HIV/AIDS Research at the NCI

Tentative Agenda

November 1-2, 2007
Masur Auditorium, Bldg 10
National Institutes of Health, Bethesda, MD

Thursday November 1, 2007

Welcome and Introductions
8:45	John Niederhuber, Director, NCI Jack Whitescarver, Director, OAR Samuel Broder, Former NCI Director; Chief Medical Officer, Celera

Keynote Address
9:10	Robert Gallo, Director, Institute of Human Virology “A Snapshot of the Role of NCI in the History of HIV/AIDS Research and Thoughts About the Present and Future”

10:00	Break

Session 1. AIDS Malignancies
10:30	Robert Yarchoan, NCI “Overview: The changing face of malignancies in AIDS”
10:40	Riccardo Dalla-Favera, Institute for Cancer Genetics “Molecular genetics of HIV-associated B cell lymphoma”
11:00	Richard Little, NCI “Treatment Advances for AIDS-Defining Cancers: Contributions of NCI Intramural Investigators”
11:20	Denise Whitby, NCI “Advances since the discovery of Kaposi’s sarcoma-associated herpesvirus”
11:40	Douglas Lowy, NCI “HPV vaccination and other approaches to prevent cervical cancer”

12:00	Lunch

1:00	Poster Session

Session 2. HIV Virology & Molecular Pathogenesis
2:10	Larry Arthur, NCI “Overview: Immunodeficiency Virus Membrane Glycoproteins”
2:20	Sriram Subramaniam, NCI “Electron Tomography of HIV and Structural Mechanisms of Viral Entry”
2:40	Barbara Felber, NCI “A long journey with HIV: From molecular biology and nuclear export to DNA vaccines”
3:00	Eric Freed, NCI “Inhibition of HIV-1 Maturation”
3:20	Louis Henderson, NCI “A brief and personal review of retroviral nucleocapsid proteins, their zinc fingers and role in AIDS vaccine research at NCI-Frederick”

3:40	Break

Session 3. Immunology/Immunopathology
4:10	Gene Shearer, NCI “Overview: Immune regulation in HIV disease”
4:20	Jean-Philippe Herbeuval, Hopital Necker, Paris “Regulation of TRAIL by pDC: Involvement of TLR7 and IFN-alpha”
4:40	Adriano Boasso, NCI “HIV immunopathogenesis: How innate ant-viral immunity cripples adaptive T cell responses”
5:00	Elias Haddad, University of Montreal, Canada “FOXO3a controls the persistence of memory CD4+ T cells in chronic HIV infection”
5:20	Claire Chougnet, Cincinnati Children’s Hospital “Regulatory T cells in HIV infection: A Complex Balancing Act”

Friday November 2, 2007

Keynote Address
9:00	Anthony Fauci, Director, NIAID “HIV/AIDS: Much Accomplished, Much to Do”

9:40	Break

Session 4. Vaccines/Immunotherapy
10:10	Jay Berzofsky, NCI “Overview: Strategies for HIV vaccines”
10:20	George Shaw, University of Alabama-Birmingham “Identification of the Transmitted HIV-1 Envelope and Complete Viral Proteome”
10:40	Genoveffa Franchini, NCI “Immunomodulatory Approaches for the Therapy of HIV Infection: Lessons from the Rhesus Macaque Model”
11:00	Jeffrey Lifson, NCI “Production of Whole Inactivated Retrovirus Virions with Functional Envelope Glycoproteins: Approaches and Applications”
11:20	Marjorie Robert-Guroff, NCI “Replication-competent adenovirus vectors for HIV vaccine development”

11:40	Lunch

Keynote Address
1:00	Beatrice Hahn, University of Alabama-Birmingham “The Ape Origins of HIV-1: How Does the Gorilla fit into the Equation?”

Session 5. Epidemiology
1:40	Mary Carrington, NCI “Overview: The Impact of Host Genetic and Environmental Factors on the HIV Epidemic”
1:50	Stephen O’Brien, NCI “Genetic Architecture of Complex Infectious Diseases”
2:10	William Blattner, Institute of Human Virology “Basic discovery to public health: global access to care and treatment”
2:30	Xiaojiang Gao, NCI “Immunogenetic Polymorphisms and their effect on HIV infection and AIDS progression”
2:50	James Goedert, NCI “Modes of transmission and natural history of HIV”

3:10	Break

Session 6. Drug Development/Resistance
3:40	Stephen Hughes, NCI “Overview: The Problem of Drug Resistance”
3:50	Hiroaki Mitsuya, NCI “Development of Antiviral Therapy of HIV Infection: From AZT to Darunavir”
4:10	Yves Pommier, NCI “Stilbenedisulfonic acid derivatives: Novel inhibitors of Integrase targeting the enzyme C-terminal domain”
4:30	Vineet KewalRamani, NCI “Fourth and Goal: Preventing HIV-1 Nuclear Entry”
4:50	John Coffin, Tufts University “HIV pathogenesis, evolution, and resistance”

Closing Remarks
5:10	Stuart Le Grice, Head, Center of Excellence in HIV/AIDS and Cancer Virology