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Translocation

Definition(s)

A chromosome alteration in which a whole chromosome or segment of a chromosome becomes attached to or interchanged with another whole chromosome or segment, the resulting hybrid segregating together at meiosis; balanced translocations (in which there is no net loss or gain of chromosome material) are usually not associated with phenotypic abnormalities, although gene disruptions at the breakpoints of the translocation can, in some cases, cause adverse effects, including some known genetic disorders; unbalanced translocations (in which there is loss or gain of chromosome material) nearly always yield an abnormal phenotype: Definition from: GeneTests from the University of Washington and Children's Health System, Seattle
Breakage and removal of a large segment of DNA from one chromosome, followed by the segment's attachment to a different chromosome.: Definition from: Talking Glossary of Genetic Terms from the National Human Genome Research Institute
A mutation in which a large segment of one chromosome breaks off and attaches to another chromosome.: Definition from: Human Genome Project Information at the U.S. Department of Energy


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