Resources for Researchers : Pancreas : NIDDK

Resources for Researchers : Pancreas

                        Pancreas Databases, Registries and Information

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                        Beta Cell Biology Consortium (BCBC)

                        http://www.betacell.org/     EXIT Disclaimer

                        The mission of the BCBC is to facilitate interdisciplinary approaches that will advance our understanding of pancreatic islet cell development, regenerative capacity and function. The long-term goal is to develop a cell-based therapy, or treatments leading to controlled beta-cell renewal, in order to restore normal insulin production to diabetic patients.

                        For more information, contact Dr. Olivier Blondel, DEM, Director, Endocrine Systems Biology Program or Dr. Sheryl Sato , DEM, Director, Neurobiology of Obesity and Developmental Biology Programs.

                        Central NIDDK Repository for Biosamples and Data

                        http://www.niddkrepository.org     EXIT Disclaimer

                        On July 1, 2003, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) established Central NIDDK Repositories for biosamples and data collected in clinical studies. The purpose of the Central Repositories is to expand the usefulness of these studies by providing access to the biosamples and data to a wider research community beyond the end of the study.

                        For more information, contact Dr. Rebekah Rasooly, Deputy Director of the Division of Kidney, Urologic, and Hematologic Diseases.

                        Collaborative Islet Transplant Registry (CITR)

                        http://www.citregistry.org     EXIT Disclaimer

                        The mission of CITR is to expedite progress and promote safety in islet/beta cell transplantation through the collection, analysis, and communication of comprehensive and current data on all islet/beta cell transplants performed in North America and soon some transplants in Europe and Australia. An Annual Report that is available on the public web site. This site serves as a repository for general information concerning protocols, clinical transplantation sites, publications, and other information of interest to the general community.

                        For more information, contact Dr. Michael Appel, DEM, Director, Islet Biology and Transplantation Research Program.

                        Diabetes Genome Anatomy Project (DGAP)

                        http://www.diabetesgenome.org/     EXIT Disclaimer

                        The Diabetes Genome Anatomy Project (DGAP) represents a unique, multidimensional initiative whose goal is to unravel the interface between insulin action, insulin resistance and the genetics of type 2 diabetes. The overall goal of the project is to identify the sets of the genes involved in insulin action and the predisposition to type 2 diabetes, as well as the secondary changes in gene expression that occur in response to the metabolic abnormalities present in diabetes.

                        For more information, contact Dr. Olivier Blondel, DEM, Director, Endocrine Systems Biology Program.

                        Mouse Metabolic Phenotyping Centers (MMPC)

                        http://www.mmpc.org     EXIT Disclaimer

                        The Centers are housed at outstanding academic institutions, staffed by experts in state-of-the-art technology. Researchers can ship mice to one of the four Centers and obtain on a fee-for-service basis a range of complex exams used to characterize mouse metabolism, blood composition including hormones, energy balance, eating and exercise, organ function and morphology, physiology and histology. Many tests are done in living animals and are designed to elucidate subtle to complex traits that would define models of metabolic disease.

                        For more information, contact Dr. Maren Laughlin, DEM, Senior Advisor for Integrative Metabolism.

                        National Gene Vector Laboratories (NGVL)

                        http://www.ngvl.org/     EXIT Disclaimer

                        The National Gene Vector Laboratories (NGVL) are composed of an interactive group of academic production and pharm/tox laboratories whose primary goal is to provide eligible investigators with clinical grade vectors for phase I/II gene therapy clinical trials and to provide support for relevant pharmacology/toxicology studies leading up to clinical gene transfer protocols. If the application is approved, clinical grade material will be produced at no cost to the investigator.

                        For more information, contact Dr. Catherine McKeon, DEM, Senior Advisor for Genetic Research in Diabetes, Endocrinology and Metabolic Diseases.

                        Organ Procurement and Transplantation Network (OPTN)

                        http://www.optn.org/     EXIT Disclaimer

                        The U.S. Organ Procurement and Transplantation Network (OPTN) maintains a registry of human tissues in order to ensure the success and efficiency of the U.S. organ transplant system.

                        For more information, contact Dr. Thomas Eggerman, DEM, Director, Islet Transplantation Clinical Trials Program.

                        Pancreas Multicenter Clinical Research

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                        Clinical Trials in Organ Transplantation (CTOT)

                        http://www.ctotstudies.org/     EXIT Disclaimer

                        The Clinical Trials in Organ Transplantation (CTOT) project is a cooperative research program sponsored by NIAID, NIDDK & NHLBI. This consortium is conducting clinical and associated mechanistic studies to facilitate improved outcomes for abdominal (kidney & liver) and thoracic (heart & lung) transplant recipients; short and long-term graft and patient survival.

                        For more information, contact Dr. Catherine Meyers, KUH, Director, Inflammatory Kidney Diseases Program.

                        Collaborative Islet Transplant Registry (CITR)

                        http://www.citregistry.org     EXIT Disclaimer
                        The mission of CITR is to expedite progress and promote safety in islet/beta cell transplantation through the collection, analysis, and communication of comprehensive and current data on all islet/beta cell transplants performed in North America and soon some transplants in Europe and Australia. An Annual Report that is available on the public web site. This site serves as a repository for general information concerning protocols, clinical transplantation sites, publications, and other information of interest to the general community.

                        For more information, contact Dr. Michael Appel, DEM, Director, Islet Biology and Transplantation Research Program.

                        Islet Transplantation Trials for Type 1 Diabetes

                        http://www.isletstudy.org/     EXIT Disclaimer

                        A network of centers will conduct studies of islet transplantation in patients with type 1 diabetes to improve the safety and long-term success of methods for transplanting islets.

                        For more information, contact Dr. Thomas Eggerman, DEM, Director, Islet Transplantation Clinical Trials Program.

                        Pancreas Basic Research Networks

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                        Beta Cell Biology Consortium (BCBC)

                        http://www.betacell.org/     EXIT Disclaimer

                        The mission of the BCBC is to facilitate interdisciplinary approaches that will advance our understanding of pancreatic islet cell development, regenerative capacity and function. The long-term goal is to develop a cell-based therapy, or treatments leading to controlled beta-cell renewal, in order to restore normal insulin production to diabetic patients.

                        For more information, contact Dr. Olivier Blondel, DEM, Director, Endocrine Systems Biology Program or Dr. Sheryl Sato , DEM, Director, Neurobiology of Obesity and Developmental Biology Programs.

                        Central NIDDK Repository for Biosamples and Data

                        http://www.niddkrepository.org     EXIT Disclaimer

                        On July 1, 2003, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) established Central NIDDK Repositories for biosamples and data collected in clinical studies. The purpose of the Central Repositories is to expand the usefulness of these studies by providing access to the biosamples and data to a wider research community beyond the end of the study.

                        For more information, contact Dr. Rebekah Rasooly, Deputy Director of the Division of Kidney, Urologic, and Hematologic Diseases.

                        Diabetes Genome Anatomy Project (DGAP)

                        http://www.diabetesgenome.org/     EXIT Disclaimer

                        The Diabetes Genome Anatomy Project (DGAP) represents a unique, multidimensional initiative whose goal is to unravel the interface between insulin action, insulin resistance and the genetics of type 2 diabetes. The overall goal of the project is to identify the sets of the genes involved in insulin action and the predisposition to type 2 diabetes, as well as the secondary changes in gene expression that occur in response to the metabolic abnormalities present in diabetes.

                        For more information, contact Dr. Olivier Blondel, DEM, Director, Endocrine Systems Biology Program.

                        Islet Cell Resource Centers (ICR)

                        http://icr.coh.org/     EXIT Disclaimer

                        The three major goals of the ICRs are: 1) to provide pancreatic islets of cGMP-quality to eligible investigators for use in FDA approved, IRB-approved transplantation protocols; 2) to optimize the harvest, purification, function, storage, and shipment of islets while developing tests that characterize the quality and predict the effectiveness of islets transplanted into patients with diabetes mellitus; and 3) to provide pancreatic islets for basic science studies.

                        For more information, contact Dr. Michael Appel, DEM, Director, Islet Biology and Transplantation Research Program.

