3D Reconstruction of Individual Senile Plaques Just Below the Surface of the Brain [8 seconds]
This is a side-on view of methoxy-XO4-labeled plaques in a volume of brain immediately under the imaging window in an Alzheimer’s disease mouse model. The field of view is about 600x600 microns, and 250 microns deep. Multiphoton microscopy allows high-resolution imaging of fluorescence deep within the living brain.
Brian Bacskai, Ph.D.
Massachusetts General Hospital
