Appendix Table 2. Data Used in the Analysisa

Study: CNBSS

Ref Age Mean FU Intervention Group: Deaths Intervention Group: Subjects Intervention Group: Life-years Intervention Group: Rate/10,000 Control Group: Deaths Control Group: Subjects Control Group: Life-years Control Group: Rate/10,000 95% CI: RR 95% CI: Lower 95% CI: Upper
Miller, unpublished manuscript 40-49 13.0 105 25,214 282,606 3.7 108 25,216 282,575 3.8 0.97 0.74 1.27
Miller et al, 199721,b 40-49 10.5 82 25,214 264,747 3.1 72 25,216 264,768 2.7 1.14 0.83 1.56
Miller et al, 199212 40-49 8.5 38 25,214 214,319 1.8 28 25,216 214,336 1.3 1.36 0.84 2.21
40-59 13.0 212 44,925 584,025 3.6 213 44,910 583,830 3.6 1.00 0.82 1.20
40-59 8.5 76 44,925 381,863 2.0 67 44,910 381,735 1.8 1.13 0.82 1.57
Miller et al, 200020 50-59 13.0 107 19,711 216,133 5.0 105 19,694 216,042 4.9 1.02 0.78 1.33
Miller et al, 199213 50-59 8.3 38 19,711 163,601 2.3 39 19,694 163,460 2.4 0.97 0.62 1.52

Study: HIP

Ref Age Mean FU Intervention Group: Deaths Intervention Group: Subjects Intervention Group: Life-years Intervention Group: Rate/10,000 Control Group: Deaths Control Group: Subjects Control Group: Life-years Control Group: Rate/10,000 95% CI: RR 95% CI: Lower 95% CI: Upper
Shapiro, 199727,b 40-49 18.0 49 13,740 247,320 2.0 65 13,740 247,320 2.6 0.75 0.52 1.09
Habbema et al, 1986122 40-49 14.0 64 13,740 192,360 3.3 82 13,740 192,360 4.3 0.78 0.56 1.08
Shapiro et al, 198819 40-49 10.0 39 13,740 137,400 2.8 51 13,740 137,400 3.7 0.76 0.50 1.16
Shapiro et al, 198819 40-49 5.0 19 13,740 68,700 2.8 20 13,740 68,700 2.9 0.95 0.51 1.78
Shapiro et al, 198819 40-64 18.0 126 30,245 544,410 2.3 163 30,245 544,410 3.0 0.77 0.61 0.98
Shapiro et al, 1985123 40-64 16.0 236 30,239 483,824 4.9 281 30,756 492,096 5.7 0.85 0.72 1.02
Habbema et al, 1986122 40-64 14.0 165 30,245 423,430 3.9 212 30,245 423,430 5.0 0.78 0.64 0.95
Shapiro et al, 198819 40-64 10.0 95 30,245 302,450 3.1 133 30,245 302,450 4.4 0.71 0.55 0.93
Shapiro et al, 198819 40-64 5.0 39 30,245 151,225 2.6 63 30,245 151,225 4.2 0.62 0.42 0.92
Shapiro et al, 198819 50-64 18.0 77 16,505 297,090 2.6 98 16,505 297,090 3.3 0.79 0.58 1.06
Habbema et al, 1986122 50-64 14.0 101 16,505 231,070 4.4 130 16,505 231,070 5.6 0.78 0.60 1.01
Shapiro et al, 198819 50-64 10.0 56 16,505 165,050 3.4 82 16,505 165,050 5.0 0.68 0.49 0.96
Shapiro et al, 198819 50-64 5.0 20 16,505 82,525 2.4 43 16,505 82,525 5.2 0.47 0.27 0.79

Study: Gothenburg

Ref Age Mean FU Intervention Group: Deaths Intervention Group: Subjects Intervention Group: Life-years Intervention Group: Rate/10,000 Control Group: Deaths Control Group: Subjects Control Group: Life-years Control Group: Rate/10,000 95% CI: RR 95% CI: Lower 95% CI: Upper
Bjurstam et al, 199724,b 39-49 11.8 18 11,724 138,402 1.3 40 14,217 168,025 2.4 0.55 0.31 0.96
Nystrom et al, 200223 40-49 12.7 22 10,888 138,000 1.6 46 13,203 167,000 2.8 0.58 0.35 0.96
Larsson et al, 199750 40-49 9.8 16 10,821 106,000 1.5 33 13,101 129,000 2.6 0.59 0.33 1.06
Nystrom et al, 200223 40-59 12.8 62 21,000 268,000 2.3 113 29,200 373,000 3.0 0.76 0.56 1.04
Nystrom et al, 199332 40-59 6.3 27 20,724 129,000 2.1 47 28,809 181,000 2.6 0.86 0.54 1.37
Nystrom et al, 200223 50-59 12.9 40 10,112 130,000 3.1 67 15,997 206,000 3.3 0.94 0.62 1.43