                        Mouse Metabolic Phenotyping Centers (MMPC)

                        http://www.mmpc.org     EXIT Disclaimer

                        The Centers are housed at outstanding academic institutions, staffed by experts in state-of-the-art technology. Researchers can ship mice to one of the four Centers and obtain on a fee-for-service basis a range of complex exams used to characterize mouse metabolism, blood composition including hormones, energy balance, eating and exercise, organ function and morphology, physiology and histology. Many tests are done in living animals and are designed to elucidate subtle to complex traits that would define models of metabolic disease.

                        For more information, contact Dr. Maren Laughlin, DEM, Senior Advisor for Integrative Metabolism.

                        Network of Minority Research Investigators (NMRI)

                        http://nmri.niddk.nih.gov/

                        NMRI is a communication network of current and potential biomedical research investigators and technical personnel from traditionally under-served communities: African American, Hispanic American, American Indian, Alaskan Native, Native Hawaiian, and other Pacific Islanders. The major objective of the network is to encourage and facilitate participation of members of underrepresented racial and ethnic minority groups in the conduct of biomedical research in the fields of diabetes, endocrinology, metabolism, digestive diseases, nutrition, kidney, urologic and hematologic diseases. A second objective is to encourage and enhance the potential of the underrepresented minority investigators in choosing a biomedical research career in these fields. An important component of this network is promotion of two-way communications between network members and the NIDDK.

                        For more information, contact Ms. Winnie Martinez, Program Analyst, Office of Minority Health Research Coordination.

                        Non-human Primate Transplantation Tolerance Cooperative Study Group (NHPCSG)

                        http://www.niddk.nih.gov/fund/diabetesspecialfunds/consortia/NHP.pdf

                        The NHPCSG, a multi-institution consortium, was established to evaluate the safety and efficacy of novel donor-specific, tolerance induction therapies in non-human primate (NHP) models of kidney and islet transplantation. The program also supports research into the immunological mechanisms of tolerance induction and development of surrogate markers for the induction, maintenance, and loss of tolerance.

                        For more information, contact Dr. Michael Appel, DEM, Director, Islet Biology and Transplantation Research Program.

                        Pancreas Reagents

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                        Beta Cell Biology Consortium (BCBC)

                        http://www.betacell.org/     EXIT Disclaimer

                        The mission of the BCBC is to facilitate interdisciplinary approaches that will advance our understanding of pancreatic islet cell development, regenerative capacity and function. The long-term goal is to develop a cell-based therapy, or treatments leading to controlled beta-cell renewal, in order to restore normal insulin production to diabetic patients.

                        For more information, contact Dr. Olivier Blondel, DEM, Director, Endocrine Systems Biology Program or Dr. Sheryl Sato , DEM, Director, Neurobiology of Obesity and Developmental Biology Programs.

                        Central NIDDK Repository for Biosamples and Data

                        http://www.niddkrepository.org     EXIT Disclaimer

                        On July 1, 2003, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) established Central NIDDK Repositories for biosamples and data collected in clinical studies. The purpose of the Central Repositories is to expand the usefulness of these studies by providing access to the biosamples and data to a wider research community beyond the end of the study.

                        For more information, contact Dr. Rebekah Rasooly, Deputy Director of the Division of Kidney, Urologic, and Hematologic Diseases.

                        National Gene Vector Laboratories (NGVL)

                        http://www.ngvl.org/     EXIT Disclaimer

                        The National Gene Vector Laboratories (NGVL) are composed of an interactive group of academic production and pharm/tox laboratories whose primary goal is to provide eligible investigators with clinical grade vectors for phase I/II gene therapy clinical trials and to provide support for relevant pharmacology/toxicology studies leading up to clinical gene transfer protocols. If the application is approved, clinical grade material will be produced at no cost to the investigator.

                        For more information, contact Dr. Catherine McKeon, DEM, Senior Advisor for Genetic Research in Diabetes, Endocrinology and Metabolic Diseases.

