Research Interests
Statistical analysis of genomic data,
biomarker evaluation, laboratory quality control, assay reliability,
spatial statistics, measurement error adjustment methods.
Selected Recent
Publications
As of May 15, 2003
McShane, L.M., M. Kulldorff, M.J. Wargovich, C. Woods,
M. Purewal, L.S. Freedman, D.K. Corle, R.W. Burt, D.J. Mateski, M.
Lawson, E. Lanza, B. O'Brien, W. Lake, Jr., J. Moler, A. Schatzkin.
An Evaluation of Rectal Mucosal Proliferation Measure Variability
Sources in the Polyp Prevention Trial: Can We Detect Informative Differences
Among Individuals' Proliferation Measures Amid the Noise? Cancer
Epidemiology, Biomarkers & Prevention 7(7): 605-612, 1998.
Brown, P., L. Cervenakova, L. McShane, P. Kleihues,
J-F. Foncin, G. Collins, F. Bastian, L.G. Goldfarb, and D.C. Gajdusek.
Polymorphic Genotype Matching in Acquired Creutzfeldt-Jakob Disease:
An Analysis of Donor/Recipient Case Pairs. In: Prions and Brain
Diseases in Animals and Humans, Morrison D. R. O., ed. NATO ASI
Series A: Life Sciences, v. 295. Plenum Press, New York, 1998, pp.
19-24.
Brown, P., L. Cervenakova, L. McShane, L.G. Goldfarb, K. Bishop, F.
Bastian, J. Kirkpatrick, P. Piccardo, B. Ghetti, and D.C. Gajdusek.
Creutzfeldt-Jakob Disease in a Husband and Wife. Neurology
50(3): 684-688, 1998.
Ferris, D.G., J.T. Cox, L. Burke, M.S. Litaker, D.M. Harper, M.J.
Campion, M.D. Greenberg, L. McShane, L.M. Wun. Colposcopy Quality
Control: Establishing Colposcopy Criterion Standards for the National
Cancer Institute ALTS Trial Using Cervigrams. Journal of Lower
Genital Tract Disease 2: 195-203, 1998.
Dorgan, J.F., D. Albanes, J. Virtamo, O.P. Heinonen, D.W. Chandler,
M. Galmarini, L.M. McShane, M.J. Barrett, J. Tangrea, P.R. Taylor.
Relationships of Serum Androgens and Estrogens to Prostate Cancer
Risk: Results from a Prospective Study in Finland. Cancer Epidemiology,
Biomarkers & Prevention 7: 1069-1074, 1998.
Hildesheim, A., L.M. McShane, M. Schiffman, M.C. Bratti, A.C. Rodriguez,
R. Herrero, L.A. Morera, F. Cardenas, L. Saxon, F.P. Bowman, P.A.
Crowley-Nowick. Cytokine and Immunoglobulin Levels in Cervical Secretions:
Reproducibility of a Collection Instrument and Correlates of Immune
Measures. Journal of Immunological Methods 225(1-2): 131-143,
1999.
Brown, P., L. Cervenakova, L.M. McShane, P. Barber, R. Rubenstein,
W.N. Drohan. Further Studies of Blood Infectivity in an Experimental
Model of Transmissible Spongiform Encephalopathy, with an Explanation
of Why Blood Components do not Transmit Creutzfeldt-Jakob Disease
in Humans. Transfusion 39: 1169-1178, 1999.
McShane, L.M., R. Aamodt, C. Cordon-Cardo, R. Cote,
D. Faraggi, Y. Fradet, H.B. Grossman, A. Peng, S.E. Taube, F.M. Waldman,
and the National Cancer Institute Bladder Tumor Marker Network. Reproducibility
of p53 Immunohistochemistry in Bladder Tumors. Clinical Cancer
Research 6(5): 1854-1864, 2000.