Study: Stockholm

Ref Age Mean FU Intervention Group: Deaths Intervention Group: Subjects Intervention Group: Life-years Intervention Group: Rate/10,000 Control Group: Deaths Control Group: Subjects Control Group: Life-years Control Group: Rate/10,000 95% CI: RR 95% CI: Lower 95% CI: Upper
Nystrom et al, 200223 40-49 14.3 34 14,303 203,000 1.7 13 8,021 117,000 1.1 1.52 0.80 2.88
Frisell and Lidbrink, 1997124,b 40-49 11.9 24 14,842 173,866 1.4 12 7,103 87,826 1.4 1.08 0.54 2.17
Larsson et al, 199750 40-49 11.5 23 14,185 162,000 1.4 10 7,985 94,000 1.1 1.34 0.64 2.80
Frisell et al, 1991125 40-49 7.2 16 14,375 99,155 1.6 8 7,103 54,446 1.5 1.09 0.40 3.00
Frisell et al, 199717 40-64 11.8 66 40,318 473,153 1.4 45 19,943 239,460 1.9 0.74 0.50 1.10
Frisell et al, 1991125 40-64 7.1 39 39,164 270,247 1.4 30 19,943 147,373 2.0 0.71 0.40 1.20
Nystrom et al, 200223 40-65 13.8 82 39,139 535,000 1.5 50 20,978 296,000 1.7 0.91 0.65 1.27
Nystrom et al, 199332 40-65 7.6 53 38,525 287,000 1.8 40 20,651 164,000 2.4 0.80 0.53 1.22
Nystrom et al, 200223 50-59 13.7 25 15,946 217,000 1.2 24 8,421 118,000 2.0 0.56 0.32 0.97
Frisell et al, 199717 50-64 11.8 42 25,476 299,287 1.4 33 12,840 151,634 2.2 0.62 0.38 1.00
Frisell et al, 1991125 50-64 7.0 23 24,789 171,092 1.3 22 12,840 92,927 2.4 0.57 0.30 1.10

Study: Malmö I + II

Ref Age Mean FU Intervention Group: Deaths Intervention Group: Subjects Intervention Group: Life-years Intervention Group: Rate/10,000 Control Group: Deaths Control Group: Subjects Control Group: Life-years Control Group: Rate/10,000 95% CI: RR 95% CI: Lower 95% CI: Upper
Nystrom et al, 200223 43-49 13.3 53 13,568 184,000 2.9 66 12,279 160,000 4.1 0.73 0.51 1.04
Andersson and Janzon, 199715,b 43-49 12.0 57 13,528 165,596 3.4 78 12,242 144,036 5.4 0.64 0.45 0.89
Nystrom et al, 200223 43-70 15.3 190 30,669 473,000 4.0 231 29,407 448,000 5.2 0.79 0.65 0.96
Nystrom et al, 200223 45-49 18.0 24 3,987 71,000 3.4 33 4,067 74,000 4.5 0.74 0.44 1.25
Larsson et al, 199750 45-49 15.4 15 3,945 61,000 2.5 23 4,017 62,000 3.7 0.67 0.35 1.27
Nystrom et al, 200223 45-54 18.2 71 8,673 158,000 4.5 78 8,311 151,000 5.2 0.87 0.63 1.20
Andersson et al, 198825 45-54 9.0 28 7,981 71,775 3.9 22 8,082 72,635 3.0 1.29 0.74 2.25
Andersson et al, 198825 45-69 8.8 63 21,088 186,297 3.4 66 21,195 187,016 3.5 0.96 0.68 1.35
Nystrom et al, 200223 45-70 17.1 161 21,088 360,000 4.5 198 21,195 362,000 5.5 0.82 0.67 1.00
Nystrom et al, 199332 45-70 11.5 87 20,695 239,000 3.6 108 20,783 240,000 4.5 0.81 0.62 1.07
Nystrom et al, 200223 50-70 16.9 137 17,101 289,000 4.7 165 17,128 288,000 5.7 0.83 0.66 1.04
Nystrom et al, 200223 55-64 17.2 63 8,194 141,000 4.5 83 8,679 149,000 5.6 0.80 0.57 1.12
Andersson et al, 198825 55-69 8.7 35 13,107 114,522 3.1 44 13,113 114,381 3.8 0.79 0.51 1.24
Nystrom et al, 200223 55-70 16.3 90 12,415 202,000 4.5 120 12,884 211,000 5.7 0.78 0.59 1.02