                        Pancreas Services

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                        Beta Cell Biology Consortium (BCBC)

                        http://www.betacell.org/     EXIT Disclaimer

                        The mission of the BCBC is to facilitate interdisciplinary approaches that will advance our understanding of pancreatic islet cell development, regenerative capacity and function. The long-term goal is to develop a cell-based therapy, or treatments leading to controlled beta-cell renewal, in order to restore normal insulin production to diabetic patients.

                        For more information, contact Dr. Olivier Blondel, DEM, Director, Endocrine Systems Biology Program or Dr. Sheryl Sato , DEM, Director, Neurobiology of Obesity and Developmental Biology Programs.

                        Center for Inherited Disease Research (CIDR)

                        http://www.cidr.jhmi.edu     EXIT Disclaimer

                        A centralized facility established to provide genotyping and statistical genetics services for investigators seeking to identify genes that contribute to human disease. CIDR concentrates primarily on multifactorial hereditary disease although linage analysis of single gene disorders can also be accommodated.

                        For more information, contact Dr. Catherine McKeon, DEM, Senior Advisor for Genetic Research in Diabetes, Endocrinology and Metabolic Diseases.

                        Central NIDDK Repository for Biosamples and Data

                        http://www.niddkrepository.org     EXIT Disclaimer

                        On July 1, 2003, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) established Central NIDDK Repositories for biosamples and data collected in clinical studies. The purpose of the Central Repositories is to expand the usefulness of these studies by providing access to the biosamples and data to a wider research community beyond the end of the study.

                        For more information, contact Dr. Rebekah Rasooly, Deputy Director of the Division of Kidney, Urologic, and Hematologic Diseases.

                        Islet Cell Resource Centers (ICR)

                        http://icr.coh.org/     EXIT Disclaimer

                        The three major goals of the ICRs are: 1) to provide pancreatic islets of cGMP-quality to eligible investigators for use in FDA approved, IRB-approved transplantation protocols; 2) to optimize the harvest, purification, function, storage, and shipment of islets while developing tests that characterize the quality and predict the effectiveness of islets transplanted into patients with diabetes mellitus; and 3) to provide pancreatic islets for basic science studies.

                        For more information, contact Dr. Michael Appel, DEM, Director, Islet Biology and Transplantation Research Program.

                        Mouse Metabolic Phenotyping Centers (MMPC)

                        http://www.mmpc.org     EXIT Disclaimer

                        The Centers are housed at outstanding academic institutions, staffed by experts in state-of-the-art technology. Researchers can ship mice to one of the four Centers and obtain on a fee-for-service basis a range of complex exams used to characterize mouse metabolism, blood composition including hormones, energy balance, eating and exercise, organ function and morphology, physiology and histology. Many tests are done in living animals and are designed to elucidate subtle to complex traits that would define models of metabolic disease.

                        For more information, contact Dr. Maren Laughlin, DEM, Senior Advisor for Integrative Metabolism.

                        Rapid Access to Intervention Development (NIH RAID)

                        http://nihroadmap.nih.gov/raid/     EXIT Disclaimer

                        NIH RAID provides a variety of contract services researchers need to bring promising potential therapeutics to trial.



                        Sequencing the NOD Mouse

                        http://www.niddk.nih.gov/fund/diabetesspecialfunds/consortia-networks/nod.htm     EXIT Disclaimer

                        This project is a collaboration of four centers, working on a genome-wide basis, to generate a finished sequence of the non-obese diabetic (NOD) mouse genome, dovetailing with a number of targeted sequencing programs.

                        For more information, contact Dr. Beena Akolkar, DEM, Director, Immunopathogenesis and Genetics of Type 1 Diabetes Program.

                        Pancreas Standardization Programs

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                        There are none at this time. Please check back.

                        Pancreas Tissues, Cells, Animals

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                        Beta Cell Biology Consortium (BCBC)

                        http://www.betacell.org/     EXIT Disclaimer

                        The mission of the BCBC is to facilitate interdisciplinary approaches that will advance our understanding of pancreatic islet cell development, regenerative capacity and function. The long-term goal is to develop a cell-based therapy, or treatments leading to controlled beta-cell renewal, in order to restore normal insulin production to diabetic patients.

                        For more information, contact Dr. Olivier Blondel, DEM, Director, Endocrine Systems Biology Program or Dr. Sheryl Sato , DEM, Director, Neurobiology of Obesity and Developmental Biology Programs.

