National Toxicology Program

CASRN: 64-77-7

Formula: C12 H18 N2 O3 S

Synonyms/Common Names:

• N-((BUTYLAMINO)CARBONYL)-4-METHYLBENZENESULFONAMIDE (9CI)

Known Uses:

HYPOGLYCEMIC

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C01763) Completed 
  • NTIS No. PB274483  (Peer Review 09/26/1977)
    Citation: Bioassay of Tolbutamide for Possible Carcinogenicity (CAS No. 64-77-7)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C01763) Completed 
  • NTIS No. PB274483  (Peer Review 09/26/1977)
    Citation: Bioassay of Tolbutamide for Possible Carcinogenicity (CAS No. 64-77-7)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: MR: 0,300,6000, FR: 0,12000,24000, MM: 0,500,10000, FM: 0,20000,40000 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C01763) Report Complete 
  • TR-031 (NTIS No. PB274483)  (Peer Review 09/26/1977)
    Bioassay of Tolbutamide for Possible Carcinogenicity (CAS No. 64-77-7)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,12000,24000, M: 0,25000,50000 PPM/35 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (481185) Completed 
  • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (465250) Completed 
  •  Negative 
• Salmonella  (736579) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative