Testing Status of Agents at NTP
4,4'-Sulfonyldianiline (Dapsone)
CASRN: 80-08-0
Formula: C12 H12 N2 O2 S
Synonyms/Common Names:
- DAPSONE
- DAPSONE (AIDS)
- 4,4'-SULFONYBISBENZENAMINE (9CI)
Known Uses:
HARDENING AGENT FOR EPOXY RESINS; TOPICAL ANTIBACTERIAL AGENT; TREATMENT OF GYNECOLOGIC NEOPLASMS; ANTIBACTERIAL/ANTIPROTOZOAL IN VET. MEDICINE, USED IN TREATMENT OF LEPROSY
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C01718) Completed
- NTIS No. PB274394
(Peer Review 07/25/1977)
Citation: Bioassay of Dapsone for Possible Carcinogenicity (CAS No. 80-08-0) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB274394
(Peer Review 07/25/1977)
- 13-Week (Dosed-Feed)
(C01718) Completed
- NTIS No. PB274394
(Peer Review 07/25/1977)
Citation: Bioassay of Dapsone for Possible Carcinogenicity (CAS No. 80-08-0) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,1200,30000, M: 0,2000,50000 PPM/5 PER GROUP
- NTIS No. PB274394
(Peer Review 07/25/1977)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C01718) Report Complete
- TR-020 (NTIS No. PB274394)
(Peer Review 07/25/1977)
Bioassay of Dapsone for Possible Carcinogenicity (CAS No. 80-08-0) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0,600,1200, M: 0,500,1000 PPM/35 PER GROUP
- TR-020 (NTIS No. PB274394)
(Peer Review 07/25/1977)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(954704) Completed
- Chromosome Aberation Weakly Positive
- Sister Chromatid Exchange Negative
- In Vitro Cytogenetics (CA/SCE)
(962654) Completed
- Chromosome Aberation Weakly Positive
- Sister Chromatid Exchange Not Tested
- Mouse Lymphoma
(001410) Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Negative
- Salmonella (NCI)
(CV-204) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Negative
- Salmonella
(318705) Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Negative
Organ Systems Toxicity
- Immunotoxicity (Gavage)
(IMM90015) Completed
- NTIS No. PB92-140383
Citation: Summary Reports on Immunotoxicology Vol. 1, No. 1-15 - Citation: SUMMARY (1-15)
- F Mice: C57BL/6
- Dose: 0, 3.4, 13.5, 54.0 MG/KG
- NTIS No. PB92-140383
- 1 TO 31 Repro/Dev Gen Tox (28-Day) (Gavage)
(RACB93157) Completed
- M/F Mice: Swiss
- Dose: N/A; N/A; N/A; N/A
Web page last updated on January 22, 2009