Summaries & Associations of Study Results
Levels from TR-513 Decalin
Target Organs and Levels of Evidence
NTP Technical Report Number 513
Produced from Chemtrack Database 02/07/06
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| DECALIN 91-17-8 |
09/05/02 | RESEARCH CHEMICAL, SOLVENT FOR NAPHTHALENE, FATS, RESINS, OILS, IN MOTOR FUEL & LUBRICANTS. | Inhalation M&F MICE AND FEMALE RATS: 0, 25, 100, OR 400 PPM MALE RATS: 0, 25, 50, 100, OR 400 PPM (20 MALES); 50/SEX/SPECIES/GROUP | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | KIDNEY TUBULAR CELL: ADENOMA 1/50 2/50 6/49 9/50 5/20 ADENOMA OR CARCINOMA 1/50 3/50 7/49 12/50 6/20 | |||
| ADRENAL MEDULLA: BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 8/49 9/49 13/49 16/49 8/20 | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: SEVERITY OF CHRONIC NEPHROPATHY; TUBULE HYPERPLASIA; HYALINE DROPLET ACCUMULATION; PAPILLA MINERALIZATON; PELVIC TRANSITIONAL EPITHELIAL HYPERPLASIA | |||
| FR: NO EVIDENCE | ||||
| MM: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: EOSINOPHILIC FOCUS; CENTRILOBULAR HYPERTROPHY; NECROSIS; SYNCYTIAL ALTERATION; ERYTHROPHAGOCYTOSIS | |||
| FM: EQUIVOCAL EVIDENCE | ||||
| MAY HAVE BEEN RELATED: | LIVER: ADENOMA 7/49 13/50 8/50 17/50 CARCINOMA 4/49 16/50 6/50 5/50 COMBINED 11/49 27/50 14/50 20/50 | |||
| UTERUS: STROMAL POLYP 0/49 0/50 2/50 3/50 STROMAL POLYP OR STROMAL SARCOMA 0/49 0/50 2/50 4/50 | ||||
Web page last updated on February 10, 2006
