DNA (cytosine-5-)-methyltransferase 1, Homo sapiens

Expression Profile:

View expression levels using UniGene's EST ProfileViewer
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Highly represented (2.5 pct) in cDNA library dbEST:5665, BT0616.

GEO profiles:

Gene expression profiles in the NCBI Gene Expression Omnibus database

cDNA Sources:

lymph node; brain; testis; uncharacterized tissue; mixed; embryonic tissue; placenta; uterus; intestine; mammary gland; blood; lymph; muscle; pancreas; thyroid; mouth; ear; adrenal gland; thymus; kidney; skin; stomach; lung; cervix; eye; liver; bladder; ascites; ovary; connective tissue; larynx; prostate; bone marrow; nerve; heart; bone; spleen; trachea; epididymis; pineal gland; vascular; pharynx

NCBI

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Finding cDNAs

UGID:162811 UniGene Hs.202672 Homo sapiens (human) DNMT1

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DNA (cytosine-5-)-methyltransferase 1 (DNMT1)

SELECTED PROTEIN SIMILARITIES

Comparison of sequences in UniGene with selected protein reference sequences. The alignments can suggest function of a gene.

Reference Protein		Species	Id(%)	Len(aa)
XP_850928.1	PREDICTED: similar to DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (DNA methyltransferase HsaI) (DNA MTase HsaI) (MCMT) (M.HsaI)	C. lupus familiaris	89.3	149

GENE EXPRESSION

Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.

MAPPING POSITION

Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.

	Chromosome:	19
	Map position:	19p13.2

SEQUENCES

Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (13)

AK122759.1	Homo sapiens cDNA FLJ16293 fis, clone OCBBF2021518, highly similar to DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37)	P
NM_001379.2	Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 2, mRNA	A
CR623729.1	full-length cDNA clone CS0DK010YJ22 of HeLa cells Cot 25-normalized of Homo sapiens (human)	P
CR610482.1	full-length cDNA clone CS0DI082YK14 of Placenta Cot 25-normalized of Homo sapiens (human)	P
CR607451.1	full-length cDNA clone CS0DC001YN24 of Neuroblastoma Cot 25-normalized of Homo sapiens (human)	P
CR598167.1	full-length cDNA clone CS0DI012YG19 of Placenta Cot 25-normalized of Homo sapiens (human)	P
CR594546.1	full-length cDNA clone CS0DA004YD07 of Neuroblastoma of Homo sapiens (human)	P
AF180682.1	Homo sapiens DNA (cytosine-5)-methyltransferase mRNA, complete cds	PA
AY927518.1	Homo sapiens mRNA sequence
AB209413.1	Homo sapiens mRNA for DNA (cytosine-5-)-methyltransferase 1 variant protein	P
BC126227.1	Homo sapiens DNA (cytosine-5-)-methyltransferase 1, mRNA (cDNA clone MGC:161505 IMAGE:8991943), complete cds
X63692.1	H.sapiens mRNA for DNA (cytosin-5)-methyltransferase	PA
NM_001130823.1	Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 1, mRNA	A

EST sequences (10 of 583) [Show all sequences]

R17473.1	Clone IMAGE:32332	brain	5' read
AI003012.1	Clone IMAGE:1683909	brain	3' read
AI003132.1	Clone IMAGE:1700009	kidney	3' read
AI003705.1	Clone IMAGE:392109	pineal gland	3' read	A
AI033322.1	Clone IMAGE:1655125	mixed	3' read	A
AI078013.1	Clone IMAGE:1674424	mixed	3' read	A
AI141776.1	Clone IMAGE:1690752	mixed	3' read	A
BX109812.1	Clone IMAGp998O18272_;_IMAGE:45941	brain
AI174310.1	Clone IMAGE:1577121	spleen	3' read
AI188287.1	Clone IMAGE:1723052	placenta	3' read	A

Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria