Testing Status of Agents at NTP
o-Anthranilic acid
CASRN: 118-92-3
Formula: C7 H7 N O2
Synonyms/Common Names:
- BENZOIC ACID, O-AMINO
Known Uses:
INTERMEDIATE IN DYE SYNTHESIS, VITAMINS, NECESSARY FOR LACTATION (MERCK 1989)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C01730) Completed
- NTIS No. PB278883
(Peer Review 11/28/1977)
Citation: Bioassay of Anthranilic Acid for Possible Carcinogenicity (CAS No. 118-92-3) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB278883
(Peer Review 11/28/1977)
- 13-Week (Dosed-Feed)
(C01730) Completed
- NTIS No. PB278883
(Peer Review 11/28/1977)
Citation: Bioassay of Anthranilic Acid for Possible Carcinogenicity (CAS No. 118-92-3) - Rats: F344/N; Mice: B6C3F1
- Dose: MR&MM: 0,1000,50000 PPM/5 PER GROUP
- NTIS No. PB278883
(Peer Review 11/28/1977)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C01730) Report Complete
- TR-036 (NTIS No. PB278883)
(Peer Review 11/28/1977)
Bioassay of Anthranilic Acid for Possible Carcinogenicity (CAS No. 118-92-3) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0,15000,30000, M: 0,25000,50000 PPM/35 PER GROUP
- TR-036 (NTIS No. PB278883)
(Peer Review 11/28/1977)
Genetic Toxicology
- Chromosome Aberrations
(919747) Completed
- Mice
- Chromosome Aberation Equivocal
- In Vitro Cytogenetics (CA/SCE)
(313261) Completed
- Chromosome Aberation Weakly Positive
- Sister Chromatid Exchange Positive
- Mouse Lymphoma (NCI)
(217797) Completed
- Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
- Mouse Lymphoma-NCI Positive
- Mouse Lymphoma (NCI)
(879005) Completed
- Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
- Mouse Lymphoma-NCI Positive
- Salmonella
(988097) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
- Negative
- Sister Chromatid Exchanges
(919747) Completed
- Mice
- Sister Chromatid Positive
Web page last updated on January 22, 2009