Edmund Rucker : NIDDK

Scientific Programs

Edmund Rucker

Dr. Edmund Rucker joined our laboratory in 1996 to explore the role of the bcl-x gene in mammary gland development and remodelling through a mammary specific deletion of the gene in the mouse. Ed targeted the mouse bcl-x gene with loxP sites, which permitted him to inactivate it in different cell types. As part of this project he generated a Bcl-x hypomorph, which led to the discovery that Bcl-x is critical for male and female germ cell survival. Ed also dicovered that Bax is the counterpart to Bcl-x in germ cells.

Ed left in February 2000 to take on a faculty position at the University of Missouri. Rucker lab

Publications while in LGP

PubMed search

2. Hon, H., Rucker, E.B., Hennighausen, L. and Jacob, J. (2004) Bcl-x is critical for dentritic cell survival in vivo. J. Immunol. 2004, 173, 4425-4432.

3. Wagner, K.U., Krempler, A., Qi, Y., Park, K., Henry, M.D., Triplett, A.A., Riedlinger, G., Rucker, E.B. and Hennighausen, L. (2003) TSG101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissue, Mol. Cell. Biol., 23, 150-162.

4. Riedlinger, G., Okagaki, R., Wagner, K.U., Rucker, E.B., Oka, T., Miyoshi, K., Flaws, J.A. and Hennighausen, L. (2002) Bcl-x is not required for the maintenance of follicles and the corpus luteum in the postnatal mouse ovary. Biology of Reproduction, 66, 438-444.

5. Walton, K.D., Wagner, K.-U., Rucker, E.B., Shillingford, J.M., Miyoshi, K. and Hennighausen, L. (2001) Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation. Mech. of Development 109, 281-293.

6. Wagner, K-U., Estefania C., Rucker, E.B., Riedlinger, G, Broussard, C., Schwartzberg, P.L., Siebenlist, U., Hennighausen, L. (2000) Conditional deletion of the bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development, 127, 4949-4958.

7. Rucker, E.B., Dierisseau, P., Wagner, K.-U., Garrett, L., Wynshaw-Boris, A., Flaws, J. and Hennighausen, L., (2000). Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol. Endo., 7, 1038-1052.

8. Wagner, K.-U., Dierisseau, P., Rucker, III, E.B., Robinson, G.W. and Hennighausen, L. (1998). Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: Common types of shorter transcripts are true alternative splice variants. Oncogene, 17, 2761-2770.

9. Wagner, K.-U., Rucker, E.B. and Hennighausen, L. (2000) Targeting genes in the mammary epithelium. In: Methods in Mammary Gland Biology and Breast Research. M.M. Ip and B.B. Ash (ed.) Kluwer Academic / Plenum Publishers. pp .

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