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Approved-By: [log in to unmask] Content-class: urn:content-classes:message Content-Type: multipart/alternative; Thread-Topic: Millennium Promise Awards: Non-communicable Chronic Diseases Research Training Program (NCoD) (D43) DEADLINE September 29, 2008 thread-index: AcjpAtvxXUib48EkQ52bt38AsVxmjg== Message-ID: <[log in to unmask]> Date: Fri, 18 Jul 2008 14:19:47 -0400 Reply-To: Brain research in developing countries <[log in to unmask]> Sender: Brain research in developing countries <[log in to unmask]> From: "Michels, Kathleen (NIH/FIC) [E]" <[log in to unmask]> Subject: Millennium Promise Awards: Non-communicable Chronic Diseases Research Training Program (NCoD) (D43) DEADLINE September 29, 2008 Comments: To: [log in to unmask], List FIRCA-L <[log in to unmask]>, List STIGMA-L <[log in to unmask]>NEW D43 RESEARCH TRAINING PROGRAM opportunity for Non-communicable Chronic Diseases Research Training for Low and middle-income country scientists. http://www.fic.nih.gov/programs/training_grants/ncod/index.htm ************************************************************************************************************ http://www.fic.nih.gov/programs/training_grants/ncod/index.htm Title: Millennium Promise Awards: Non-communicable Chronic Diseases Research Training Program (NCoD) (D43) Program Announcement (PA) Number: PAR-08-175 http://grants.nih.gov/grants/guide/pa-files/PAR-08-175.html Letters of Intent Receipt Date(s): August 31, 2008; August 31, 2009; August 31, 2010 Application Receipt Dates(s):September 29, 2008; September 29, 2009; September 28, 2010 Executive Summary This research training program is designed to build research capacity in low- and middle-income countries (LMICs) in the fields related to cancer, cerebrovascular disease including stroke, lung disease including chronic obstructive pulmonary disease (COPD) and environmental factors including indoor air pollution, and obesity and lifestyle factors related to these conditions as well as genetics of non-communicable diseases. The institutions applying can be domestic or foreign, but have to exhibit the ability to do such training, and must exhibit that they have existing research programs in these fields. * Purpose. This is a Funding Opportunity Announcement (FOA) for a research training program related to chronic, non-communicable diseases to help build capacity for research in LMICs, so-called "developing countries" as defined by the World Bank, (http://www.worldbank.org/data/countryclass/classgroups.htm). * Mechanism of Support. This FOA will utilize the D43 grant mechanism. * Budget and Project Period. For this funding opportunity, budgets up to $220,000 total direct costs per year and time periods up to five years may be requested Research Training Objectives This is a funding opportunity announcement for a research training program related to chronic, non-communicable diseases to help build capacity for future local research in LMICs. This responds to a number of goals in the new FIC strategic plan (http://www.fic.nih.gov/about/plan/strategicplan_08-12.htm). The research areas include cancer, cerebrovascular disease including stroke, lung disease including chronic obstructive pulmonary disease (COPD), obesity as well as genetics, environmental factors including indoor air pollution, and lifestyle factors related to these conditions. The research that these trainees would be associated with is expected to be of importance in the participating LMICs. Burden of Disease Chronic non-communicable diseases are steadily increasing around the world and in LMICs, which will soon account for more than 50% of the expenditures for health care and more than 50% of the disability adjusted life years (DALYs). According to the Disease Control Priorities Project and World Health Organization (WHO), 44% of adult disease burden in LMICs is now attributable to non-communicable diseases and is projected to increase to 54% by 2030. The proposed "Grand Challenges in Chronic Non-Communicable Diseases," developed through an extensive international consensus process, clearly shows the imperative to address these problems now. (Daar AS, et al., Nature, 450 (22 Nov 2007): 494-496. <http://www.nature.com/nature/journal/v450/n7169/full/450494a.html> ) As the origin of and potential solutions to most chronic diseases are complex in nature, programs that strive to develop and provide training across disciplines (e.g., bridging biological, social, and behavioral sciences) are strongly encouraged. In addition to generating evidence to prevent and treat chronic diseases, it is imperative that the research findings be incorporated into community practice in an efficient and timely manner. In fact, we face a formidable gap between innovations in health (including vaccines, drug discovery and strategies for care) and their delivery to communities in LMICs (Madon T <http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%2522Madon%20T%2522%255BAuthor%255D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1> , Hofman KJ <http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%2522Hofman%20KJ%2522%255BAuthor%255D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1> , Kupfer L <http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%2522Kupfer%20L%2522%255BAuthor%255D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1> , Glass RI <http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%2522Glass%20RI%2522%255BAuthor%255D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1> . Public Health. Implementation Science. Science. 2007 Dec 14;318(5857):1728-9) <http://www.ncbi.nlm.nih.gov/pubmed/18079386?