Kulldorff, M., L.M. McShane, A. Schatzkin, L.S. Freedman, M.J. Wargovich,
C. Woods, M. Purewal, R.W. Burt, M. Lawson, D.J. Mateski, E. Lanza,
D.K. Corle, B. O'Brien, J. Moler. Measuring Cell Proliferation in
the Rectal Mucosa: Comparing Bromodeoxyuridine (BrdU) and Proliferating
Cell Nuclear Antigen (PCNA) Assays. Journal of Clinical Epidemiology
53(8): 875-883, 2000.
Pajak, T.F., G.M. Clark, D.J. Sargent, L. McShane, E. Hammond. Statistical
Issues in Tumor Marker Studies. Archives of Pathology and Laboratory
Medicine 124(7): 1011-1015, 2000.
Brown, P., M. Preece, J-P Brandel, T. Sato, L. McShane,
L. Cervenakova, I. Zerr, R.G. Will, A. Fletcher, M. Pocchiari, N.
Cashman, J.H. d’Aignaux, J. Fradkin, L. Schonberger, S.J. Collins.
Iatrogenic Creutzfeldt-Jakob Disease at the Millennium. Neurology
55(8): 1075-1081, 2000.
Blegen, H., N. Einhorn, K. Sjovall, A. Roschke, B.M.
Ghadimi, L.M. McShane, B. Nilsson, K. Shah, T. Ried, G. Auer. Prognostic
Significance of Cell Cycle Proteins and Genomic Instability in Borderline,
Early- and Advanced Stage Ovarian Carcinomas International Journal
of Gynecologic Cancer 10(6): 477-487, 2000.
McShane, L.M., D.N. Midthune, J.F. Dorgan, L.S. Freedman,
R.J. Carroll. Covariate Measurement Error Adjustment for Matched Case-Control
Studies. Biometrics 57(1): 62-73, 2001.
Albert, P.S., L.M. McShane, J.H. Shih. Latent Modeling
Approaches for Assessing Diagnostic Error Without a Gold Standard:
With Applications to p53 Immunohistochemical Assays in Bladder Tumors.
Biometrics 57(2): 610-619, 2001.
McShane, L.M. and R. Simon. Statistical methods for
the analysis of prognostic factor studies, In Prognostic Factors
in Cancer, Gospodarowicz, Henson, Hutter, O’Sullivan, Sobin and
Wittekind (eds.), 2001.
Albert, P.S., L.M. McShane, E.L. Korn. Design of
a binary biomarker study from the results of a pilot study. Biometrics,
58: 576-585, 2002.
Korn, E.L., L.M. McShane, J.F. Troendle, A. Rosenwald,
R. Simon. Identifying pre-post chemotherapy differences in gene expression
in breast tumours: a statistical method appropriate for this aim.
British Journal of Cancer 86(7): 1093-1096, 2002.
Radmacher, M.D., L.M. McShane, R. Simon. A paradigm
for class prediction using gene expression profiles. Journal of
Computational Biology 9(3): 505-511, 2002.
McShane, L.M., M.D. Radmacher, B. Freidlin, R. Yu,
M. Li, R. Simon. Methods for assessing reproducibility of clustering
patterns observed in analyses of microarray data. Bioinformatics
18(11): 1462-1469, 2002.
Miller, L.D., P.M. Long, L. Wong, S. Mukherjee, L.M.
McShane, E.T. Liu. Optimal gene expression analysis by microarrays.
Cancer Cell, 2(5): 353-361, 2002.
McShane, L.M. Statistical Issues in the Analysis
of Microarray Data. Proceedings of the XXIst International Biometric
Conference 2002, Freiburg, Germany, July 2002.
Simon, R., M.D. Radmacher, K. Dobbin, L.M. McShane.
Pitfalls in the analysis of DNA microarray data for diagnostic and
prognostic classification. Journal of the National Cancer Institute,
95(1): 14-18, 2003.
Korn, E.L., J.F. Troendle, L.M. McShane, R. Simon.
Controlling the number of false discoveries: application to high-dimensional
genomic data. Journal of Statistical Planning and Inference
(in press).
brb@linus.nci.nih.gov