Testing Status of Agents at NTP
Decabromodiphenyl oxide
CASRN: 1163-19-5
Formula: C12-Br10-O
Synonyms/Common Names:
- 1,1'-OXYBIS(2,3,4,5,6-PENTABROMOBENZENE) (9CI)
Known Uses:
FLAME RETARDANT. FOR NITRILE RESINS, POLYESTER AND TEXTILE COATINGS. (TDB)
Nomination Background
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C55287) Completed
- NTIS No. PB86-247780
(Peer Review 08/14/1985)
Citation: Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CAS No. 1163-19-5) In F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB86-247780
(Peer Review 08/14/1985)
- 13-Week (Dosed-Feed)
(C55287) Completed
- NTIS No. PB86-247780
(Peer Review 08/14/1985)
Citation: Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CAS No. 1163-19-5) In F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,3100,50000 PPM/10 PER GROUP
- NTIS No. PB86-247780
(Peer Review 08/14/1985)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C55287) Report Complete
- TR-309 (NTIS No. PB86-247780)
(Peer Review 08/14/1985)
Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CAS No. 1163-19-5) In F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Some Evidence
- Female Rats Some Evidence
- Male Mice Equivocal Evidence
- Female Mice No Evidence
- Dose: 0,25000,50000 PPM/50 PER GROUP
- TR-309 (NTIS No. PB86-247780)
(Peer Review 08/14/1985)
Special Studies
- Absorption Disposition Metabolism Elimination (Intravenous; Dosed-Feed)
(S0210) Completed
- Citation: J. OF TOXIC. AND ENVIRON HEALTH VOL 22: 405-415 (1987) DISPOSITION OF DECABROMOBIPHENYL ETHER IN RATS DOSED INTRAVENOUSLY OR BY FEEDING. S.M. EL DAREER, J.R. KALIN, K.F. TILLERY, AND D.L. HILL
- M Rats: F344/N; M Rats: F344/N
- Dose: IV: 1 MG/KG
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(856353) Completed
- Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
- Chromosome Aberation Negative
- Sister Chromatid Exchange Negative
- Mouse Lymphoma
(490548) Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Negative
- Micronucleus
(A36713) Completed
- Rats: F344
- Male Positive
- Salmonella
(185983) Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Negative
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