem., 283(48), 33516-33526. Sharlow, E., Leimgruber, S., Yellow-Duke, A., Barrett, R., Wang, Q., & Lazo, J.S. Nature Protocols, 2008, In Press. An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Shirey, J.K., Xiang, Z., Orten, D., Brady, A.E., Johnson, K.A., Williams, R., Ayala, J.E., Rodriquez, A.L., Wess, J., Weaver, D., Niswender, C., & Conn, J.P. Nature Chemical Biology, 2008, 4, 42-50. Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. Simeonov, A., Jadhav, A., Sayed, A.A., Wang, Y., Nelson, M.E., Thomas, C.J., Inglese, J., Williams, D.L., & Austin, C.P. PLoS Negl Trop Dis, 2008, 2, e127. Simeonov, A., Yasgar, A., Jadhav, A., Lokesh, G.L., Klumpp, C., Michael, S., Austin, C.P., Natarajan, A., & Inglese, J. Analytical Biochemistry, 2008, 375, 60-70. Fluorescence Spectroscopic Profiling of Compound Libraries. Simeonov, A., Jadhav, A., Thomas, C.J., Wang, Y., Huang, R., Southall, N., Shinn, P., Smith, J., Austin, C.P., & Inglese, J. Journal of Medicinal Chemisty, 2008, in press. Identification of a potent new chemotype for the selective inhibition of PDE4. Skoumbourdis, A.P., Huang, R., Southall, N., Leister, W., Guo, V., Cho, M.H., Inglese, J., Nirenberg, M., Austin, C.P., Xia, M., & Thomas, C.J. Bioorganic and Medicinal Chemistry Letters, 2008, 18 (4),1297-1303. Titus, S., Neumann, S., Zheng, W., Southall, N., Michael, S., Klumpp, C., Yasgar, A., Shinn, P., Thomas, C.J., Inglese, J., Gershengorn, M.C., & Austin, C.P. Journal of Biomolecular Screening, 2008, 13(2), 120-127. A Cell-Based PDE4 Assay in 1536-Well Plate Format for High-Throughput Screening. Titus, S., Xiao, L., Southall, N., Lu, J., Inglese, J., Brasch, M., Austin , C. P. & Zheng, W. Journal of Biomolecular Screening, 2008, In press. Urban, D.J., Zheng, W., Goker-Alpan, O., Jadhav, A., LaMarca, M.E., Inglese, J., Sidransky, E. & Austin, C.P. Combinatorial Chemistry & High Throughput Screening, 2008, In press. Vogt, A., McDonald, P.R., Tamewitz, A., Sikorski, R., Wipf, P., Skoko, J.J., & Lazo, J.S. Molecular Cancer Therapeutics, 2008, In press. Identification of Off-Patent Drugs That Reverse Daunorubicin Efflux Mediated by ABCB1 in T-ALL Cells. Winter, S,. Lovato, D., Khawaja, H., Edwards, B., Ivnitski-Steele. I., Young, S., Estes, D., Oprea, T., Sklar, L., & Larson, R. SBS, 2008, 15, 185-193. Compound cytotoxicity profiling using quantitative high-throughput screening. Xia, M., Huang, R., Witt, K.L., Southall, N., Fostel, J., Cho, M.H., Jadhav, A., Smith, C.S., Inglese, J., Portier, C.J., Tice, R.R., & Austin, C.P. Environmental Health Prospectives, 2008, In press. Data mining a small molecule drug screening representative subset from NIH PubChem. Xie, X.-Q. & Chen, J.-Z. Journal of Chemical Information and Modeling, 48(3), 465-475. Xie, Y., Deng, S., Thomas, C.J., Liu, Y., Zhang, Y-Q., Rinderspacher, A., Huang, W., Gong, G., Wyler, M., Cayanis, E., Aulner, N., Tobben, U., Chung, C., Pampou, S., Southall, N., Vidovic, D., Schurer, S., Branden, L., Davis, R. E., Staudt, L. M., Inglese, J., Austin, C.P., Landry, D.W., Smith, D.H., & Auld, D.S. Bioorganic and Medicinal Chemistry Letters, 2008, 18, 329-335. Compound management for quantitative high-throughput screening. Yasgar, A., Shinn, P., Jadhav, A., Auld, D.S., Michael, S., Zheng, W., Austin, C.P., Inglese, J., & Simeonov, A. Journal of the Association for Laboratory Automation, 2008, 12(2), 79-89. Zhu, H., Rusyn, I., Richard, A. & A. Tropsha Environmental Health Perspectives, 2008, 116, 4, 506-513. Zhu, P.J., Zheng, W., Auld, D.S., Jadhav, A., Macarthur, R., Olson , K.R., Peng, K., Dotimas, H., Austin, C.P., Inglese, J. Combinatorial Chemistry & High Throughput Screening, 2008, 11(7), 545-559.
bold indicates screening center PI 2007 1. Albanito, L., Madeo, A., Lappano, R., Vivacqua, A., Rago, V., Carpino, A., Oprea, T., Prossnitz, E., Musti, A., Ando, S., & Maggiolini, M. (2007). G Protein-Coupled Receptor 30 (GPR30) Mediates Gene Expression Changes and Growth Response to 17b -Estradiol and Selective GPR30 Ligand G-1 in Ovarian Cancer Cells. Cancer Res, 67:1859-1866. 2. Ariazi, E.A., Leitao, A., Oprea, T.I., Chen, B., Louis, T., Betucci, A.M., Sharma, C.G.N., Gill, S.D., Kim, H.R., Shupp, H.A., Pyle, J.R., Madrack, A., Donato A.L., Cheng, D., Paige, J.R., & Jordan, V.C. (2007). Exemestane’s 17-hydroxylated metabolite exerts biological effects as an androgen. Molecular Cancer Therapeutics, 11, 2817-2827. 3. Arnold, D. M., Foster, C., Huryn, D. M., Lazo, J. S., Johnston, P.A., &n Wipf, P. (2007). Synthesis and Biological Activity of a Focused Library of Mitogen-activated Protein Kinase Phosphatase Inhibitors. Chemical Biology & Drug Design, 69, 23-30. 4. Auld, D.S., Inglese, J., Jadhav, A., Austin, C.P., Sittampalam, G.S., Montrose-Rafizadeh, C., Mcgee, J.E., & Iversen, P.W. (2007). HTS technologies to facilitate chemical genomics. European Pharma. Review, 2: 53-63. 5. Buranda, T., Waller, A., Wu, Y., Simons, P.C., Biggs, S., Prossnitz, E.R., & Sklar, L.A. (2007). Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads. Advanced Protein Chemistry, 74, 95-135. 6. Davis, R.E., Zhang, Y., Southall, N., Staudt, L.M., Austin, C.P., Inglese, J., & Auld, D.S. (2007). A Cell-Based Assay for IKBa Stabilization Using Two-Color Dual Luciferase-Based Sensor. Assay and Drug Development Technologies, 5: 85-103. 7. Diamond, S.L. (2007). Methods for mapping protease specificity. Current Opinion in Chemical Biology, 11, 46-51. 8. Don, A.S., Martinez-Lamenca, C., Webb, W.R., Proia, R.L., Roberts, E., & Rosen, H. (2007). Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY710 analogues. Biological Chemistry, 282, 15833-15842. 9. Du, Y., Moulick, K., Rodina, A., Aguirre, J., Felts, S., Dingledine, R., Fu, H. & Chiosis, G. (2007). High-throughput screening fluorescence polarization assay for tumor-specific Hsp90. Journal of Biomolecular Screening, 12, 915-924. 10. Edwards, B., Ivnitski-Steele, I., Young, S., Salas, V.,.Sklar, L. (2007). High Throughput Cytotoxicity Screening by Propidium Iodide Staining. Current Protocols in Cytometry, In press 11. Edwards, B., Young, S., Saunders, M., Bologa. C,, Oprea. T,, Ye, R., Prossnitz, E., Graves, S., & Sklar, L. (2007). High Throughput Flow Cytometry for Drug Discovery. Expert Opin Drug Discov 2, 685-696. 12. Edwards, B., Young, S., Ivnitski-Steele, I., Ye, R., Prossnitz, E., & Sklar, L. High content screening: flow cytometry analysis. In:P. A. Clemons, N. J. Tolliday, and B. K. Wagner (eds.), Cell Based Assays in High-Throughput Screening. Totowa, NJ: Humana Press, Inc., in press, 2007. 13. Feng, B.Y, Simeonov, A., Jadhav, A., Babaoglu, K., Inglese, J., Shoichet, B.K., & Austin, C.P. (2007). A High-throughput Screen for Aggregation-based inhibition in a Large Compound Library. J. Med. Chem, 50: 2385-2390. 14. Ganesh, T. (2007). Improved biochemical strategies for targeted delivery of taxoids, Bioorg Med Chem, 15, 3597-3623. 