Concurrent Symposia Sessions

Tuesday, October 14, 2008
Natcher Conference Center
Symposia Session I
Balcony A

Hedgehog Signaling Pathway in Development & Disease	2:00 p.m. - 4:00 p.m.

Chair: Susan Mackem, NCI

Hedgehog (Hh) signaling controls many aspects of vertebrate embryonic development including organogenesis of many systems (CNS, cardiac, pulmonary, renal, GI, skeletal, dermal) and continues to regulate cell fate, differentiation and growth in many adult tissues. Recently, primary monocilia, present on virtually all cells, have been found to play a crucial role in Hh signal transduction. The Hh pathway has been implicated in the pathogenesis of many types of human disease, including various cancers, as well as genetic diseases and congenital malformations, and plays an important role in stem cell physiology.

Program

Uncoupling Shh Control of Pattern and Growth in the Developing Limb
Susan Mackem, NCI

A Syndrome Family Approach to Human Pleiotropic Malformations: GLI3 Phenotypes
Les Biesecker, NHGRI

Hedgehog Signaling Plays Critical Roles in Regulating Adult Bone and Cartilage Homeostasis
Yingzi Yang, NHGRI

A VACTERL Mutant Mouse Model Linking pcsk5 with Shh Signaling
Cecilia Lo, NHLBI

Hedgehog Signaling in Normal and Abnormal Brain Development in Humans
Max Muenke, NHGRI

Shh Signaling in Adult Neural Stem Cells
Sohyun Ahn, NICHD