Stage I Renal Cell Cancer
Current Clinical Trials
Stage I renal cell cancer is defined by the following clinical stage grouping:
Surgical resection is the accepted, often curative, therapy for stage I renal
cell cancer. Resection may be simple or radical. The latter operation
includes removal of the kidney, adrenal gland, perirenal fat, and Gerota
fascia, with or without a regional lymph node dissection. Some, but not all,
surgeons believe the radical operation yields superior results. In patients
who are not candidates for surgery, external-beam radiation therapy (EBRT) or arterial
embolization can provide palliation. In patients with bilateral stage I
neoplasms (concurrent or subsequent), bilateral partial nephrectomy or
unilateral partial nephrectomy with contralateral radical nephrectomy, when
technically feasible, may be a preferred alternative to bilateral nephrectomy
with dialysis or transplantation.[1] Increasing evidence suggests that a
partial nephrectomy is curative in selected cases. A
pathologist should examine the gross specimen as well as the frozen section from the
parenchymal margin of excision.[2]
Standard treatment options:
- Radical nephrectomy.[3]
- Simple nephrectomy.[3]
- Partial nephrectomy (selected patients).[1,3]
- EBRT (palliative).[3]
- Arterial embolization (palliative).[3,4]
- Clinical trials.
Current Clinical Trials
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage I renal cell cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
References
-
Novick AC, Streem S, Montie JE, et al.: Conservative surgery for renal cell carcinoma: a single-center experience with 100 patients. J Urol 141 (4): 835-9, 1989.
[PUBMED Abstract]
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Thrasher JB, Robertson JE, Paulson DF: Expanding indications for conservative renal surgery in renal cell carcinoma. Urology 43 (2): 160-8, 1994.
[PUBMED Abstract]
-
deKernion JB, Berry D: The diagnosis and treatment of renal cell carcinoma. Cancer 45 (7 Suppl): 1947-56, 1980.
[PUBMED Abstract]
-
Swanson DA, Wallace S, Johnson DE: The role of embolization and nephrectomy in the treatment of metastatic renal carcinoma. Urol Clin North Am 7 (3): 719-30, 1980.
[PUBMED Abstract]
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