AGENDA


*Monday, August 11, 2008*

7:30 – 8:30 a.m.	Registration

8:30 – 8:45 a.m.	Welcome Organizing Committee

8:45 – 10:15 a.m.	Overview

	Why Do Mutations in Ribosomal Proteins Mainly Affect Erythropoiesis? Harvey Lodish, The Whitehead Institute

	Ribosomal Mutations Cause p53-mediated Dark Skin and Pleiotropic Effects Kelly McGowan, Stanford University

	Identification of RPS14 as a 5q– Syndrome Gene by RNA Interference Screen Benjamin Ebert, Broad Institute of MIT and Harvard

10:15 – 10:30 a.m.	Break

10:30 – 11:30 a.m.	Structure and Function of the Ribosome

	Molecular Basis of Shwachman Diamond Syndrome Paul de Figueiredo, Texas A&M University

	Tom Kaufman (Invited), Indiana University

11:30 – 1:00 p.m.	The Nucleolus and rDNA Transcription

	RPS19 and Diamond Blackfan Anemia Mohandas Narla, New York Blood Bank

	Pathogenesis of the Erythroid Failure in Diamond Blackfan Anemia Colin Sieff, Harvard Medical School

1:00 – 2:00 p.m.	Lunch (on your own)

2:00 – 4:00 p.m.	Ribosomal Biogenesis

	Beware Imbalance in the Synthesis of Ribosomes Jonathan R. Warner, Albert Einstein College of Medicine��

	Physical and Functional Clusters of Ribosome Assembly Factors: Recruiting Strategies and Mechanisms to Regulate Pre-rRNA Processing John L. Woolford, Carnegie Mellon University

	New Insights into How We Make Ribosomes Susan J. Baserga, Yale University

	Yeast Models of Diamond Blackfan Anemia and Shwachman Diamond Syndrome Differ in Their Effect on the Synthesis and Function of Ribosomal Subunits Steven R. Ellis, University of Louisville

4:00 – 6:00 p.m.	POSTER SESSION


*Tuesday, August 12, 2008*

7:30 – 8:30 a.m.	Registration

8:30 – 11:00 a.m.	Ribosomes and Disease

	Clinical Features of Ribosomal Hematologic Diseases Blanche Alter, National Cancer Institute, National Institutes of Health

	Shwachman Diamond Syndrome: Clinical and Molecular Features Akiko Shimamura, University of Washington

	An Alternative rRNA Processing Pathway Generates a Specialized Ribosome That is Used for Nonsense-Mediated Decay Mark E. Schmitt, SUNY Upstate Medical University

	*Shwachman-Diamond Syndrome Mice Display ‘Minute-Like’ Phenotypes with Translational Insufficiency* Johanna Rommens, University of Toronto

	Ribosome Biogenesis and Bone Marrow Failure Monica Bessler, Washington University

11:00 – 12:30 p.m.	Summary and Discussion

12:30 p.m.	Adjournment