| | This journal provides immediate access to some articles. Commentary Two important polymers cross paths James A. Spudich PMCID: PMC528761 Perspective Curbing the U.S. carbon deficit Robert B. Jackson and William H. Schlesinger PMCID: PMC528743 Physical Sciences Applied Mathematics The stochastic piston problem G. Lin, C. H. Su, and G. E. Karniadakis PMCID: PMC528754 Applied Physical Sciences Age-related reduction in microcolumnar structure in area 46 of the rhesus monkey correlates with behavioral decline Luis Cruz, Daniel L. Roe, Brigita Urbanc, Howard Cabral, H. E. Stanley, and Douglas L. Rosene PMCID: PMC528765 Heterogeneity explains features of “anomalous” thermodynamics and statistics Stefan Gheorghiu and Marc-Olivier Coppens PMCID: PMC528778 Chemistry Melyrid beetles (Choresine): A putative source for the batrachotoxin alkaloids found in poison-dart frogs and toxic passerine birds John P. Dumbacher, Avit Wako, Scott R. Derrickson, Allan Samuelson, Thomas F. Spande, and John W. Daly PMCID: PMC528779 Computer Sciences Identification of hair cycle-associated genes from time-course gene expression profile data by using replicate variance Kevin K. Lin, Darya Chudova, G. Wesley Hatfield, Padhraic Smyth, and Bogi Andersen PMCID: PMC524696 Engineering From the Cover:
Computerized microfluidic cell culture using elastomeric channels and Braille displays Wei Gu, Xiaoyue Zhu, Nobuyuki Futai, Brenda S. Cho, and Shuichi Takayama PMCID: PMC528755 Geophysics Ferromagnesian postperovskite silicates in the D″ layer of the Earth Wendy L. Mao, Guoyin Shen, Vitali B. Prakapenka, Yue Meng, Andrew J. Campbell, Dion L. Heinz, Jinfu Shu, Russell J. Hemley, and Ho-kwang Mao PMCID: PMC528774 Biological Sciences Biochemistry A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase Frederick Berkovitch, Elham Behshad, Kuo-Hsiang Tang, Eva A. Enns, Perry A. Frey, and Catherine L. Drennan PMCID: PMC528771 Formation of an actin-like filament concurrent with the enzymatic synthesis of inorganic polyphosphate María R. Gómez-García and Arthur Kornberg PMCID: PMC528760 An unusual tryptophanyl tRNA synthetase interacts with nitric oxide synthase in Deinococcus radiodurans Madhavan R. Buddha, Kim M. Keery, and Brian R. Crane PMCID: PMC528745 Mechanisms of ammonia activation and ammonium ion inhibition of quinoprotein methanol dehydrogenase: A computational approach Swarnalatha Y. Reddy and Thomas C. Bruice PMCID: PMC528780 Folding of human superoxide dismutase: Disulfide reduction prevents dimerization and produces marginally stable monomers Mikael J. Lindberg, Johanna Normark, Arne Holmgren, and Mikael Oliveberg PMCID: PMC528748 Computational modeling reveals how interplay between components of a GTPase-cycle module regulates signal transduction Scott J. Bornheimer, Mano R. Maurya, Marilyn Gist Farquhar, and Shankar Subramaniam PMCID: PMC524695 Biophysics EosFP, a fluorescent marker protein with UV-inducible green-to-red fluorescence conversion Jörg Wiedenmann, Sergey Ivanchenko, Franz Oswald, Florian Schmitt, Carlheinz Röcker, Anya Salih, Klaus-Dieter Spindler, and G. Ulrich Nienhaus PMCID: PMC528746 An acoustic microscopy technique reveals hidden morphological defenses in Daphnia Christian Laforsch, Wilfred Ngwa, Wolfgang Grill, and Ralph Tollrian PMCID: PMC528736 Understanding the key factors that control the rate of β-hairpin folding Deguo Du, Yongjin Zhu, Cheng-Yen Huang, and Feng Gai PMCID: PMC528756 Visualization of the movement of single histidine kinase molecules in live Caulobacter cells J. Deich, E. M. Judd, H. H. McAdams, and W. E. Moerner PMCID: PMC528753 Cell Biology From the Cover:
Computerized microfluidic cell culture using elastomeric channels and Braille displays Wei Gu, Xiaoyue Zhu, Nobuyuki Futai, Brenda S. Cho, and Shuichi Takayama PMCID: PMC528755 OPA1 requires mitofusin 1 to promote mitochondrial fusion Sara Cipolat, Olga Martins de Brito, Barbara Dal Zilio, and Luca Scorrano PMCID: PMC528769 In vivo dynamics of chromatin-associated complex formation in mammalian nucleotide excision repair Martijn J. Moné, Tytus Bernas, Christoffel Dinant, Feliks A. Goedvree, Erik M. M. Manders, Marcel Volker, Adriaan B. Houtsmuller, Jan H. J. Hoeijmakers, Wim Vermeulen, and Roel van Driel PMCID: PMC528744 Model for anaphase B: Role of three mitotic motors in a switch from poleward flux to spindle elongation I. Brust-Mascher, G. Civelekoglu-Scholey, M. Kwon, A. Mogilner, and J. M. Scholey PMCID: PMC524698 From the Cover:
Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling Shakil A. Khan, Kwangho Lee, Khalid M. Minhas, Daniel R. Gonzalez, Shubha V. Y. Raju, Ankit D. Tejani, Dechun Li, Dan E. Berkowitz, and Joshua M. Hare PMCID: PMC528749 Developmental Biology Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development Nicholas W. Gale, Melissa G. Dominguez, Irene Noguera, Li Pan, Virginia Hughes, David M. Valenzuela, Andrew J. Murphy, Niels C. Adams, Hsin Chieh Lin, Jocelyn Holash, Gavin Thurston, and George D. Yancopoulos PMCID: PMC524697 Identification of hair cycle-associated genes from time-course gene expression profile data by using replicate variance Kevin K. Lin, Darya Chudova, G. Wesley Hatfield, Padhraic Smyth, and Bogi Andersen PMCID: PMC524696 Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless Chiann-mun Chen, Walter Strapps, Andrew Tomlinson, and Gary Struhl PMCID: PMC528772 Evolution Chicken W: A genetically uniform chromosome in a highly variable genome Sofia Berlin and Hans Ellegren PMCID: PMC528742 Discriminating males alter sperm production between species Andrea S. Aspbury and Caitlin R. Gabor PMCID: PMC528751 Genetics From the Cover:
Identification of alternative splicing regulators by RNA interference in Drosophila Jung W. Park, Katherine Parisky, Alicia M. Celotto, Robert A. Reenan, and Brenton R. Graveley PMCID: PMC528766 Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae Kyungjae Myung, Stephanie Smith, and Richard D. Kolodner PMCID: PMC528767 Centromere-encoded RNAs are integral components of the maize kinetochore Christopher N. Topp, Cathy X. Zhong, and R. Kelly Dawe PMCID: PMC528775 Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas Nicola S. Fearnhead, Jennifer L. Wilding, Bruce Winney, Susan Tonks, Sylvia Bartlett, David C. Bicknell, Ian P. M. Tomlinson, Neil J. McC. Mortensen, and Walter F. Bodmer PMCID: PMC528777 Sir2 mediates longevity in the fly through a pathway related to calorie restriction Blanka Rogina and Stephen L. Helfand PMCID: PMC528752 Immunology Antigen-independent memory CD8 T cells do not develop during chronic viral infection E. John Wherry, Daniel L. Barber, Susan M. Kaech, Joseph N. Blattman, and Rafi Ahmed PMCID: PMC524220 Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: A target for STAT6 but not GATA3 Dong U. Lee and Anjana Rao PMCID: PMC528768 Medical Sciences Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia Ori Brenner, Ditsa Levanon, Varda Negreanu, Olga Golubkov, Ofer Fainaru, Eilon Woolf, and Yoram Groner PMCID: PMC528776 Induction in myeloid leukemic cells of genes that are expressed in different normal tissues Joseph Lotem, Hila Benjamin, Dvir Netanely, Eytan Domany, and Leo Sachs PMCID: PMC528762 From the Cover:
A polymer library approach to suicide gene therapy for cancer Daniel G. Anderson, Weidan Peng, Akin Akinc, Naushad Hossain, Anat Kohn, Robert Padera, Robert Langer, and Janet A. Sawicki PMCID: PMC528737 Microbiology INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of E. P. Greenberg Tinsley H. Davis PMCID: PMC528758 INAUGURAL ARTICLE by a Recently Elected Academy Member: Promoter specificity in Pseudomonas aeruginosa quorum sensing revealed by DNA binding of purified LasR M. Schuster, M. L. Urbanowski, and E. P. Greenberg PMCID: PMC528741 Local modulation of plus-end transport targets herpesvirus entry and egress in sensory axons G. A. Smith, L. Pomeranz, S. P. Gross, and L. W. Enquist PMCID: PMC528757 Different functions of HetR, a master regulator of heterocyst differentiation in Anabaena sp. PCC 7120, can be separated by mutation Ivan Y. Khudyakov and James W. Golden PMCID: PMC528747 Neuroscience Age-related reduction in microcolumnar structure in area 46 of the rhesus monkey correlates with behavioral decline Luis Cruz, Daniel L. Roe, Brigita Urbanc, Howard Cabral, H. E. Stanley, and Douglas L. Rosene PMCID: PMC528765 Dopamine transporters depolarize neurons by a channel mechanism Lucia Carvelli, Paul W. McDonald, Randy D. Blakely, and Louis J. DeFelice PMCID: PMC528740 Cell-density-dependent regulation of neural precursor cell function Charles L. Limoli, Radoslaw Rola, Erich Giedzinski, Sailaja Mantha, Ting-Ting Huang, and John R. Fike PMCID: PMC528770 A clock gene, period, plays a key role in long-term memory formation in Drosophila Takaomi Sakai, Takuya Tamura, Toshihiro Kitamoto, and Yoshiaki Kidokoro PMCID: PMC528738 From the Cover:
A reexamination of the evidence for the somatic marker hypothesis: What participants really know in the Iowa gambling task Tiago V. Maia and James L. McClelland PMCID: PMC528759 Physiology Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism Eric E. Zhang, Emilie Chapeau, Kazuki Hagihara, and Gen-Sheng Feng PMCID: PMC528739 Plant Biology Natural variation in expression of self-incompatibility in Arabidopsis thaliana: Implications for the evolution of selfing M. E. Nasrallah, P. Liu, S. Sherman-Broyles, N. A. Boggs, and J. B. Nasrallah PMCID: PMC528763 Social Sciences Psychology From the Cover:
A reexamination of the evidence for the somatic marker hypothesis: What participants really know in the Iowa gambling task Tiago V. Maia and James L. McClelland PMCID: PMC528759 Corrections Proc Natl Acad Sci U S A. 2004 November 9; 101(45): 16081. doi: 10.1073/pnas.0407104101.PMCID: PMC528773 Corrects: Tobias Willer, et al. Targeted disruption of the Walker–Warburg syndrome gene Pomt1 in mouse results in embryonic lethality. Proc Natl Acad Sci U S A. 2004 September 28; 101(39): 14126–14131. Proc Natl Acad Sci U S A. 2004 November 9; 101(45): 16081. doi: 10.1073/pnas.0407342101.PMCID: PMC528781 Corrects: Alan R. Fersht. Relationship of Leffler (Brønsted) α values and protein folding Φ values to position of transition-state structures on reaction coordinates. Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14338–14342. Proc Natl Acad Sci U S A. 2004 November 9; 101(45): 16081. doi: 10.1073/pnas.0407382101.PMCID: PMC528750 Corrects: A. Thiele, et al. Contribution of inhibitory mechanisms to direction selectivity and response normalization in macaque middle temporal area. Proc Natl Acad Sci U S A. 2004 June 29; 101(26): 9810–9815. Retraction Daniel F. Klessig, Gregory B. Martin, and Sophia K. Ekengren PMCID: PMC528764 Retracts: Meena R. Chandok, et al. Suppression of pathogen-inducible NO synthase (iNOS) activity in tomato increases susceptibility to Pseudomonas syringae. Proc Natl Acad Sci U S A. 2004 May 25; 101(21): 8239–8244. |
