Phospho-Signaling Networks, Disease Mechanisms and Clinical Outcome at the Single Cell Level |
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| Launch in standalone player | |
| Air date: | Wednesday, September 19, 2007, 4:15:00 PM |
| Category: | Immunology |
| Runtime: | 75 minutes |
| NLM Title: | Phospho-signaling networks, disease mechanisms, and clinical outcome at the single cell level [electronic resource] / Garry Nolan. |
| Series: | Mechanistic insights from the single cell |
| Author: | Nolan, Garry P. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2007] |
| Other Title(s): | Mechanistic insights from the single cell |
| Abstract: | (CIT): Dr. Nolan's laboratory at the Stanford University School of Medicine focuses on the analysis of biological events at the single cell level using novel genetic and FACS-based approaches at the intersection of immunology, biochemistry, and cancer. The laboratory studies phospho-protein immune cell and cancer signaling, and other metabolic parameters by analysis of biochemical functions at the single cell level in primary cell populations. This includes interrogation of cancer (Cell, 2004) and immune signaling networks in complex cell populations (Science, 2005) and using multiparameter data to stratify signaling maps from patient samples. Dr. Nolan is currently focused on the clinical and commercial development of diagnostics for use in clinical trial studies. Dr. Nolan received his Ph.D. in Genetics at Stanford University under the mentorship of Leonard and Leonore Herzenberg (co-developers of the Fluorescence Activated Cell Sorter) where he worked on the cloning of CD8 and development of the first single cell reporter gene assays. Dr. Nolan did his postdoctoral work in the laboratory of Nobelist David Baltimore at MIT, where he cloned and characterized the p65 subunit of NFkB. a central molecule in inflammation and cancer biology. |
| Subjects: | Autoimmune Diseases Flow Cytometry Neoplasms Phosphoproteins Signal Transduction |
| Publication Types: | Government Publications Lectures |
| Download: | Download
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| NLM Classification: | WD 305 |
| NLM ID: | 101317950 |
| CIT File ID: | 14035 |
| CIT Live ID: | 6125 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14035 |