Summaries & Associations of Study Results
TR-308 Chlorinated Paraffins: C12, 60% Chlorine
Target Organs and Levels of Evidence
NTP Technical Report Number 308
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| CHLORINATED PARAFFINS: C12, 60% CHLORINE 108171-26-2 |
08/14/85 | ADDITIVE FOR EXTREME PRESSURE LUBRICANT; FLAME RETARDANT IN RUBBER, PLASTIC, AND PAINT | Gavage R: 0,312,625, M: 0,125,250 MG/KG/50 PER GROUP | Southern Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | LIVER: NEOPLASTIC NODULE 0/50 10/50 16/48; CARCINOMA 0/50 3/50 2/48 | |||
| KIDNEY TUBULAR CELL: ADENOMA 0/50 7/50 3/49 ADENOCARCINOMA 0/50 2/50 0/49 COMBINED 0/50 9/50 3/49 | ||||
| MAY HAVE BEEN RELATED: | HEMATOPOIETIC SYSTEM: LEUKEMIA 7/50 12/50 14/50 | |||
| FR: CLEAR EVIDENCE | LIVER: NEOPLASTIC NODULE 0/50 4/50 7/50; CARCINOMA 0/50 1/50 1/50 | |||
| THYROID GLAND FOLLICULAR CELL: ADENOMA 0/50 6/50 3/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 6/50 6/50 | ||||
| MM: CLEAR EVIDENCE | LIVER: ADENOMA 11/50 20/50 29/50 OR CARCINOMA 11/50 15/50 17/50 COMBINED 2/50 34/50 38/50 | |||
| FM: CLEAR EVIDENCE | LIVER: ADENOMA 0/50 18/50 22/50 OR CARCINOMA 3/50 4/50 9/50 COMBINED 3/50 22/50 28/50 | |||
| THYROID GLAND FOLLICULAR CELL: ADENOMA 8/50 12/49 18/49 OR CARCINOMA 0/50 0/49 2/49 COMBINED 8/50 12/49 15/49 | ||||
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