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7:30 a.m. – 8:00 a.m. |
Registration |
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8:00 a.m. – 8:15 a.m. |
Welcoming Remarks
Dr. Griffin Rodgers, Director, NIDDK |
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8:15 a.m. – 9:00 a.m. |
Heme Biosynthesis: An Overview and Introduction to the Workshop
James Kushner, University of Utah |
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9:00 a.m. – 9:45 a.m. |
In vivo Functional Analysis of Two 5-Aminolevulinate Synthase Isozymes and Heme Oxygenase-1 in Mouse
Masi Yamamoto, Tohoku University |
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9:45 a.m. – 10:00 a.m. |
Break |
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10:00 a.m. – 10:30 a.m. |
Heme Is Required for MicroRNA Processing in Human Cells
Feng Guo, University of California at Los Angeles School of Medicine |
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10:30 a.m. – 11:00 a.m. |
Regulation of Gene Expression by Heme-Regulated eIF2α Kinase during Stress Erythropoiesis of Iron Deficiency
Jane-Jane Chen, Massachusetts Institute of Technology |
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11:00 a.m. – 11:30 a.m. |
Regulation of Gene Expression by Heme through Bach2
Kazuhiko Igarashi, Tohoku University |
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11:30 a.m. – 1:00 p.m. |
LUNCH (on your own) |
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1:00 p.m. – 1:30 p.m. |
Genomic Organization of Gene Expression during Hematopoiesis
Mark Groudine, Fred Hutchinson Cancer Research Center |
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1:30 p.m. – 2:00 p.m. |
An Erythroid Chaperone that Stabilizes the Heme Pocket of Bound Alpha Globin
Mitch Weiss, Children’s Hospital of Philadelphia |
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2:00 p.m. – 2:30 p.m. |
hem6: an ENU-induced Recessive Hypochromic Microcytic Anemia Mutation in the Mouse
Mark Fleming, Children’s Hospital Boston |
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2:30 p.m. – 2:45 p.m. |
Break |
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2:45 p.m. – 3:15 p.m. |
Studies of Heme Export, Heme-Iron Trafficking, and Erythropoiesis
Jan Abkowitz, University of Washington |
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3:15 p.m. – 3:45 p.m. |
Spatial Logistics for Enzymes of Heme Synthesis
Harry Dailey, University of Georgia |
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3:45 p.m. – 4:15 p.m. |
Mitoferrin1, a Solute Carrier, Is Essential for Mitochondrial Iron Acquisition during Vertebrate Erythropoiesis
Barry Paw, Brigham and Women’s Hospital |
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4:15 p.m. – 4:45 p.m. |
The Role of the Mitoferrins in Mammalian Mitochondrial Iron Metabolism
Jerry Kaplan, University of Utah |
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4:45 p.m. – 5:15 p.m. |
A Signal for Trafficking of ABCB6 and Other ABC Transporters
John Schuetz, St. Jude Children’s Hospital |
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5:15 p.m. – 5:45 p.m. |
Iron and Heme: Their Exquisite Relationship Makes Blood Red
Prem Ponka, McGill University |
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6:00 p.m. |
Dinner (on your own) |
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7:00 a.m. – 7:30 a.m. |
Registration |
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7:30 a.m. – 8:30 a.m. |
* HOT TOPICS! * |
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8:30 a.m. – 9:00 a.m. |
Heme Catabolism by Heme Oxygenase: A Pathway to Cytoprotection
Karl Nath, Mayo Clinic |
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9:00 a.m. – 9:30 a.m. |
Cerebral Malaria, Free Heme, Heme Oxygenase-1 and Carbon Monoxide: Shedding New Light on an Old Disease
Maria Mota, Institute of Molecular Medicine, Portugal |
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9:30 a.m. – 9:45 a.m. |
Break |
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9:45 a.m. – 10:15 a.m. |
Effects of a Mitochondrial Lesion on Red Cell Development
Jeff Friedman, Scripps Institute |
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10:15 a.m. – 10:45 a.m. |
Animal Models of Porphyria
Robert Desnick, Mount Sinai School of Medicine |
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10:45 a.m. – 11:15 a.m. |
Effective Gene Therapy of Congenital Erythropoietic Porphyria Mice is Facilitated by a Survival Advantage of Corrected Erythroid Cells
Hubert de Verneuil, INSERM |
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11:15 a.m. – 12:30 p.m. |
Summary and Adjournment (all registrants) |
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