Testing Status of Agents at NTP
Diisopropylcarbodiimide
CASRN: 693-13-0
Formula: C7-H14-N2
Synonyms/Common Names:
- DIC
- 1,3-DIISOPROPYLCARBODIIMIDE
- N,N'-DIISOPROPYLCARBODIIMIDE
Known Uses:
AS A PEPTIDE COUPLING REAGENT; AS A CONDENSING REAGENT IN DIPEPTIDE SYNTHESIS; IN PREPARATION OF POLYIMIDE PRECURSOR COATINGS FOR ELECTROPHORETIC IMAGE DISPLAY FABRICATION; AS A MILITARY NERVE AGENT STABILIZER.
Nomination Background
Short-Term Toxicity
- 2-WEEK (Topical Application)
(C93020) Completed
- NTIS No. PB2007107705
(Peer Review 09/28/2005)
Citation: Toxicology and Carcinogenesis Studies of Diisopropylcarbodiimide (CAS No. 693-13-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 10, 30, 90, 269, OR 806 MG/ML; 5/SEX/SPECIES/GROUP
- NTIS No. PB2007107705
(Peer Review 09/28/2005)
- 21-WEEK (Topical Application)
(C93020B) Report Complete
- (Peer Review 09/28/2005) Citation: Toxicology Study of Diispropylcarbodiimide (CAS No. 693-13-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Dermal Studies)
- Mice: Tg.AC (FVB/N) Hemizygous
- Dose: FEMALE MICE: 0, 4.38, 8.75, 17.5, 35, OR 70 MG/KG; 10/GROUP
- 27-WEEK (Topical Application)
(C93020C) Report Complete
- (Peer Review 09/28/2005) Citation: Toxicology Study of Diispropylcarbodiimide (CAS No. 693-13-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Dermal Studies)
- Mice: P53 +/- (C57BL/6)
- Dose: FEMALE MICE: 0, 4.38, 8.75, 17.5, 35, OR 70 MG/KG; 15/GROUP
- 13-WEEK (Topical Application)
(C93020) Report Complete
- NTIS No. PB2007107705
(Peer Review 09/28/2005)
Citation: Toxicology and Carcinogenesis Studies of Diisopropylcarbodiimide (CAS No. 693-13-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 10, 20, 40, 80, OR 160 MG/KG M: 0, 17.5, 35, 70, 140, OR 280 10 SEX/SPECIES/GROUP, 6 GROUPS
- NTIS No. PB2007107705
(Peer Review 09/28/2005)
Long-Term Carcinogenicity
- 2-YEAR (Topical Application)
(C93020D) Report Complete
- TR-523 (NTIS No. PB2007107705)
(Peer Review 09/28/2005)
Toxicology and Carcinogenesis Studies of Diisopropylcarbodiimide (CAS No. 693-13-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R&M: 0, 10, 20, OR 40 MG/KG; 50/SEX/SPECIES
- TR-523 (NTIS No. PB2007107705)
(Peer Review 09/28/2005)
Special Studies
- Absorption Disposition Metabolism Elimination (Topical Application; Intravenous)
(S0662) Completed
- Citation: "DISPOSITION OF DERMALLY AND IV ADMINISTERED [14C]DIISOPROPYLCARBODIIMIDE IN FISCHER 344 RATS AND B6C3F1 MICE" 1/4/99
- M Rats: F344/N; M Mice: B6C3F1; M Rats: F344/N
- Dose: dermal: 4-42 mg/kg (rats); 7-82 mg/kg (mice) IV: 8 mg/kg (dose vol. 1.3 ml/kg) (mice-only) for dermal needed to use charcoal-impregnated cellulose filters
Genetic Toxicology
- Micronucleus
(A04322) Completed
- Citation: Witt, K.L., Tice, R.R., Shelby, M.D., Chhabra, R.S., and Zeiger, E. Induction of Micronucleated Erythrocytes in Rodents by Diisopropylcarbodiimide and Dicyclohexylcarbodiimide: Dependence on Exposure Protocol. Environ. Molec. Mutag. Vol. 33 (1999) 65-74
- Mice: B6C3F1
- Male Inconclusive
- Micronucleus
(A22799) Completed
- Citation: Witt, K.L., Tice, R.R., Shelby, M.D., Chhabra, R.S., and Zeiger, E. Induction of Micronucleated Erythrocytes in Rodents by Diisopropylcarbodiimide and Dicyclohexylcarbodiimide: Dependence on Exposure Protocol. Environ. Molec. Mutag. Vol. 33 (1999) 65-74
- Mice: B6C3F1
- Male Positive
- Female Positive
- Micronucleus
(A55884) Completed
- Citation: Witt, K.L., Tice, R.R., Shelby, M.D., Chhabra, R.S., and Zeiger, E. Induction of Micronucleated Erythrocytes in Rodents by Diisopropylcarbodiimide and Dicyclohexylcarbodiimide: Dependence on Exposure Protocol. Environ. Molec. Mutag. Vol. 33 (1999) 65-74
- Mice: B6C3F1
- Male Positive
- Micronucleus
(A76999) Completed
- Citation: Witt, K.L., Tice, R.R., Shelby, M.D., Chhabra, R.S., and Zeiger, E. Induction of Micronucleated Erythrocytes in Rodents by Diisopropylcarbodiimide and Dicyclohexylcarbodiimide: Dependence on Exposure Protocol. Environ. Molec. Mutag. Vol. 33 (1999) 65-74
- Rats: F344
- Male Negative
- Salmonella
(A69920) Completed
- Inconclusive
- Salmonella
(A92772) Completed
- Negative
Organ Systems Toxicity
- 4 DAYS Immunotoxicity (Topical Application)
(IMM95010) Completed
- F Mice: B6C3F1
- Dose: .03, .15, .3, 1.5, AND 3% DIC IN ACETONE (99.8%) FOR SENSIZATION, AND 10% DIC FOR CHALLENGE IN THE MEST AND 1.5, 3 AND 10% DIC IN THE LLNA. .25% DNFB USED AS POSITIVE CONTROL FOR SENSITIZATION, AND .5% FOR CHALLENGE.
Web page last updated on January 22, 2009