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Mission and Goal
Mission and Goal

The Cancer Genome Atlas (TCGA) is a comprehensive and coordinated effort to accelerate our understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing.
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News from the Pilot Project
News from the Pilot Project

NEW*NCI Announces New Funding to Support TCGA
The National Cancer Institute (NCI) has announced a new funding opportunity to support TCGA. This funding opportunity announcement (FOA) is soliciting applications for Genome Characterizations Centers and Genome Data Analysis Centers. A pre-application meeting for all interested prospective applicants will be held January 29, 2009, in person and via web cast with NCI staff to discuss the goals and objectives for the TCGA Research Network, the application content, and financial questions.
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The Cancer Genome Atlas Reports First Results of Comprehensive Study of Brain Tumors: Large-Scale Effort Identifies New Genetic Mutations, Core Pathways
The Cancer Genome Atlas Research Network reported the first results of its large-scale, comprehensive study of the most common form of brain cancer, glioblastoma (GBM) in the Sept. 4, 2008 advance online edition of the journal Nature. Among the TCGA findings are the identification of many gene mutations involved in GBM, including three previously unrecognized mutations that occur with significant frequency; and the delineation of core pathways disrupted in this type of brain cancer. One of the most exciting results is an unexpected observation that points to a potential mechanism of resistance to a common chemotherapy drug used for brain cancer.
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TCGA Moving Molecular Oncology Forward
The Cancer Genome Atlas (TCGA) pilot project, a collaborative effort between the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), has made valuable progress as new data is continually generated and shared internationally among researchers. With new technologies and tools being developed, TCGA is enabling researchers to delve further into the molecular machinery of cancer with greater precision and efficiency.
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TCGA Data Portal
TCGA Data Portal
Pilot Project to Map Three Cancers
    Access TCGA Data Portal
    View the phase two list of targets to
        be sequenced in glioblastoma
        multiforme (GBM)
TCGA: How Will It Work?
TCGA: How Will It Work?
Click here for more info

Featured Articles
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
TCGA Research Network
October 23, 2008
*Advance online edition released September 4, 2008; final article published in the October 23, 2008 issue of Nature.

Mapping the Cancer Genome
By Francis S. Collins and Anna D. Barker
Scientific American
March 2007

National Cancer InstituteNational Human Genome Research InstituteNational Institutes of HealthDepartment of Health and Human