National Toxicology Program

CASRN: 103-33-3

Formula: C12 H10 N2

Synonyms/Common Names:

• DIPHENYLDIAZENE

Known Uses:

INTERMEDIATE FOR AZO DYES AND OTHER ORGANIC CHEMICALS, ACARICIDE (MERCK 1989)

Short-Term Toxicity

• 13-WEEK (Dosed-Feed)  (C02926) Completed 
  • NTIS No. PB293835  (Peer Review 12/13/1978)
    Citation: Bioassay of Azobenzene for Possible Carcinogenicity (CAS No. 103-33-3)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,500,4600 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C02926) Report Complete 
  • TR-154 (NTIS No. PB293835)  (Peer Review 12/13/1978)
    Bioassay of Azobenzene for Possible Carcinogenicity (CAS No. 103-33-3)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R&MM: 0,200,400, FM: 0,208,545 (AVG) PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (657475) Completed 
  • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• In Vitro Cytogenetics (CA/SCE)  (758475) Completed 
  • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
  • Chromosome Aberation Inconclusive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (165449) Completed 
  • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Salmonella  (218794) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive 
• Salmonella  (513062) Completed 
  •  Positive 
• Salmonella  (514794) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive