NCBI UniGene banner graphic
PubMed Nucleotide Protein Genome Structure Popset Taxonomy
 Search
NCBI

UniGene
Homepage
FAQs
Query Tips
Library Browser
DDD
Download UniGene

Related Databases
Gene
HomoloGene
dbEST
Trace Archive

NIH cDNA Projects
MGC | ZGC | XGC
Finding cDNAs
UGID:228654     UniGene Hs.433222     Homo sapiens (human)   NPC2 Order cDNA clone, Links
Niemann-Pick disease, type C2 (NPC2)
SELECTED PROTEIN SIMILARITIES
Comparison of sequences in UniGene with selected protein reference sequences. The alignments can suggest function of a gene.
Reference ProteinSpeciesId(%)Len(aa)
XP_001094066.1 PREDICTED: similar to Epididymal secretory protein E1 precursor (Niemann-Pick disease type C2 protein) (hE1) M. mulatta 100.0 150
NP_001009075.1 epididymal secretory protein E1 P. troglodytes 100.0 150
NP_006423.1 epididymal secretory protein E1 precursor H. sapiens 100.0 150
NP_075898.1 epididymal secretory protein E1 M. musculus 86.6 148
NP_001084605.1 hypothetical protein LOC414558 X. laevis 71.4 147
NP_775331.1 epididymal secretory protein E1 D. rerio 69.9 145

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Expression Profile: View expression levels using UniGene's EST ProfileViewer
[Show more entries with profiles like this]
Note: Highly represented in several libraries
GEO profiles: Gene expression profiles in the NCBI Gene Expression Omnibus database
cDNA Sources: pancreas; lung; uncharacterized tissue; brain; uterus; skin; testis; eye; mixed; placenta; mammary gland; bone; heart; epididymis; intestine; stomach; embryonic tissue; pharynx; prostate; spleen; umbilical cord; liver; ovary; kidney; connective tissue; thyroid; lymph node; esophagus; mouth; bladder; pituitary gland; blood; vascular; adrenal gland; parathyroid; ear; larynx; amniotic fluid; cervix; thymus; salivary gland; tonsil; ascites; adipose tissue; muscle; bone marrow; pineal gland; nerve
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 14
Map position: 14q24.3
UniSTS entry: Chr 14 RH70872 [Map Viewer]
UniSTS entry: Chr 14 SHGC-132103
UniSTS entry: Chr 14 SHGC-12718
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (14)

NM_006432.3 Homo sapiens Niemann-Pick disease, type C2 (NPC2), mRNA PA
CR624497.1 full-length cDNA clone CS0DD002YK19 of Neuroblastoma Cot 50-normalized of Homo sapiens (human) P
CR622486.1 full-length cDNA clone CS0DI067YF02 of Placenta Cot 25-normalized of Homo sapiens (human) P
CR609490.1 full-length cDNA clone CS0DL002YA08 of B cells (Ramos cell line) Cot 25-normalized of Homo sapiens (human) P
CR608935.1 full-length cDNA clone CS0DK006YB03 of HeLa cells Cot 25-normalized of Homo sapiens (human) P
CR605546.1 full-length cDNA clone CS0DI086YJ17 of Placenta Cot 25-normalized of Homo sapiens (human) P
CR601885.1 full-length cDNA clone CS0DI063YB07 of Placenta Cot 25-normalized of Homo sapiens (human) P
CR595914.1 full-length cDNA clone CS0DC012YD03 of Neuroblastoma Cot 25-normalized of Homo sapiens (human) P
AK222474.1 Homo sapiens mRNA for Niemann-Pick disease, type C2 precursor variant, clone: adKA02874 P
BC002532.2 Homo sapiens Niemann-Pick disease, type C2, mRNA (cDNA clone MGC:1333 IMAGE:3140870), complete cds PA
AK311931.1 Homo sapiens cDNA, FLJ92198, highly similar to Homo sapiens Niemann-Pick disease, type C2 (NPC2), mRNA P
AK300879.1 Homo sapiens cDNA FLJ59142 complete cds, highly similar to Epididymal secretory protein E1 precursor P
AK298975.1 Homo sapiens cDNA FLJ51947 complete cds, highly similar to Epididymal secretory protein E1 precursor P
X67698.1 H.sapiens tissue specific mRNA PA

EST sequences (10 of 1045) [Show all sequences]

AA971460.1 Clone IMAGE:1583248 mixed 3' read A
AA977956.1 Clone IMAGE:1592350 kidney 3' read PA
AA992934.1 Clone IMAGE:1624973 embryonic tissue 3' read P
AA993826.1 Clone IMAGE:1624361 embryonic tissue 5' read P
AI000634.1 Clone IMAGE:1609265 mammary gland 3' read A
AA909283.1 Clone IMAGE:1540994 mixed 3' read A
AA923554.1 Clone IMAGE:1536222 kidney 3' read A
AI017752.1 Clone IMAGE:1638990 testis 3' read PA
AI034134.1 Clone IMAGE:1646861 parathyroid 3' read PA
AI074223.1 Clone IMAGE:1682092 skin 3' read PA


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
NLM | NIH | UniGene | Privacy Statement | Disclaimer | NCBI Help