Hepatobiliary Pathophysiology Study Section [HBPP]

[HBPP Membership Roster] [HBPP Meeting Rosters]


The Hepatobiliary Pathophysiology [HBPP] study section reviews applications involving pathophysiology and treatment of inherited and acquired viral and non viral hepatobiliary diseases; mechanisms of  liver injury, repair, regeneration, and transplantation; liver cell biology, immunology and inflammation; cholesterol and bile salt metabolism; hepatobiliary transporters and ion channels; and alcohol metabolism and disease.

Specific areas covered by HBPP:

  • The use of isolated parenchymal and non-parenchymal cells of the liver as they relate to the pathogenesis of liver disease and progenitor cell therapy of genetic and acquired hepatobiliary diseases.
  • Mechanisms of bile formation, bile salt synthesis and cholestasis; mechanisms of hepatic cholesterol and lipid metabolism and regulation of lipoprotein genes; physiologic mechanisms of hepatobiliary transport.
  • Inflammatory response of the liver to injury or infection and mechanism of hepatocyte injury including immune response, oxidative stress, apoptosis, pro- and anti-inflammatory mediators. Signal transduction pathways and neuromediators.
  • Liver injury, repair, regeneration, development, and transplantation. Liver ischemia-reperfusion injury and regulation of splanchnic blood flow as it pertains to mechanisms of portal hypertension.
  • Cellular and molecular mechanisms, gene regulation, pathogenesis, and treatment of liver diseases, such as, fibrosis and cirrhosis; cholangiopathies; gallstones and gallbladder disease; viral hepatitis as it relates to the pathogenesis of hepatobiliary disease; non-alcoholic fatty liver and alcoholic liver diseases.

Study sections with most closely related areas of similar science listed in rank order are:

Xenobiotic and Nutrient Disposition and Action [XNDA]
Gastrointestinal Cell and Molecular Biology [GCMB]
Innate Immunity And Inflammation [III]
Integrative Nutrition and Metabolic Processes [INMP]
Virology A [VIRA]
Virology B [VIRB]


 



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