National Toxicology Program

CASRN: 108-78-1

Formula: C3-H6-N6

Synonyms/Common Names:

• 1,3,5-TRIAZINE-2,5,6-TRIAMINE (9CI)

Known Uses:

INTERMEDIATE FOR AMINO RESINS AND PLASTICS, ADHESIVES FOR WOOD, FLOORING, LEATHER TANNING (HSDB 1990)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C50715) Completed 
  • NTIS No. PB83-202630  (Peer Review 06/16/1982)
    Citation: Carcinogenesis Bioassay of Melamine (CAS No. 108-78-1) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C50715) Completed 
  • NTIS No. PB83-202630  (Peer Review 06/16/1982)
    Citation: Carcinogenesis Bioassay of Melamine (CAS No. 108-78-1) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,750,12000, M: 0,6000,18000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C50715) Report Complete 
  • TR-245 (NTIS No. PB83-202630)  (Peer Review 06/16/1982)
    Carcinogenesis Bioassay of Melamine (CAS No. 108-78-1) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: FR: 0,4500,9000, MR&M: 0,2250,4500 PPM/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (951364) Completed 
  • Mice
  • Chromosome Aberation  Positive (Nonstandard Protocol) 
• In Vitro Cytogenetics (CA/SCE)  (828756) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Inconclusive 
• Drosophila  (206373) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive 
• Mouse Lymphoma  (091419) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Negative 
• Micronucleus  (039087) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (986479) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Sister Chromatid Exchanges  (951364) Completed 
  • Mice
  • Sister Chromatid  Positive