Study: 2-county, Kopparberg

Ref Age Mean FU Intervention Group: Deaths Intervention Group: Subjects Intervention Group: Life-years Intervention Group: Rate/10,000 Control Group: Deaths Control Group: Subjects Control Group: Life-years Control Group: Rate/10,000 95% CI: RR 95% CI: Lower 95% CI: Upper
Tabár et al, 200026 40-49 17.3 NR NR NR NR NR NR NR NR 0.76 0.42 1.40
Tabár et al, 199516 40-49 13.0 22 9,582 124,566 1.8 16 5,031 65,403 2.4 0.73 0.37 1.41
Tabár et al, 198928 40-49 7.9 13 9,582 75,698 1.7 9 5,031 39,745 2.3 0.76 0.32 1.77
Tabár et al, 198535 40-49 6.0 8 9,625 57,750 1.4 3 5,053 30,318 1.0 1.40 0.37 5.28
Tabár et al, 200026 40-74 17.3 152 NR 672,482 2.3 121 NR 326,091 3.7 0.61 NR NR
Tabár et al, 199516 40-74 13.0 126 38,589 501,657 2.5 104 18,582 241,566 4.3 0.60 0.46 0.79
Tabár et al, 198928 40-74 7.9 77 38,589 304,853 2.5 58 18,582 146,798 4.0 0.64 0.46 0.90
Tabár et al, 198535 40-74 6.0 51 39,051 234,306 2.2 39 18,846 113,076 3.4 0.63 0.42 0.96
Tabár et al, 200026 50-59 17.3 NR NR NR NR NR NR NR NR 0.46 0.30 0.71
Tabár et al, 199516 50-59 13.0 34 11,728 152,464 2.2 34 5,557 72,241 4.7 0.48 0.29 0.77
Tabár et al, 198928 50-59 7.9 20 9,582 75,698 2.6 20 5,031 39,745 5.0 0.53 0.28 0.98
Tabár et al, 199516 50-74 13.0 104 29,007 377,091 2.8 88 13,551 176,163 5.0 0.58 0.43 0.78
Tabár et al, 198928 50-74 7.9 64 29,007 229,155 2.8 49 13,551 107,053 4.6 0.61 0.42 0.89
Tabár et al, 198535 50-74 6.0 43 29,426 176,556 2.4 36 13,793 82,758 4.4 0.56 0.36 0.87

Study: 2-county, Östergötland

Ref Age Mean FU Intervention Group: Deaths Intervention Group: Subjects Intervention Group: Life-years Intervention Group: Rate/10,000 Control Group: Deaths Control Group: Subjects Control Group: Life-years Control Group: Rate/10,000 95% CI: RR 95% CI: Lower 95% CI: Upper
Tabár et al, 200026 40-49 17.3 NR NR NR NR NR NR NR NR 1.06 0.65 1.76
Nystrom et al, 200223 40-49 16.8 31 10,285 172,000 1.8 30 10,459 176,000 1.7 1.05 0.64 1.71
Tabár et al, 199516 40-49 13.0 23 10,262 133,406 1.7 23 10,573 137,449 1.7 1.02 0.52 1.99
Tabár et al, 198928 40-49 7.9 15 10,262 81,070 1.9 15 10,573 83,527 1.8 1.03 0.50 2.11
Tabár et al, 198535 40-49 6.0 8 10,312 61,872 1.3 7 10,625 63,750 1.1 1.18 0.43 3.25
Tabár et al, 200026 40-74 17.3 167 NR 660,242 2.5 213 NR 643,696 3.3 0.76 NR NR
Nystrom et al, 200223 40-74 15.2 177 38,942 589,000 3.0 190 37,675 572,000 3.3 0.90 0.73 1.11
Tabár et al, 199516 40-74 13.0 135 38,491 500,383 2.7 173 37,403 486,239 3.6 0.78 0.60 1.01
Tabár et al, 198928 40-74 7.9 83 38,491 304,079 2.7 109 37,403 295,484 3.7 0.74 0.56 0.98
Tabár et al, 198535 40-74 6.0 36 39,034 234,204 1.5 47 37,936 227,616 2.1 0.74 0.48 1.15
Tabár et al, 200026 50-59 17.3 NR NR NR NR NR NR NR NR 0.76 0.53 1.10
Nystrom et al, 200223 50-59 16.1 53 12,011 194,000 2.7 54 11,495 185,000 2.9 0.94 0.66 1.35
Tabár et al, 199516 50-59 13.0 44 11,757 152,841 2.9 51 11,248 146,224 3.5 0.85 0.52 1.38
Tabár et al, 198928 50-59 7.9 25 11,757 92,880 2.7 34 11,248 88,859 3.8 0.70 0.42 1.18
Nystrom et al, 200223 50-74 14.9 146 28,657 417,000 3.5 160 25,920 396,000 4.0 0.83 0.66 1.03
Tabár et al, 199516 50-74 13.0 112 28,229 366,977 3.1 150 26,830 348,790 4.3 0.73 0.56 0.97
Tabár et al, 198928 50-74 7.9 68 28,229 223,009 3.0 94 26,830 211,957 4.4 0.69 0.50 0.94
Tabár et al, 198535 50-74 6.0 28 28,722 172,332 1.6 40 27,311 163,866 2.4 0.67 0.41 1.08

