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UGID:230089     UniGene Hs.435052     Homo sapiens (human)   ATP8A1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 (ATP8A1)
SELECTED PROTEIN SIMILARITIES
Comparison of sequences in UniGene with selected protein reference sequences. The alignments can suggest function of a gene.
Reference ProteinSpeciesId(%)Len(aa)
NP_006086.1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 isoform a H. sapiens 100.0 1163
XP_001099138.1 PREDICTED: similar to ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 M. mulatta 99.9 1163
XP_001150768.1 PREDICTED: ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 isoform 1 P. troglodytes 99.9 1163
NP_001034088.1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 isoform a M. musculus 98.7 1163
NP_610873.1 CG17034 CG17034-PD, isoform D D. melanogaster 63.9 1112
NP_001022894.1 Transbilayer Amphipath Transporters (subfamily IV P-type ATPase) family member (tat-1) C. elegans 56.6 1110
XP_322438.1 hypothetical protein N. crassa 54.3 1117
NP_009376.1 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease; Drs2p S. cerevisiae 51.3 1118
XP_691903.2 PREDICTED: similar to Potential phospholipid-transporting ATPase ID (ATPase class I type 8B member 2) D. rerio 47.9 1100
NP_176191.1 haloacid dehalogenase-like hydrolase family protein A. thaliana 47.8 1101

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Expression Profile: View expression levels using UniGene's EST ProfileViewer
[Show more entries with profiles like this]
GEO profiles: Gene expression profiles in the NCBI Gene Expression Omnibus database
cDNA Sources: brain; uncharacterized tissue; embryonic tissue; eye; kidney; pancreas; lymph node; mixed; muscle; prostate; pharynx; placenta; adrenal gland; pituitary gland; blood; mouth; esophagus; spleen; thymus; parathyroid; vascular; liver; intestine; uterus; testis; connective tissue; ear; lymph; skin; nerve; stomach; lung; ovary; bone; adipose tissue; pineal gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 4
Map position: 4p14-p12
UniSTS entry: Chr 4 D4S3277
UniSTS entry: Chr 4 SHGC-59604
UniSTS entry: Chr 4 (n/a)
UniSTS entry: Chr 4 WI-19830
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (12)

AB013452.1 Homo sapiens mRNA for ATPaseII, complete cds P
BX648675.1 Homo sapiens mRNA; cDNA DKFZp686C1850 (from clone DKFZp686C1850) PA
AB209687.1 Homo sapiens mRNA for ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 variant protein P
AK027252.1 Homo sapiens cDNA: FLJ23599 fis, clone LNG15473, highly similar to AF035315 Homo sapiens clone 23664 and 23905 mRNA sequence A
BC109318.1 Homo sapiens ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1, mRNA (cDNA clone MGC:130043 IMAGE:40036538), complete cds P
BC109317.1 Homo sapiens ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1, mRNA (cDNA clone MGC:130042 IMAGE:40036536), complete cds P
NM_006095.2 Homo sapiens ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 (ATP8A1), transcript variant 1, mRNA PA
NM_001105529.1 Homo sapiens ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 (ATP8A1), transcript variant 2, mRNA PA
AK295616.1 Homo sapiens cDNA FLJ61275 complete cds, highly similar to Probable phospholipid-transporting ATPase IA(EC 3.6.3.1) P
BC020943.1 Homo sapiens ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1, mRNA (cDNA clone IMAGE:4816327), complete cds PA
AF067820.1 Homo sapiens ATPase II mRNA, partial cds P
AF035315.1 Homo sapiens clone 23664 and 23905 mRNA sequence A

EST sequences (10 of 253) [Show all sequences]

AI026127.1 Clone IMAGE:1647356 parathyroid 3' read A
AI033689.1 Clone IMAGE:1647978 parathyroid 3' read A
AI041510.1 Clone IMAGE:1648865 parathyroid 3' read A
BX089396.1 Clone IMAGp998B2474_;_IMAGE:23877 brain A
BX089438.1 Clone IMAGp998D03730_;_IMAGE:322514 parathyroid
AI204896.1 Clone IMAGE:1684742 brain 3' read
AI218581.1 Clone IMAGE:1845168 mixed 3' read A
AI267759.1 Clone IMAGE:2022328 brain
R38285.1 Clone IMAGE:23877 brain 3' read A
AI367652.1 Clone IMAGE:1934553 embryonic tissue 3' read


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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