                        Central NIDDK Repository for Biosamples and Data

                        http://www.niddkrepository.org     EXIT Disclaimer

                        On July 1, 2003, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) established Central NIDDK Repositories for biosamples and data collected in clinical studies. The purpose of the Central Repositories is to expand the usefulness of these studies by providing access to the biosamples and data to a wider research community beyond the end of the study.

                        For more information, contact Dr. Rebekah Rasooly, Deputy Director of the Division of Kidney, Urologic, and Hematologic Diseases.

                        Collaberative Projects in Proteomics or Metabolomics for Type 1 Diabetes

                        http://www.niddk.nih.gov/fund/diabetesspecialfunds/proteomics/

                        To encourage the application of proteomic and metabolomic technologies to study type 1 diabetes and its complications, the NIDDK is fostering collaborations between researchers studying type 1 diabetes and investigators with expertise in Proteomics and/or Metabolomics.

                        For more information, contact Dr. Salvatore Sechi, DEM, Director, Proteomic Program.

                        Islet Cell Resource Centers (ICR)

                        http://icr.coh.org/     EXIT Disclaimer

                        The three major goals of the ICRs are: 1) to provide pancreatic islets of cGMP-quality to eligible investigators for use in FDA approved, IRB-approved transplantation protocols; 2) to optimize the harvest, purification, function, storage, and shipment of islets while developing tests that characterize the quality and predict the effectiveness of islets transplanted into patients with diabetes mellitus; and 3) to provide pancreatic islets for basic science studies.

                        For more information, contact Dr. Michael Appel, DEM, Director, Islet Biology and Transplantation Research Program.

                        Mouse Metabolic Phenotyping Centers (MMPC)

                        http://www.mmpc.org     EXIT Disclaimer

                        The Centers are housed at outstanding academic institutions, staffed by experts in state-of-the-art technology. Researchers can ship mice to one of the four Centers and obtain on a fee-for-service basis a range of complex exams used to characterize mouse metabolism, blood composition including hormones, energy balance, eating and exercise, organ function and morphology, physiology and histology. Many tests are done in living animals and are designed to elucidate subtle to complex traits that would define models of metabolic disease.

                        For more information, contact Dr. Maren Laughlin, DEM, Senior Advisor for Integrative Metabolism.

                        Mutant Mouse Regional Resource Centers (MMRRC)

                        http://www.mmrrc.org/     EXIT Disclaimer

                        The goal of the MMRRC program is to enhance the availability of and help ensure the quality of genetically modified mice for biomedical research of human and animal biology and disease.

                        For more information, contact Dr. Kristin Abraham, DEM, Director, Cell Signaling and Diabetes Centers Program.

                        Non-human Primate Transplantation Tolerance Cooperative Study Group (NHPCSG)

                        http://www.niddk.nih.gov/fund/diabetesspecialfunds/consortia/NHP.pdf

                        The NHPCSG, a multi-institution consortium, was established to evaluate the safety and efficacy of novel donor-specific, tolerance induction therapies in non-human primate (NHP) models of kidney and islet transplantation. The program also supports research into the immunological mechanisms of tolerance induction and development of surrogate markers for the induction, maintenance, and loss of tolerance.

                        For more information, contact Dr. Michael Appel, DEM, Director, Islet Biology and Transplantation Research Program.

                        Type 1 Diabetes Mouse Repository at Jackson Laboratory (T1DR)

                        http://www.jax.org/t1dr/     EXIT Disclaimer

                        NIDDK has funded a Type 1 Diabetes Resource (T1DR) at The Jackson Laboratory (TJL). The purpose of this resource is to collect and cryopreserve ~150 mouse stocks important to research in type 1 diabetes.

                        For more information, contact Dr. Kristin Abraham, DEM, Director, Cell Signaling and Diabetes Centers Program.

                        Pancreas Useful Tools

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                        There are none at this time. Please check back.

                        Page last updated: January 05, 2009

                        General inquiries may be addressed to: Office of Communications & Public Liaison
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                        For information about NIDDK programs: 301.496.3583

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