The Cell Biology and Metabolism Program (CBMP) of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) carries out research in various areas of molecular cell biology, including the mechanisms of intracellular protein trafficking, the biogenesis and dynamics of intracellular organelles, the developmental control of the cell cycle, iron metabolism in humans and the genetic response to environmental stress.
Program Chief: Juan S. Bonifacino, Ph.D.
Group Leaders
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Juan S. Bonifacino Ph.D. The Section on Intracellular Protein Trafficking studies the molecular mechanisms involved in protein sorting in the endocytic and secretory pathways, and diseases caused by abnormalities in these pathways. |
| Gisela Storz, Ph.D. The Section on Environment Gene Regulation studies the problem of how organisms perceive environmental signals and transduce these signals into changes in gene expression and cell morphology. |
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Jennifer Lippincott-Schwartz, Ph.D. The Section on Organelle Biology studies the mechanisms by which intracellular organelles exchange components, and maintain and remodel their membranes throughout the cell cycle. |
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Ramanujan Hegde, M.D., Ph.D. The Section on Protein Biogenesis studies the biogenesis and metabolism of secretory and membrane proteins, and the diseases that arise from their misregulation. |
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Mary Lilly, Ph.D. The Unit on Cell Cycle Regulation studies the regulation of the cell cycle during oogenesis in Drosophila. |
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Irwin Arias, M.D. The Unit of Cellular Polarity studies the mechanism and regulation of hepatocellular polarity, the biology of bile canalicular ATP Binding Cassette transporters, and the relationship of these processes to biliary secretion and bile secretory failure (cholestasis). |
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Matthias Machner, Ph. D. The Unit of Microbial Pathogenesis studies host cell infection by the facultative intravacuolar pathogen Legionella pneumophila. |