CGAP       the Cancer Genome Anatomy Project
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The CANCER GENOME ANATOMY PROJECT

The goal of the NCI's Cancer Genome Anatomy Project is to determine the gene expression profiles of normal, precancer, and cancer cells, leading eventually to improved detection, diagnosis, and treatment for the patient. By collaborating with scientists worldwide, CGAP seeks to increase its scientific expertise and expand its databases for the benefit of all cancer researchers.

The CGAP Web Site

Interconnected modules provide access to all CGAP data, bioinformatic analysis tools, and biological resources allowing the user to find "in silico" answers to biological questions in a fraction of the time it once took in the laboratory.
Genes Genes
Gene information, clone resources, SNP500Cancer, GAI, and transcriptome analysis
Chromosomes Chromosomes
FISH-mapped BAC clones, SNP500Cancer, and the Mitelman database of chromosome aberrations
Tissues Tissues
cDNA library information, methods, and EST-based gene expression analysis
SAGE SAGE Genie
Analysis of gene expression using long and short SAGE tag data for both human and mouse
Pathways Pathways
Diagrams of biological pathways and protein complexes, with links to genetic resources for each known protein
Tools Tools
Direct access to all analytic and data mining tools developed for the project
RNAi RNAiNew
RNA-interference constructs, targeted specifically against cancer relevant genes. New addition: Validated set of shRNAs targeted to cancer genes.

New Initiatives

  • The NCI supports the Initiative for Chemical Genetics (ICG), which is developing a systematic approach for harnessing synthetic chemistry to discover molecular mechanisms in basic cell biology. This approach aims to emulate the success of classical genetics as a discovery platform using chemicals that alter the function of specific proteins in place of mutations. These results will be incorporated into the Gene Info pages of the relevant genes.
  • The OCG/NCI and NHGRI recently convened a workshop to assess the value of a project to catalogue all of the DNA sequence changes that occur in tumorigenesis. A summary of the workshop and its recommendations are available at Exploring Cancer through Genomic Sequence Comparisons. Follow-up information will be posted on the CGAP web site as it becomes available.
  • In July 2005, the NCI and NHGRI convened a workshop in Washington, DC entitled “Toward a Comprehensive Genomic Analysis of Cancer?. This meeting brought together physicians, basic scientists, and other members of the U.S. and international cancer communities to assist in outlining the most effective strategies for the development of a successful pilot phase of the human cancer genome characterization project. Additional information about this meeting is reported in the Executive Summary.

If you have any questions, comments, or need information about CGAP, please contact the NCI CGAP Help Desk.