Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
National Institute of Mental Health (NIMH) |
---|---|
Information provided by: | National Institute of Mental Health (NIMH) |
ClinicalTrials.gov Identifier: | NCT00345943 |
The aim of this project is to use both functional MRI (fMRI) and behavioral measures to investigate how disturbances in frontostriatal neural systems contribute to the impulsive and habitual binge-eating behaviors in patients with Bulimia Nervosa (BN). Findings from this study will have wide-ranging importance for our understanding of the development and treatment of BN.
Condition | Intervention |
---|---|
Eating Disorders |
Other: fMRI Behavioral: Neuropsychological Testing |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | An fMRI Study of Self-Regulation in Adolescents With Bulimia Nervosa |
Estimated Enrollment: | 80 |
Study Start Date: | October 2004 |
Estimated Study Completion Date: | November 2010 |
Estimated Primary Completion Date: | November 2010 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
---|---|
1
Adolescents with Bulimia Nervosa or subclinical Bulimia Nervosa
|
Other: fMRI
Functional Magnetic Resonance Imaging scans
Behavioral: Neuropsychological Testing
Neuropsychological tests
|
2
Healthy control adolescents
|
Other: fMRI
Functional Magnetic Resonance Imaging scans
Behavioral: Neuropsychological Testing
Neuropsychological tests
|
Patients with Bulimia Nervosa (BN) have difficulty regulating impulsive behaviors as suggested by their binge-eating and purging, as well as the high incidence of drug abuse and shoplifting in this population. Understanding dysfunction in the frontostriatal circuitry that mediates self-regulatory control processes will aid development of new therapeutics for the impulsivity associated with BN. Thus we aim to use fMRI and neuropsychological measures to investigate the functioning of frontostriatal systems and self-regulatory control processes in adolescents with BN.
Participation in this study includes 4 sections: Neuropsychological Tests, Diagnostic interviews, Pregnancy Test, and MRI scan. All efforts are made to coordinate procedures into one day, and they require between 4 and 5 hours of the participant's time. The option of splitting participation into two study days is also offered for participants who find it more convenient. Participants are compensated with $100 in the form of a check, which is mailed to their home address.
Ages Eligible for Study: | 12 Years to 21 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Adolescents (ages 12-21 years) with bulimia nervosa and age, gender, and weight-matched controls
Inclusion Criteria:
Exclusion Criteria:
Contact: Laura J. Berner, BA | 212-543-5316 | lb2518@columbia.edu |
Contact: Rebecca Shingleton, MA | 212-543-5151 | rshingl@pi.cpmc.columbia.eduedu |
United States, New York | |
New York State Psychiatric Institute at Columbia University Medical Center | Recruiting |
New York, New York, United States, 10032 |
Principal Investigator: | Rachel Marsh, PhD | Columbia University |
Responsible Party: | The New York State Psychiatric Institute ( Rachel Marsh, PhD ) |
Study ID Numbers: | K01 MH77652 |
Study First Received: | June 28, 2006 |
Last Updated: | October 21, 2008 |
ClinicalTrials.gov Identifier: | NCT00345943 |
Health Authority: | United States: Federal Government |
Eating Disorders Bulimia Nervosa Bulimia fMRI Magnetic Resonance Imaging |
Signs and Symptoms Bulimia Nervosa Signs and Symptoms, Digestive Mental Disorders |
Bulimia Eating Disorders Hyperphagia |