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Sponsored by: |
National Institute of Mental Health (NIMH) |
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Information provided by: | National Institute of Mental Health (NIMH) |
ClinicalTrials.gov Identifier: | NCT00006418 |
This study will create a DNA collection with blood samples from families with at least two siblings who have schizophrenia symptoms. This collection will help scientists identify genes that predispose people to schizophrenia.
Condition | Intervention |
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Schizophrenia |
Procedure: DNA collection |
Study Type: | Observational |
Study Design: | Natural History |
Estimated Enrollment: | 10800 |
Study Start Date: | September 2003 |
Estimated Study Completion Date: | August 2007 |
Each site will recruit individuals in a large geographic area, and use efficient ascertainment strategies and assessment procedures in order to maximize the number collected. Subjects thought to have schizophrenia will be assessed by personal and family interviews and a review of medical records. Diagnoses will be made by consensus best-estimate procedures. Blood specimens will be obtained from all individuals with schizophrenia or schizoaffective disorder plus their available parents and also the control individuals. A clinical self-assessment will be administered to each control subject. The assessment will include validated self-assessments of lifetime major depression, anxiety disorders, and substance use, and self-reported history of bipolar or psychotic symptoms. Permanent cell lines will be created and DNA extracted at the NIMH-sponsored Center for Genetic Studies. At the end of the four-year project period, biological materials and blinded pedigree and clinical data will be made available to the scientific community for genetic studies of schizophrenia and related disorders. The control sample will, however, be released in a staggered fashion, twice during each fiscal year, to start during the 2nd year of recruitment. The informed consent for controls includes consent for specimens to be used in research on the genetics of any medical disorder. In years 3 and 4, we will undertake association analyses. Power analyses suggest that this study will have excellent power to detect loci associated with genes with relatively small etiologic effects. Data derived from this study will potentially have applications for the treatment and prevention of schizophrenia.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, California | |
University of California, Irvine | Recruiting |
Irvine, California, United States, 92697 | |
Contact: Sentelle Eubanks 877-259-4355 seubanks@uci.edu | |
Principal Investigator: William Byerley, MD | |
United States, Colorado | |
University of Colorado Health Sciences Center | Recruiting |
Denver, Colorado, United States, 80262 | |
Contact: Ann Olincy, MD 303-315-5046 ann.olincy@uchsc.edu | |
Principal Investigator: Robert Freedman, MD | |
United States, Georgia | |
Emory University | Recruiting |
Atlanta, Georgia, United States, 30322 | |
Contact: Susan Green, MPH 404-321-6111 sygree2@emory.edu | |
Principal Investigator: Farooq Amin, MD | |
United States, Illinois | |
Evanston Northwestern Healthcare Research Institute | Recruiting |
Evanston, Illinois, United States, 60201 | |
Contact: Katie Gutrich, MEd, BSN, RN 866-636-8228 kgutrich@enh.org | |
Principal Investigator: Pablo V. Gejman, MD | |
United States, Iowa | |
University of Iowa College of Medicine | Recruiting |
Iowa City, Iowa, United States, 52242 | |
Contact: Jessica Deaderick, BA 800-777-8442 jessica-deaderick@uiowa.edu | |
Principal Investigator: Raymond R. Crowe, MD | |
United States, Louisiana | |
Louisiana State University Health Sciences Center | Recruiting |
New Orleans, Louisiana, United States, 70112 | |
Contact: Nancy G. Buccola, APRN, BA, MSN 504-568-4194 nbucco@lsuhsc.edu | |
Principal Investigator: Nancy G. Buccola, APRN, BC, MSN | |
United States, Missouri | |
Washington University School of Medicine | Recruiting |
St. Louis, Missouri, United States, 63128 | |
Contact: Art Schaffer, MA 888-925-7252 schaffer@tci.wustl.edu | |
Principal Investigator: Robert Cloninger, MD | |
United States, New York | |
Mount Sinai School of Medicine | Recruiting |
New York, New York, United States, 10029 | |
Contact: Brandon Yanowitz 212-659-5619 Brandon.Yanowitz@mssm.edu | |
Principal Investigator: Jeremy M. Silverman, PhD | |
United States, Pennsylvania | |
University of Pennsylvania School of Medicine | Recruiting |
Philadelphia, Pennsylvania, United States, 19104 | |
Contact: Tony Zapisek, RN 877-407-9529 zapisek@mail.med.upenn.edu | |
Principal Investigator: Douglas F. Levinson, MD | |
Australia, Queensland | |
University of Queensland | Recruiting |
Brisbane, Queensland, Australia, 4029 | |
Contact: Deborah Nertney, BSc 1-800-682-699 deb_nertney@qcsr.uq.edu.au | |
Principal Investigator: Brian J. Mowry, MD |
Study ID Numbers: | R01 MH59571, R01 MH59571, R01 MH59588, R01 MH60870, R01 MH59565, R01 MH59566, R01 MH60879, R01 MH59586, R01 MH61675, R01 MH59587, DNBBS 7G-GRR |
Study First Received: | October 25, 2000 |
Last Updated: | November 18, 2005 |
ClinicalTrials.gov Identifier: | NCT00006418 |
Health Authority: | United States: Federal Government |
Schizophrenia Genetics |
Schizophrenia Mental Disorders Psychotic Disorders Schizophrenia and Disorders with Psychotic Features |