15. Gonzalez-Cabrera, P.J., Hla, T., & Rosen., H. (2007). Mapping Pathways Downstream of Sphingosine 1-Phosphate Subtype 1 by Differential Chemical Perturbation and Proteomics. Journal of Biological Chemistry, 282, 7254-7264. 16. Honson, N. S., Johnson, R. L., Huang, W., Inglese, J., Austin, C.P., & Kuret, J. (2007). Differentiating Alzheimer disease-associated aggregates with small molecules. Neurobiology of Disease, 28(3), 251-260. 17. Hristozov, D. P., Oprea, T.I., & Gasteiger, J. (2007). Ligand-based virtual screening by novelty detection with self-organizing maps. J. Chem. Inf. Model., 47, 2044-2062. 18. Huang, W., Zheng, W., Urban, D.J., Inglese, J., Sidransky, E., Austin, C.P., & Thomas, C.J. (2007). N4-Phenyl modifications of N2-(2-hydroxyl)ethyl-6(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease. Bioorganic and Medicinal Chemistry Letters, 17, 5783-5789. 19. Huryn, D. M., & Cosford, N. D. P. (2007). Chapter 26 the molecular libraries screening center network (MLSCN): Identifying chemical probes of biological systems. Annual Reports in Medicinal Chemistry 42, 401-416 20. Inglese, J., Johnson, R.L., Simeonov, A., Xia, M., Austin, C.P., & Auld, D.S. (2007). High-throughput screening assays for the identification of chemical probes. Nature Chemical Biology, 3: 466-479. 21. Inglese, J., Shamu, C.E., & Guy, R.K. (2007). Reporting data from high-throughput screening of small-molecule libraries. Nature Chemical Biology, 3: 438-441. 22. Johnston, P.A., Foster, C.A., Shun, T.Y., Skoko, J.J., Shinde, S., Wipf, P., & Lazo, J.S. (2007). Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors. Assay and Drug Development Technologies, 5: 319-332. 23. Johnston, P.A., Phillips, J., Shun, T.Y., Shinde, S., Lazo, J.S., Huryn, D. M., Myers, M. C., Ratnikov, B.I., Smith, J.W., Su, Y., Dahl, R., Cosford, N., Shiryaev, S.A., & Strongin, A.Y. (2007). HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus. Assay and Drug Development Technologies, 5, 737-750. 24. Lazo, J. S., Brady, L., & Dingledine, R. (2007). Building a pharmacological lexicon: small molecule discovery in academia. Molecular Pharmacoogy, 72 , 1-17. 25. Lazo, J.S., Skoko, J.J., Werner, S., Mitasev, B., Bakan, A., Koizumi, F., Yellow-Duke, A., Bahar, I., & Brummond, K.M. (2007).Structurally unique inhibitors of human mitogen-activated protein kinase phosphatase-1 identified in a pyrrole carboamide library. Journal of Pharmacology and Experimental Therapeutics, 322, 940-947. 26. Lee, H-K., Brown, S.J., Rosen, H., & Tobias, P.S. (2007). Application of B-lactamase enzyme complementation to the high-throughput screening of toll-like receptor signaling inhibitors. Molecular Pharmacology, 72, 868-875. 27. Myers, M. C., Napper, A.D., Motlekar, N., Shah, P.P., Chiu, C.H., Beavers, M.P., Diamond, S.L., Huryn, D.M., & Smith, III., A.B. (2007). Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: The confounding effects of DTT and cysteine in biological assays. Bioorg Med Chem Lett, 17, 4761-4766. 28. Naivar, M.A., Parson, J.D., Wilder, M.E., Habbersett, R.C., Edwards, B.S., Sklar, L., Nolan, J.P., Graves, S.W., Martin, J.C., Jett, J.H., & Freyer, J.P. (2007). Open, reconfigurable cytometic acquisition system: ORCAS. Cytometry Part A, 71, 915-924. 29. Oprea, T. I., Allu, T.K, Fara, D.C., Rad, R.F., Ostopovici, L., & Bologa, C.G. (2007).Lead-like, drug-like or "Pub-like": how different are they? J Comput Aided Mol Des, 21. 30. Oprea, T. I., Tropsha, A., Faulon, J.L., Rintou, M.D. (2007). Systems chemical biology. Nat Chem Biol, 3, 447-450. 