Study Results & Research Projects

Summaries & Associations of Study Results

Levels from TR-537 Water Disinfection Byproducts (Dibromoacetic Acid)

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http://ntp.niehs.nih.gov/go/18971

Target Organs and Levels of Evidence
NTP Technical Report Number 537

Produced from Chemtrack Database 01/04/06

CHEMICAL/ CAS NUMBER PEER REVIEW DATE PRIMARY USES ROUTE/EXPOSURE LEVELS STUDY LABORATORY
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
631-64-1   		09/27/05 A BYPRODUCT OF WATER CHLORINATION Dosed-Water R&M: 0, 50, 500, OR 1000 MG/L; 50/SEX/SPECIES Southern Research Institute
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM):
MR: SOME EVIDENCE ALL ORGANS: MALIGNANT MESOTHELIOMA 3/50 1/50 0/50 10/50
NON-NEOPLASTIC LESIONS: LIVER: CYSTIC DEGENERATION
FR: SOME EVIDENCE ALL ORGANS: MONONUCLEAR CELL LEUKEMIA 11/50 13/50 16/50 22/50
NON-NEOPLASTIC LESIONS: LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA
  KIDNEY: NEPHROPATHY
MM: CLEAR EVIDENCE LIVER: ADENOMA 18/49 37/50 37/50 42/50 CARCINOMA 14/49 9/50 19/50 26/50 COMBINED 28/49 41/50 42/50 47/50 HEPATOBLASTOMA 0/49 4/50 6/50 18/50
  LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 7/49 5/50 17/50 12/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 12/49 12/50 22/50 17/50
NON-NEOPLASTIC LESIONS: SPLEEN: HEMATOPOIESIS
FM: CLEAR EVIDENCE LIVER: ADENOMA 19/49 26/50 32/50 35/49 CARCINOMA 3/49 3/50 12/50 8/49 COMBINED 22/49 28/50 37/50 37/49
MAY HAVE BEEN RELATED: LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 3/50 3/50 6/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 2/50 5/50 5/50 7/50

 

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Web page last updated on September 06, 2007