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Lipid Metabolism and the Pathophysiology of Obesity
collage of lipids In the midst of an epidemic of obesity, with many likely and poorly understood causes, NIH has developed a multi-pronged attack on the problem. This workshop supported by NIDDK, NHLBI, NIA, NICHD, NIGMS and ODS will focus attention on how alterations in lipid metabolism and signaling impact the development of obesity and its complications. Lipids, whether derived from the diet or from cellular metabolic activities, play a major role in overall energy balance, and any number of alterations in lipid metabolism may contribute to the disease state. Since lipids are used as sources of fuel for energy production, as structural elements, and as signaling molecules, there are many different levels at which further understanding is needed. For example, little is known about events in specific cells and tissues that lead to greater fat accumulation, alterations in fat deposition, generation of harmful metabolites, and development of specific cellular injuries. This workshop will attempt to define the current state-of-the-art and provide a blueprint for development of new initiatives designed to address the role of lipid metabolism in the obesity epidemic. The invited speakers and attendees will be asked to help provide this blueprint through a variety of inputs, including platform presentations, posters, and discussions.

The organizers welcome any comments regarding the role of the NIH in addressing the obesity epidemic, areas where progress is needed, resources or technologies that are lacking, and ways in which NIDDK, NHLBI, NIA, NICHD, and NIGMS can be most effective.
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