31. Prossnitz, E. R., Arterburn, J.B., & Sklar, L.A. (2007). GPR30: A G protein-coupled receptor for estrogen. Mol Cell Endocrinol, 265-266. 32. Revankar, C.M., Mitchell, H.D., Field, A.S., Burai, R., Corona, C., Ramesh, C., Sklar, L.A., Arterburn, J.B., & Prossnitz, E.R. (2007). Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. ACS Chemical Biology, 2: 536-544. 33. Rosen, H., Sanna, M.G., Calahan, S.M., & Gonzalez-Cabrera, P.J. (2007). Tipping the gatekeeper: S1P regulation of endothelial barrier function. Trends in Immunology, 28, 102-107. 34. Sharlow, E.R., Leimgruber, S., Shung, T.Y., & Lazo, J.S. (2007). Development and implementation of a miniaturized high-throughput time-resolved fluorescence energy transfer assay to identify small molecule inhibitors of polo-like kinase 1. Assay and Drug Development Technologies, 5, 723-735. 35. Simeonov, A., Yasgar, A., Klumpp, C., Zheng, W., Shafqat, N., Oppermann, U., Austin, C.P., & Inglese, J. (2007). Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification. Assay and Drug Development Technologies, 5, 815-824. 36. Simons, P.C., Young, S.M., Gibaja, V., Lee, W-C., Josiah, S., Edwards, B.S., & Sklar, L.A. (2007). Duplexed, bead-based competitive assay for inhibitors of protein kinases. Cytometry Part A, 71, 451-459. 37. Sklar. L.A., Carter, M.B., Edwards, B.S. (2007). Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening. Current Opinion in Pharmacology, 7, 527-534. 38. Skoumbourdis, A.P., Moore, S., Landsman, M., & Thomas, C.J. (2007). Synthesis of substituted 2-phenylhistamines via a microwave promoted Suzuki coupling. Tetrahedron Letters, 48, 9140-9143. 39. Sun, A., Chandrakumar, N., Yoon, J-J., Plemper, R.K., & Snyder, J.P. (2007). Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation. Bioorganic and Medicinal Chemistry Letters, 17, 5199-5203. 40. Thepchatri, P., Eliseo, T., Cicero, D.O., Myles, D., & Snyder, J.P. (2007). Relationship among ligand conformations in solution, in the solid state, and at the Hsp90 binding site: geldanamycin and radicicol. J Am Chem Soc, 129, 3127-3134. 41. Tran, T.C., Sneed, B., Haider, J., Blavo, D., White, A., Aiyejorun, T., Baranowski, T.C., Rubinstein, A.L., Doan, T.N., Dingledine, R., & Sandberg, E.M. (2007). Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Cancer Research, 67, 11386-11392. 42. Vogt, A., & Lazo, J.S. (2007). Implementation of high-content assay for inhibitors of mitogen-activated protein kinase phosphatases, Methods, 42, 268-277. 43. Wu, Y., Buranda, T., Simons, P.C., Lopez, G.P., McIntire, W.E., Garrison, J.C., Prossnitz, E.R., & Sklar, L.A. (2007). Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides. Analytical Biochemistry, 371: 10-20. 44. Wu, Y., Campos, S.K., Lopez, G.P., Ozbun, M.A., Sklar, L.A., & Buranda, T. (2007). The development of quantum dot calibration beads and quantitative multicolor bioassays in flow cytometry and microscopy. Anal Biochem, 364, 180-192. 45. Wu, Y., Lopez, G.P., Sklar, L.A., & Buranda, T. (2007). Spectroscopic characterization of streptavidin functionalized quantum dots. Anal Biochem, 364, 194-203. 46. Zheng, W., Padla, K., Urban, D.J., Jadhav, A., Goker-Alpan, O., Simeonov, A., Goldin, E., Auld, D., LeMarca, M.E., Inglese, J., Austin, C.P., & Sidransky, E. (2007). Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proceedings of the National Academy of Sciences of the United States of America, 104: 13192-13197. Edited by CR: 06/16/08