Study: Kopparberg + Östergötland

Ref Age Mean FU Intervention Group: Deaths Intervention Group: Subjects Intervention Group: Life-years Intervention Group: Rate/10,000 Control Group: Deaths Control Group: Subjects Control Group: Life-years Control Group: Rate/10,000 95% CI: RR 95% CI: Lower 95% CI: Upper
Tabár et al, 199516 40-49 13.0 45 19,844 257,972 1.7 39 15,604 202,852 1.9 0.87 0.54 1.41
Tabár et al, 198928 40-49 7.9 28 19,844 156,768 1.8 24 15,604 123,272 1.9 0.92 0.52 1.60
Tabár et al, 198928 40-49 7.9 28 19,844 156,768 1.8 24 15,604 123,272 1.9 0.92 0.53 1.58
Tabár et al, 198535 40-49 6.0 16 19,937 119,622 1.3 10 15,678 94,068 1.1 1.26 0.56 2.84
Tabár et al, 200026 40-74 17.3 319 77,080 1,332,724 2.4 334 55,985 969,787 3.4 0.68 0.59 0.80
Tabár et al, 199516 40-74 12.5 269 77,080 965,405 2.8 277 55,985 701,207 4.0 0.69 0.57 0.84
Tabár et al, 198928 40-74 7.9 160 77,080 608,932 2.6 167 55,985 442,282 3.8 0.70 0.56 0.86
Tabár et al, 198535 40-74 6.0 87 78,085 468,510 1.9 86 56,782 340,692 2.5 0.69 0.51 0.92
Tabár et al, 199516 50-59 13.0 78 23,485 305,305 2.6 85 16,805 218,465 3.9 0.66 0.46 0.93
Tabár et al, 198928 50-59 7.9 45 23,485 185,532 2.4 54 16,805 132,760 4.1 0.60 0.40 0.89
Tabár et al, 199516 50-74 13.0 224 57,236 744,068 3.0 238 55,985 727,805 3.3 0.66 0.54 0.81
Tabár et al, 198928 50-74 7.9 132 57,236 452,164 2.9 143 40,381 319,010 4.5 0.65 0.51 0.83
Tabár et al, 198535 50-74 6.0 71 58,148 348,888 2.0 76 41,104 246,624 3.1 0.61 0.44 0.84

Study: Edinburgh

Ref Age Mean FU Intervention Group: Deaths Intervention Group: Subjects Intervention Group: Life-years Intervention Group: Rate/10,000 Control Group: Deaths Control Group: Subjects Control Group: Life-years Control Group: Rate/10,000 95% CI: RR 95% CI: Lower 95% CI: Upper
Alexander et al, 199918 45-49 12.2 47 11,479 139,868 3.4 53 10,267 126,413 4.2 0.75 0.48 1.18
Alexander, 1997126,b 45-49 12.2 46 NR 139,871 3.3 52 NR 126,417 4.1 0.88 0.55 1.41
Alexander et al, 1994127 45-49 8.5 25 11,505 97,206 2.6 31 10,269 88,766 3.5 0.78 0.46 1.31
Roberts et al, 1990128 45-49 6.9 13 5,913 40,851 3.2 13 5,810 40,009 3.2 0.98 NR NR
Alexander et al, 199918 45-64 13.0 156 22,926 301,155 5.2 167 21,342 276,363 6.0 0.79 0.60 1.02
Alexander et al, 1994127 45-64 9.5 96 22,944 219,215 4.4 106 21,344 201,821 5.3 0.82 0.61 1.11
Roberts et al, 1990128 45-64 6.8 68 23,226 157,946 4.3 76 21,904 147,854 5.1 0.83 0.58 1.18
Alexander et al, 199918 50-64 12.9 129 17,149 222,393 5.8 134 15,748 200,637 6.7 0.87 NR NR
Alexander et al, 1994127 50-64 9.4 79 17,149 162,465 4.9 85 15,748 147,233 5.8 0.85 0.62 1.15
Roberts et al, 1990128 50-64 6.7 55 17,313 117,095 4.7 63 16,094 107,845 5.8 0.80 0.54 1.17

aNumbers in bold are calculated from data in the spreadsheet; all other numbers were taken from publications.
bUsed in reference 30.

Note: CI indicates confidence interval; CNBSS, Canadian National Breast Screening Study; FU, follow-up; HIP, Health Insurance Plan of greater New York; NR, not reported; RR, relative risk.

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