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum> . Training researchers in the nascent field of implementation and dissemination science would be appropriate under this announcement. Risk factors for chronic non-communicable disease are complex. Many of the key important risk factors are the social determinants like physical inactivity, poor diet, tobacco smoking and factors which lead to obesity. However, the interactions between genetic and environmental risk factors are critical in the ontogeny of many non-communicable diseases. Furthermore, it is critical to develop a deeper understanding of the complex motivations that contribute to risky behavior in a resource poor setting. These factors can have a profound effect on how risk factors are perceived and incorporated into people's decision making processes and ultimately their behavior. According to WHO's estimation, death from stroke each year in LMICs accounted for more than 85% of stroke death world-wide. The number of DALYs caused by stroke in LMICs was also seven times higher than the number in high-income countries (HICs). The National Institute of Neurological Disorders and Stroke (NINDS) is interested in supporting research training in mechanistic, epidemiological, prevention, translational and clinical research in the areas of stroke. Lung disease due to cigarette smoke (direct or indirect) or especially indoor air pollution at work or at home is rapidly increasing in both adults and children. WHO estimates by 2030, COPD will be among the four leading causes of death globally (http://www.who.int/whosis/whostat2007_10highlights.pdf). According to WHO estimates, 210 million people currently have COPD, more than 3 million people died of COPD in 2005, corresponding to 5% of all deaths globally, and almost 90% of COPD deaths occur in LMICs (http://www.who.int/mediacentre/factsheets/fs315/en/) <http://www.who.int/mediacentre/factsheets/fs315/en/> . Obesity is becoming a major component of the healthcare landscape in developing countries, even in countries where under nutrition is simultaneously present sometime even in the same family. According to WHO, 2.3 billion adults (age ™ 15 years) will be overweight and 700 million will be obese worldwide by 2015. In 2005, over 20 million children (< 5 years) were overweight globally. Overweight and obesity are risk factors for many chronic diseases that affect the quality of life and lead to premature mortality. Obesity, can for example, lead to hypertension, Type II diabetes, osteoarthritis, stroke, gall bladder disease, cancer and coronary artery disease. Cancer is becoming more common, due at least in part to aging populations. More than 70% of all cancer deaths occur in LMICs, where resources available for prevention, diagnosis and treatment of cancer are limited or nonexistent. Based on projections, cancer deaths will continue to rise with an estimated 9 million people dying from cancer in 2015, and 11.4 million dying from cancer in 2030 (http://www.who.int/cancer/en/) <http://www.who.int/cancer/en/> . The bulk of factors that are responsible for onset of the chronic disease are so diverse that it is essential that those trained in these areas of research have broad understanding or work across disciplines that might include nutrition, business and the corporate sector, behavioral health, health law, economics, environmental health and urban planning. Most of the research training and research on chronic diseases has been conducted in HICs and it has seldom been multidisciplinary. This program is therefore intended to strengthen research capacity by developing a pipeline of scientists in LMICs who will conduct transdisciplinary and implementation research in this field. In order to develop the research capacity to carry out scientific research on these and other topics related to chronic, non-communicable diseases, the Fogarty International Center has developed this particular FOA for this research training program. * The objectives of the research training program for chronic non-communicable diseases are: 1) To train a cadre of experts who can assess the magnitude of diseases such as cancer, cerebrovascular disease including stroke, lung disease including chronic obstructive pulmonary disease (COPD), and obesity as well as genetics, environmental factors including indoor air pollution, and lifestyle factors related to these conditions in LMICs; 2) To support training-related research projects (degree-related or mentored research) that address issues of importance to chronic disease, directly relevant to the needs of the people in the foreign country, and are culturally sensitive; 3) To strengthen the research training capacity and institutional infrastructure required for success by building on existing research programs on chronic diseases at the foreign sites; 4) To develop methods to monitor and understand the etiology of chronic non-communicable disease; 5) To train researchers who perform research in chronic non-communicable diseases across a broad range of research areas from genetics to epidemiology to clinical research to implementation science; 6) To train researchers who can identify economic factors that influence chronic disease risks, and who can develop evidence regarding the impact of chronic non-communicable diseases on families and communities; and 7) To train individuals who can translate research into public health policy and into programs of care. ************************ Kathleen Michels, Ph.D Program Director -Neuroscience Cluster Division of International Training and Research Fogarty International Center, NIH Building 31 Rm B2C39, Bethesda, MD 20892 Ph: 301-435-6031, fax: 301-402-0779 [log in to unmask] FIC home page: http://www.fic.nih.gov/ **************************** ALERT! - Are you ready for electronic submission? Find out at: http://www.fic.nih.gov/funding/grants_info/index.htm and http://era.nih.gov/ElectronicReceipt/preparing_grantsgov_reg.htm To do business with the NIH, applicants MUST register with BOTH Grants.gov (www.grants.gov) AND the NIH eRA Commons https://commons.era.nih.gov/commons. * ALL FAQs on electronic submission: http://era.nih.gov/ElectronicReceipt/faq.htm# * For problems with the mechanics of submission- [log in to unmask] * For problems with the content of the submission- [log in to unmask] * Link to description of the warning and error messages for 424 http://era.nih.gov/ElectronicReceipt/files/SF424RR_Validations.pdf . * FOR NIH eRA Commons errors and resolutions: http://era.nih.gov/ElectronicReceipt/tips_tools.htm . Use e-mail support at: [log in to unmask] Please note: e-applications containing foreign subawards must list a DUNS number for the foreign institution. Here is where to get a DUNS number <http://fedgov.dnb.com/webform/displayHomePage.do;jsessionid=B9E740A165AEF672D17B1356675EED40> : You will find newly released instructions for foreign institution e-registration at http://era.nih.gov/ElectronicReceipt/preparing_grantsgov_reg.htm THE CHALLENGE One billion of the people alive today enjoy a long and healthy life. The challenge is to find ways to help the other five billion people live longer, healthier lives. - Paraphrased from Barry Bloom
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