Summaries & Associations of Study Results
TR-478 Diethanolamine
Target Organs and Levels of Evidence
NTP Technical Report Number 478
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| DIETHANOLAMINE 111-42-2 |
12/10/97 | IN PRODUCTION OF TEXTILE LUBRICANTS. RUBBER CHEMICALS INTERMEDIATE. EMULSIFIER IN AGRICULTURAL CHEMICALS, COSMETICS, AND PHARMACEUTICALS. GAS CONDITIONING AGENT. (TDB) | Topical MR: 0, 16, 32, OR 64 MG/KG; FR: 0, 8, 16, OR 32 MG/KG; MICE: 0, 40, 80, OR 160 MG/KG (50/SEX/SPECIES/GROUP) | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | SKIN: ACANTHOSIS; HYPERKERATOSIS | |||
| FR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | SKIN: HYPERKERATOSIS | |||
| KIDNEY: INCREASED SEVERITY OF NEPHROPATHY | ||||
| MM: CLEAR EVIDENCE | LIVER: ADENOMA 31/50 42/50 49/50 45/50, CARCINOMA 12/50 17/50 33/50 34/50 OR HEPATOBLASTOMA 0/50 2/50 8/50 5/50 | |||
| KIDNEY TUBULAR CELL: (SINGLE SECTIONS) ADENOMA 1/50 4/50 6/50 6/50 COMBINED 3/50 5/50 6/50 8/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 6/50 8/50 7/50 COMBINED 3/50 7/50 8/50 9/50 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: CYTOPLASMIC ALTERATION; SYNCYTIAL ALTERATION | |||
| KIDNEY: TUBULE HYPERPLASIA | ||||
| THYROID GLAND: FOLLICULAR CELL HYPERPLASIA | ||||
| SKIN: HYPERKERATOSIS | ||||
| FM: CLEAR EVIDENCE | LIVER: ADENOMA 32/50 50/50 48/50 48/50 OR CARCINOMA 5/50 19/50 38/50 42/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: SYNCYTIAL ALTERATION | |||
| THYROID GLAND: FOLLICULAR CELL HYPERPLASIA | ||||
| SKIN: HYPERKERATOSIS | ||||
Web page last updated on February 10, 2006
