Identifies chromosomal aberrations |
|
Translocations (balanced) |
Yes |
Translocations (unbalanced) |
Yes |
Copy number changes |
Yes |
Additions (>10MB) |
Yes |
Deletions (>10MB) |
Yes |
Deletions of specific genes/loci |
No |
Inversions |
Sometimes |
Insertions |
Yes |
Identifies presence of markers |
Yes |
Distinguishes between double minutes and homogeneously staining regions |
Yes |
Identifies chromosomal origins |
Yes |
Identifies specific p/q arms/bands |
No |
Requires specifically labeled probes |
Yes |
More than two probes at one time |
Yes |
Requires viable material |
Yes |
Requires metaphase spreads |
Yes |
Applicable to interphase nuclei |
No |
Applicable to DNA extracted from paraffin embedded tissue |
No |
Affected by normal tissue contamination |
Yes |
Identifies tumor heterogeneity |
Yes |
Applicable for studies in other species |
Yes |