Summaries & Associations of Study Results
TR-497 Methacrylonitrile
Target Organs and Levels of Evidence
NTP Technical Report Number 497
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| METHACRYLONITRILE 126-98-7 |
05/03/01 | HOMO- AND CO-POLYMERS, ELASTOMERS, COATINGS AND PLASTICS. CHEMICAL INTERMEDIATE. REPLACEMENT FOR ACRYLONITRILE IN CERTAIN USES. (NTP EXECUTIVE SUMMARY) | Gavage RATS: 0, 3, 10, OR 30 MG/KG MICE: 0, 1.5, 3, OR 6 MG/KG; 50/SEX/DOSE/SPECIES | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: (OLFACTORY EPITHELIUM) ATROPHY; METAPLASIA | |||
| LIVER: CYTOPLASMIC VACUOLIZATION | ||||
| FR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: (OLFACTORY EPITHELIUM) ATROPHY; METAPLASIA | |||
| LIVER: CYTOPLASMIC VACUOLIZATION | ||||
| MM: NO EVIDENCE | ||||
| FM: NO EVIDENCE | ||||
Web page last updated on February 10, 2006
