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Sponsored by: |
National Institute of Mental Health (NIMH) |
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Information provided by: | National Institute of Mental Health (NIMH) |
ClinicalTrials.gov Identifier: | NCT00304174 |
This study will evaluate whether people with bulimia nervosa will binge eat in a structured laboratory setting and display behavioral patterns similar to those of individuals who are dependent on drugs.
Condition | Intervention |
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Bulimia Nervosa Eating Disorders |
Behavioral: Motivation to eat |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Translational Research on Eating Disorders: Behavioral Assessment of Motivation to Eat |
Estimated Enrollment: | 32 |
Study Start Date: | May 2005 |
Estimated Study Completion Date: | February 2009 |
Groups/Cohorts | Assigned Interventions |
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1
Participants with bulimia nervosa
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Behavioral: Motivation to eat
Participants will use a computer program to earn food (a yogurt shake) by tapping on the keyboard. More taps on the keyboard will result in a larger amount of food earned by the end of the day. Once experimentation is complete on Day 1, participants will be instructed to eat as much as they can. On Days 2 and 3, participants will be given a small serving of the yogurt shake prior to beginning the computer task. Following the computer task, they will be instructed to either eat until they are comfortable (without restricting or binging), or eat as much as they can.
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2
Control participants without bulimia nervose who weigh between 80% and 120% of ideal weight
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Behavioral: Motivation to eat
Participants will use a computer program to earn food (a yogurt shake) by tapping on the keyboard. More taps on the keyboard will result in a larger amount of food earned by the end of the day. Once experimentation is complete on Day 1, participants will be instructed to eat as much as they can. On Days 2 and 3, participants will be given a small serving of the yogurt shake prior to beginning the computer task. Following the computer task, they will be instructed to either eat until they are comfortable (without restricting or binging), or eat as much as they can.
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Bulimia nervosa (BN) is a serious eating disorder that is characterized by frequent uncontrolled eating binges. These binges are often followed by compensatory behavior, including the following: self-induced vomiting; misuse of laxatives, diuretics, enemas, or other medications to induce purging; fasting; or excessive exercise. If left untreated, BN can lead to many serious health issues: tooth decay; irregular menstruation; bowel damage; constipation; heart and kidney disease; intestinal damage; puffiness, especially in the face and fingers; increased hair growth on the face and body; and mineral imbalances in the body. Similar to drug abuse disorders, food-related thinking and disordered eating behavior can interfere with other occupational and social activities, as well. This study will evaluate whether people with bulimia nervosa will binge eat in a structured laboratory setting and display behavioral patterns similar to those of individuals who are dependent on drugs.
Interested participants will first report to the study site for a screening visit, during which they will be assessed for eligibility using blood tests and an interview. Eligible participants will return to the study site on 3 additional days. Participants will be asked to refrain from eating or drinking between 10 P.M. each night before reporting to the study site and 10 A.M. the next day. Each day, participants will receive breakfast, after which they will not be allowed to eat or drink until the end of the day. Participants will then use a computer program to earn food (a yogurt shake) by tapping on the keyboard. More taps on the keyboard will result in a larger amount of food earned by the end of the day. Once experimentation is complete on Day 1, participants will be instructed to eat as much as they can. On Days 2 and 3, participants will be given a small serving of the yogurt shake prior to beginning the computer task. Following the computer task, they will be instructed to either eat until they are comfortable (without restricting or binging), or eat as much as they can. A private bathroom will be available if needed. All participants, including those who did not meet criteria for participation, will be offered treatment at the study clinic once the study is complete.
Ages Eligible for Study: | 18 Years to 45 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Participants who meet DSM-IV criteria for bulimia nervosa and control participants who weigh between 80 and 120% of ideal weight
Inclusion Criteria:
Participants with Bulimia Nervosa:
Control Group:
Exclusion Criteria:
Participants with Bulimia Nervosa:
Control Group:
Contact: Amanda J. Brown, BA | 212-543-5151 | edru@pi.cpmc.columbia.edu |
United States, New York | |
Eating Disorders Clinic, New York State Psychiatric Institute | Recruiting |
New York, New York, United States, 10032 | |
Principal Investigator: B. T. Walsh, MD |
Principal Investigator: | B. T. Walsh, MD | New York State Psychiatric Institute at Columbia University Medical Center |
Responsible Party: | The New York State Psychiatric Institute ( B. Timothy Walsh, MD ) |
Study ID Numbers: | R21 MH65024-05, DNBBS 72-NBR |
Study First Received: | March 15, 2006 |
Last Updated: | September 23, 2008 |
ClinicalTrials.gov Identifier: | NCT00304174 |
Health Authority: | United States: Federal Government |
Signs and Symptoms Bulimia Nervosa Signs and Symptoms, Digestive Mental Disorders |
Bulimia Eating Disorders Hyperphagia |
Pathologic Processes Disease |