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Paul F. Morrison, Ph.D.
Physical Scientist/Special Volunteer
Drug Delivery and Kinetics
Laboratory of Bioengineering and Physical Science
Bldg. 13, Rm. 3W 10A
Tel: 301-435-1959 (Direct), 301-496-4426 (Program office)
Fax: 301-496-6608
E-mail: morrison@mail.nih.gov
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Research Expertise and Interest
- Development and analysis of direct interstitial infusion of agents to the central nervous system
- Biological application of mass and fluid transfer including finite element techniques accounting for anatomical boundaries and anisotropies
- Population dynamics of extrachromosomal elements including double minutes and plasmids
- Distributed and compartmental pharmacokinetics; quantitative microdialysis
Selected Publications
- Croteau D, Walbridge S, Morrison PF, Butman JA, Vortmeyer AO, Johnson D, Oldfield EH, Lonser RR.. Real-time, in vivo, computed tomographic imaging of convection-enhanced delivery of a low molecular weight tracer. J Neurosurgery, 102: 90-97, 2005.
- Morrison PF, Chattoraj DK. Replication of a unit-copy plasmid F in the bacterial cell cycle: A replication rate function analysis. Plasmid, 52: 15-30, 2004. (MorrPlasmid_2004.pdf (Adobe PDF 294K)
- Sarntinoranont M, Iadarola MJ, Morrison PF. A kinetic analysis of substance P trafficking. J Pharm Sci, 92: 232-243, 2003.
- Sarntinoranont M, Iadarola MJ, Lonser RR, Morrison PF. Direct interstitial infusion of NK1 targeted neurotoxin into the spinal cord: A computational model. Am J Physiol, 285: R243-R254, 2003. (SarntiMorrAJP_2003.pdf (Adobe PDF 535 K)
- Morrison PF, Chen MY, Chadwick RS, Lonser RR, Oldfield EH. Focal delivery during direct infusion to brain: Role of flow rate, catheter diameter, and tissue mechanics. Am J Physiol, 277: R1218-R1229, 1999.
- Beagles KE, Morrison PF, Heyes MP. Quinolinic acid in vivo synthesis rates, extracellular concentrations, and intercompartmental distributions in normal and immune activated brain as determined by multiple isotope microdialysis. J Neurochem, 70: 281-291, 1998.
Patents
- Convection-Enhanced Drug Delivery. United States Patent 5,720,720. Laske DW, Oldfield EH, Bobo RH, Dedrick RL, Morrison PF. Awarded February 24, 1998.
Books
- Morrison PF. Distributed models of drug kinetics. In: Atkinson A., Daniels CE, Dedrick RL, Grudzinskas CV, Markey SP, eds., Principles of Clinical Pharmacology. New York: Academic Press, 93-112, 2001.
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