Summaries & Associations of Study Results
Levels from TR-529 2,2',4,4',5,5',-Hexachlorobiphenyl
Target Organs and Levels of Evidence
NTP Technical Report Number 529
Produced from Chemtrack Database 05/19/05
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153- 2,2'-4,4',5,5'- HEXACHLOROBIPHENYL) 35065-27-1 |
12/09/04 | Gavage FEMALE RATS ONLY: PCB-153 - 0, 10, 100, 300, 1000, OR 3000 UG/KG AND 3000 UG/KG (STOP-EXPOSURE); 50/DOSE | Battelle Columbus Laboratory | |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| FR: EQUIVOCAL EVIDENCE | LIVER: CHOLANGIOMA 0/53 0/54 0/53 0/53 2/53 0/51 2/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: HEPATOCYTE HYPERTROPHY; DIFFUSE FATTY CHANGE; BILE DUCT HYPERPLASIA; OVAL CELL HYPERPLASIA; PIGMENTATION | |||
| THYROID GLAND: FOLLICULAR CELL HYPERTROPHY | ||||
| OVARY: CHRONIC ACTIVE INFLAMMATION | ||||
| OVIDUCT: CHRONIC ACTIVE INFLAMMATION | ||||
| UTERUS: SUPPURATIVE INFLAMMATION; CHRONIC ACTIVE INFLAMMATION | ||||
Web page last updated on October 25, 2007
